A5072974600- Virus-based gene therapy research
- Veterinary Oncology Research
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Surgical Sutures and Adhesives
- Corneal Surgery and Treatments
- Biomarkers in Disease Mechanisms
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- COVID-19 Impact on Reproduction
- Gut microbiota and health
- Cancer Cells and Metastasis
- Microbial infections and disease research
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Intraocular Surgery and Lenses
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV-related health complications and treatments
- Nausea and vomiting management
Fundação Oswaldo Cruz
2025
Queen Mary University of London
2019-2024
Barts Health NHS Trust
2022
William Harvey Research Institute
2022
Singapore Institute of Technology
2021
Royal Veterinary College
2017-2020
Immune Regulation (United Kingdom)
2017
Universidade Federal do Rio Grande
2015
University of Rio Grande and Rio Grande Community College
2015
University of Minnesota
2010-2014
Abstract Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms stroma to suppress ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, trial for patients advanced, unresectable PDAC (n = 27), ATRA is re-purposed as stromal-targeting agent combination gemcitabine-nab-paclitaxel chemotherapy using two-step adaptive continual re-assessment method design. The maximum tolerated (MTD) recommended 2...
Background: Severe COVID-19 presents a variety of clinical manifestations associated with inflammatory profiles. People living HIV (PLWH) could face higher risk hospitalization and mortality from COVID-19, depending on their immunosuppression levels. This study describes markers in outcomes without infection. Methods: We analyzed 112 inpatients the Hospital Center for (INI/FIOCRUZ), including 22 cases PLWH (COVID/PLWH group). Plasma samples were tested panel 15 cytokines by Luminex....
Dogs with naturally occurring cancer represent an important large animal model for drug development and testing novel immunotherapies. However, poorly defined immunophenotypes of canine leukocytes have limited the study tumor immunology in dogs. The accumulation myeloid derived suppressor cells (MDSCs) is known to be a key mechanism immune suppression tumor-bearing mice human patients. We sought identify MDSCs blood dogs cancer. Peripheral mononuclear (PBMCs) from advanced or early stage...
Abstract Malignant and atypical meningiomas are resistant to standard therapies associated with poor prognosis. Despite progress in the treatment of other tumors therapeutic vaccines, this approach has not been tested preclinically or clinically these tumors. Spontaneous canine meningioma is a meaningful but underutilized model for preclinical testing novel strategies aggressive human meningioma. We treated 11 meningioma-bearing dogs surgery vaccine immunotherapy consisting autologous tumor...
Abstract Myeloid-derived suppressor cells (MDSCs) are key players in immune evasion, tumor progression and metastasis. MDSCs accumulate under various pathological states fall into two functionally phenotypically distinct subsets that have been identified humans mice: polymorphonuclear (PMN)-MDSCs monocytic (M)-MDSCs. As dogs an excellent model for human development progression, we set out to identify PMN-MDSCs M-MDSCs clinical canine oncology patients. Canine hypodense MHC class II − CD5...
Abstract Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. A multi-center cohort of PDAC patients and controls (chronic pancreatitis, intra-ductal papillary neoplasms, gallstones otherwise healthy) donated serum in an ethically approved manner. Serum PTX3 above 4.34 ng/mL a higher sensitivity (86%, 95% confidence interval (CI): 65–97%) specificity CI:...
Regulatory T cells (Tregs) are a double-edged regulator of the immune system. Aberrations Tregs correlate with pathogenesis inflammatory, autoimmune and neoplastic disorders. Phenotypically functionally distinct subsets have been identified in humans mice on basis their extensive portfolios monoclonal antibodies (mAb) against Treg surface antigens. As an important veterinary species, dogs increasingly recognised as excellent model for many human diseases. However, insightful study canine has...
