A5055095939- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Adolescent Sexual and Reproductive Health
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- Hepatitis C virus research
- Health Systems, Economic Evaluations, Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Psychology of Moral and Emotional Judgment
- Colorectal Cancer Treatments and Studies
- Reproductive tract infections research
- Emergency and Acute Care Studies
- Statistical Methods and Bayesian Inference
- SARS-CoV-2 and COVID-19 Research
- Misinformation and Its Impacts
- Pharmaceutical studies and practices
Fred Hutch Cancer Center
2020-2025
Imperial College London
2019-2022
Johns Hopkins University
2019-2022
Johns Hopkins Medicine
2022
University of Zambia
2022
London School of Hygiene & Tropical Medicine
2022
Faculty of Public Health
2022
Family Health International 360
2022
Stellenbosch University
2022
National Institute for Health Research
2019
A universal testing and treatment strategy is a potential approach to reduce the incidence of human immunodeficiency virus (HIV) infection, yet previous trial results are inconsistent.
Abstract Introduction HPTN 071 (PopART) implemented a comprehensive HIV prevention package which aimed to reduce incidence within 21 communities of Zambia and South Africa: Arm A, PopART intervention universal testing treatment; B, with ART provided according local guidelines; C, standard care. Analyses so far have not accounted for the sampling design enrolled cohort. We performed sample-weighted re-analysis primary outcome trial derive population-based estimate effect. Methods Enrollment...
During January-August 2021, the Community Prevalence of SARS-CoV-2 Study used time/location sampling to recruit a cross-sectional, population-based cohort estimate seroprevalence and nasal swab sample PCR positivity across 15 US communities. Survey-weighted estimates infection vaccine willingness among participants at each site were compared within demographic groups by using linear regression models with inverse variance weighting. Among 22,284 persons >2 months age older, median prevalence...
Background Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% prevention efficacy against highly neutralization-sensitive viruses but was ineffective less sensitive viruses. VRC07-523LS is next-generation bnAb and engineered increased neutralization breadth half-life. We conducted multicenter, randomized, partially...
Abstract Background Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the only bnAb HIV prevention efficacy studies to date, Antibody Mediated Prevention (AMP) trials, CD4-binding site targeting bnAb, VRC01, administered intravenously (IV), demonstrated 75% against highly neutralization-sensitive viruses but was ineffective less sensitive viruses. Greater is required before passively bnAbs become viable option prevention; furthermore subcutaneous (SC)...
Abstract Background Vaccine hesitancy has been a significant concern throughout the COVID-19 pandemic. can be attributed to lack of confidence in vaccines, complacency about health threat, or convenience vaccination. To date, few studies have used methods designed include populations underrepresented research when identifying factors associated with vaccine hesitancy. Methods Between January and July 2021, potential participants were recruited from community venues selected through...
Universal HIV testing and treatment (UTT) strategies aim to optimize population-level benefits of antiretroviral treatment. Between 2012 2018, four large community randomized trials were conducted in eastern southern Africa. While their results broadly consistent showing decreased viremia reduces incidence, it remains unclear how much incidence can be reduced by increasing suppression among people living with (PLHIV). We a pooled analysis across the UTT trials. Leveraging data from 105...
Universal HIV testing and treatment aims to identify all people living with offer them treatment, decreasing the number of individuals unsuppressed thus reducing transmission. Longitudinal follow-up without in a cluster-randomized trial communities allowed for examination community- individual-level measures risk incidence.
COVID-19 has placed a disproportionate burden on underserved racial and ethnic groups, community members working in essential industries, those living areas of high population density, reliant in-person services such as transportation. The goal this study was to estimate the cross-sectional prevalence SARS-CoV-2 (active or prior infection) children adults attending public venues 15 sociodemographically diverse communities United States develop statistical design that could be rigorously...
BackgroundThe long-term impact of universal home-based testing and treatment as part (UTT) on HIV incidence is unknown. We made projections using a detailed individual-based model the effect intervention delivered in HPTN 071 (PopART) cluster-randomised trial.MethodsIn this modelling study, we fitted an to epidemic care cascade 21 high prevalence communities Zambia South Africa that were PopART trial (intervention period Nov 1, 2013, Dec 31, 2017). The represents coverage counselling by age...
The COVPN 5002 (COMPASS) study aimed to estimate the prevalence of SARS-CoV-2 (active or prior infection) in children and adults attending public venues 15 socio-demographically diverse communities United States. To protect against potential challenges implementing traditional sampling strategies, time-location (TLS) using complex involving stratification, clustering units, unequal probabilities selection was used recruit individuals from neighborhoods selected communities. innovative design...