A5023446290- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Endometrial and Cervical Cancer Treatments
- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Radiation Dose and Imaging
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Diverticular Disease and Complications
- Advanced Neuroimaging Techniques and Applications
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Neuroblastoma Research and Treatments
- Radiation Therapy and Dosimetry
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatitis Pathology and Treatment
- Peripheral Nerve Disorders
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Pelvic and Acetabular Injuries
Cambridge University Hospitals NHS Foundation Trust
2021-2024
Addenbrooke's Hospital
2021-2024
Royal Marsden NHS Foundation Trust
2020-2023
Institute of Cancer Research
2020-2023
Creative Commons
2023
Imperial College London
2023
Imperial College Healthcare NHS Trust
2023
University College London
2023
University College Hospital
2023
Guy's and St Thomas' NHS Foundation Trust
2023
Abstract Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms stroma to suppress ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, trial for patients advanced, unresectable PDAC (n = 27), ATRA is re-purposed as stromal-targeting agent combination gemcitabine-nab-paclitaxel chemotherapy using two-step adaptive continual re-assessment method design. The maximum tolerated (MTD) recommended 2...
Abstract Objectives Percutaneous liver biopsy (PLB) poses specific challenges in oncological patients such as bleeding and tumour seeding. This study’s aim was to compare a coaxial (C-PLB) non-coaxial (NC-PLB) technique terms of diagnostic yield, safety seeding risk image-guided PLB techniques an setting. Methods Local research committee approval obtained for this single-site retrospective study. Patients who underwent between November 2011 December 2017 were consecutively included. Medical...
Abstract Purpose: Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare accuracy of 18F-ethyl-choline-(FEC)-PET/CT, 18F-fluoro-deoxy-glucose-(FDG)-PET/CT, diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI. Experimental Design: A prospective, multicenter observational study diagnostic metastases was undertaken 5 gyne-oncology centers. FEC-PET/CT, FDG-PET/CT, DW-MRI were compared size...
Background Correct staging and treatment initiation in malignant lymphoma depends on accurate lymph node characterization. However, nodal assessment based conventional diffusion‐weighted (DWI) MRI remains challenging, particularly smaller nodes. Purpose To evaluate first‐order apparent diffusion coefficient (ADC) texture parameters compared to mean ADC for characterization non‐Hodgkin (NHL) using whole‐body DWI (WB‐DWI). Study Type Retrospective. Population Twenty‐eight patients with NHL....
Background Treatment of female pelvic malignancies often causes nerve damage. Magnetic resonance (MR) neurography mapping the innervation could aid in treatment planning. Purpose To depict autonomic and somatic using a modified 3D NerveVIEW sequence. Material Methods Prospective study 20 volunteers (n = 6 normal, n 14 cervical pathology) who underwent short TI inversion recovery (STIR) turbo spin-echo (TSE) scan with motion-sensitive driven equilibrium (MSDE) preparation radiofrequency pulse...
Abstract Objectives Diffusion-weighted imaging (DWI) with simultaneous multi-slice (SMS) acquisition and advanced processing can accelerate time improve MR image quality. This study evaluated the quality apparent diffusion coefficient (ADC) measurements of free-breathing DWI acquired from patients liver metastases using a prototype SMS-DWI (with/without an option) conventional DWI. Methods Four schemes were compared in pilot 5-patient cohort; three further assessed 24-patient cohort. Two...
The role of hepatic venous pressure gradient (HVPG) measurement in risk stratification before liver resection is an ongoing area debate. This study examines the impact preoperative HVPG levels on overall survival (OS)/time to recurrence (TTR) and postoperative complications after hepatocellular carcinoma (HCC). Thirty-eight HCC patients undergoing at Cambridge University Hospitals NHS Foundation Trust between January 2014 April 2022 were retrospectively analysed. Statistical analysis...
<p>Supplementary data</p>
<div>AbstractPurpose:<p>Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare accuracy of <sup>18</sup>F-ethyl-choline-(FEC)-PET/CT, <sup>18</sup>F-fluoro-deoxy-glucose-(FDG)-PET/CT, diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI.</p>Experimental Design:<p>A prospective, multicenter observational study diagnostic metastases was undertaken...
Objectives Whole-body magnetic resonance imaging (WB-MRI) has been demonstrated to be efficient and cost-effective for cancer staging. The study aim was develop a machine learning (ML) algorithm improve radiologists' sensitivity specificity metastasis detection reduce reading times. Materials Methods A retrospective analysis of 438 prospectively collected WB-MRI scans from multicenter Streamline studies (February 2013–September 2016) undertaken. Disease sites were manually labeled using...
Purpose To evaluate the prognostic utility of apparent diffusion coefficient (ADC) changes at whole-body diffusion-weighted (WB-DW) MRI after one treatment cycle for aggressive non-Hodgkin lymphoma (NHL) compared with response assessment interim and end-of-treatment fluorine 18 (18F) fluorodeoxyglucose (FDG) PET/CT. Materials Methods This was a secondary analysis prospective study (ClinicalTrials.gov identifier: NCT01231269) in which participants NHL were recruited between March 2011 April...