Abstract Natural Killer (NK) cells have been shown to possess potent anti-tumor activity against multiple cancer types and consequently harnessed as a cellular immunotherapy. Furthermore, targeting of pancreatic stellate has received increasing interest in the treatment ductal adenocarcinoma (PDAC), with several clinical trials testing hypothesis that rendering activated cells/cancer associated fibroblasts (aPSC/CAF) into quiescent state (qPSC) can enhance anticancer treatment. Despite this...
Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver ductal adenocarcinoma (PDAC) chemoresistance leading poor prognosis. Specialized pro-resolving mediators (SPMs) are prime modulators inflammation and its resolution, traditionally thought be produced by immune cells. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based lipid mediator profiling PSCs...
Gene expression profiling has revealed molecular heterogeneity of diffuse large B cell lymphoma (DLBCL) in both humans and dogs. Two DLBCL subtypes based on origin are generally recognized, germinal center (GCB)-like activated (ABC)-like. A pilot study to characterize the transcriptomic phenotype 11 dogs with multicentric BCL yielded two distinguished basis genes important oxidative phosphorylation. We propose a metabolic classification canine that transcends shows parallels similar human...
The aim of this study was to evaluate the cicatricial repair perforating cornea in rabbits, by using N-butyl cyanoacrylate adhesive compared 910-polyglactine thread suture through macroscopic and histological assays. Corneas from 18 adult rabbits were perforated subsequently occluded with synthetic (right cornea) or separated single points (left cornea). divided into groups containing three animals per group. Examination after 7, 15, 30 days post-operative showed that both efficient...
Pancreatic ductal adenocarcinoma (PDAC) remains one of medicine's most urgent areas unmet need. With 5-year survival rates ∼11%, PDAC is set to become the second leading cause cancer related deaths by 2040 [1]. The complex tumour microenvironment (TME) in PDAC, responsible for poor prognosis, comprised extracellular matrix (ECM) proteins and multiple cell types; with pancreatic stellate cells (PSCs), which activated associated fibroblasts (CAFs), being regarded as key orchestrators TME. We...
Background: Severe COVID-19 presents a variety of clinical manifestations associated with inflammatory profiles. People living HIV (PLWH) could face higher risk hospitalization and mortality from COVID-19, depending on their immunosuppression levels. This study describes markers in outcomes without HIV. Methods: We analyzed 112 inpatients the Hospital Center for (INI/FIOCRUZ), including 22 cases PLWH (COVID/PLWH group). Plasma samples were tested panel 15 cytokines by Luminex....
A Revista Brasileira de Cirurgia Plástica é o órgão oficial divulgação da Sociedade (SBCP), tem como objetivo registrar a produção científica em Plástica, fomentar estudo, aperfeiçoamento e atualização dos profissionais especialidade.
a ráfia, sendo ferida da córnea do globo ocular direito com o adesivo sintético N-butil cianoacrilato e esquerdo pontos simples separados fio poliglactina 910.Os animais foram em três grupos de igual número decorridos 7, 15 30 dias pós operatório notou-se que tanto como sutura eficientes na síntese das feridas, estabilizando conteúdo intra-ocular.O mostrouse superior ao 910 quanto à evolução organização processo cicatricial.
Due to the complexity of human tumor environment and host immune interactions, majority successful brain cancer therapies in rodent models fail show same efficacy when translated patients. Pet dogs with spontaneous glioma recapitulate important features disease we have used this more representative model assess response vaccine immunotherapy without interferon gamma (IFN-γ) gene therapy after surgery. Dogs newly diagnosed underwent surgical debulking were randomized receive 1) autologous...
Immunotherapy for malignant gliomas has striking efficacy in rodent models but very limited effects clinical trials, which may reflect immunological differences between induced and spontaneous tumors. The monocytes that heavily infiltrate GBM develop myeloid-derived suppressor cell (MDSC) phenotype, these immunosuppressive cells are increased patients, not murine models. Canine primary brain tumors offer a more faithful representation of the human disease due to similarities pathobiological...