A5008712312- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Viral-associated cancers and disorders
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
King's College London
2016-2023
St Thomas' Hospital
2009-2023
King's College Hospital
2023
Guy's and St Thomas' NHS Foundation Trust
2007-2021
Guy's Hospital
2021
Kings Health Partners
2020
The King's College
2019
University College London
2007-2011
The Royal Free Hospital
2008-2011
British Nuclear Medicine Society
2006-2007
PurposeEarly and accurate localization of lesions in patients with biochemical recurrence (BCR) prostate cancer may guide salvage therapy decisions. The present study, 18F-Fluciclovine PET/CT biochemicAL reCurrence Of Prostate caNcer (FALCON; NCT02578940), aimed to evaluate the effect 18F-fluciclovine on management men BCR cancer.Methods MaterialsMen a first episode after curative-intent primary were enrolled at 6 UK sites. Patients underwent positron emission tomography/computed tomography...
Accurate staging of classical Hodgkin lymphoma (CHL) directs treatment intensity. Functional imaging can detect marrow/bone involvement making the role bone marrow biopsy (BMB) unclear. We assessed current UK practice in CHL by questionnaire and retrospectively analyzed patients staged at a single center with BMB (18)F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). From 34 responses 50% used FDG-PET/CT routinely. was employed 97% advanced-stage 30%...
Abstract Purpose To determine the impact on clinical management of patients with high-risk (HR) prostate cancer at diagnosis and biochemical recurrence (BCR) using a new kit form 68 Ga-prostate-specific membrane antigen (PSMA), namely tris(hydroxypyridinone) (THP)-PSMA, positron emission tomography-computed tomography (PET-CT). Methods One hundred eighteen consecutive (50 HR, BCR) had plans documented multidisciplinary meeting before Ga-THP-PSMA PET-CT. Patients underwent PET-CT scans 60-min...
Summary Standard treatment for classical Hodgkin lymphoma (cHL) is poorly tolerated in older patients and results disappointing. We assessed safety efficacy of brentuximab vedotin (BV), previously untreated with cHL unfit standard due to age, frailty or comorbidity. The primary outcome was complete metabolic response (CMR) by positron emission tomography/computed tomography after four BV cycles (PET4). secondary outcomes included progression‐free survival (PFS), overall (OS), toxicity. In...
O1 Tumour heterogeneity: what does it mean? Dow-Mu Koh O2 Skeletal sequelae in adult survivors of childhood cancer Sue Creviston Kaste O3 Locoregional effects breast treatment Sarah J Vinnicombe O4 Imaging therapy-induced CNS toxicity Giovanni Morana, Andrea Rossi O5 Screening for lung Christian J. Herold O6Risk stratification nodules Theresa C. McLoud O7 PET imaging pulmonary Kirk A Frey O8 Transarterial tumour therapy Bernhard Gebauer O9 Interventional radiology paediatric oncology Derek...
Abstract Purpose: Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare accuracy of 18F-ethyl-choline-(FEC)-PET/CT, 18F-fluoro-deoxy-glucose-(FDG)-PET/CT, diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI. Experimental Design: A prospective, multicenter observational study diagnostic metastases was undertaken 5 gyne-oncology centers. FEC-PET/CT, FDG-PET/CT, DW-MRI were compared size...
Interim PET scans in HIV-negative patients with Hodgkin lymphoma has emerged as one of the most important prognostic tools. However, equivalent studies HIV-positive are yet to be performed.We evaluated value interim [18F]-fluoro-2-deoxy-D-glucose-PET (18F-FDG PET) after two or three cycles chemotherapy using adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) concomitant HAART lymphoma.Patients advanced HIV-Hodgkin (HIV-HL) from six UK centres were included. ABVD (PET-2 PET-3) carried...
Measurement of heterogeneity in
Abstract Patients with relapsed or refractory diffuse large B‐cell lymphoma (DLBCL) who are unfit for postautologous stem‐cell transplantation have poor outcomes. Historically, mTORC1 inhibitors produced responses in approximately 30% of patients this setting. inhibitor efficacy may be limited by resistance mechanisms including AKT activation mTORC2. To date, dual mTORC1/2 targeting both the TORC1 and TORC2 complexes not been investigated DLBCL. This phase II trial oral vistusertib an...
Our objectives were to assess the safety and clinical impact of a novel, kit-based formulation <sup>68</sup>Ga-tris(hydroxypyridinone) (<sup>68</sup>Ga-THP) prostate-specific membrane antigen (PSMA) for PET/CT in guiding management patients with prostate cancer. <b>Methods:</b> Patients prospectively recruited group A (high-risk untreated cancer; Gleason score ≥ 4 + 3, or (PSA) level > 20 ng/mL stage T2c), B (biochemical recurrence eligible salvage treatment after radical prostatectomy 2...
Aim qPET is a quantitative method used to assess FDG-PET response in lymphoma. was developed using 898 scans from children with Hodgkin Lymphoma (HL) the EuroNet-PHL-C1 (C1) trial. The aim of this study determine if could be applied as an alternative adults RAPID Methods PET-CT performed after 3 cycles ABVD were re-evaluated by independent reader, blinded PET results and outcome RAPID. All initially involved regions assessed visually qPET. distribution measurements compared for C1 patients....
Primary hepatic lymphoma is a rare presentation of common disease. Diagnosis difficult due to the risks liver biopsy. We report clinico-pathologic features this and specifically utility image-guided biopsy as safe method diagnosis. retrospectively studied patients diagnosed with ‘hepatic lymphoma’ at single center. Twenty-two fulfilled criteria. Median age was 53 years (range 29–87). Nine were human immunodeficiency virus (HIV)-positive. The most frequent mode B-symptoms (15/22). All...
Interim PET (iPET) assessment is important for response adaptation in Hodgkin lymphoma (HL). The current standard iPET the Deauville score (DS). aim of our study was to evaluate causes interobserver variability assigning DS HL patients and make suggestions improvement.All evaluable scans from RAPID were re-read by two nuclear physicians, blinded results patient outcomes trial. assessed visually according and, thereafter, quantified using qPET method. All discrepancies more than one level...
Texture features are being increasingly evaluated in 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as adjunctive imaging biomarkers a number of different cancers. Whilst studies have reported repeatability between scans, there been no that specifically investigated the effect time acquisition post-injection 18F-FDG has on texture features. The aim this study was to investigate if change scans performed at points post-injection. Fifty-four patients (30 male, 24 female,...
In-pentetreotide scan (OctreoScan) is a widely available agent with high sensitivity for imaging neuroendocrine tumours. Negative poses diagnostic as well therapeutic problems in terms of staging and consideration targeted radionuclide therapy.To assess the role Tc-depreotide patients negative or weakly positive OctreoScan (Krenning score< =1; measured on scale range 0-4). To determine usefulness scintigraphy highlighting lesions that may be missed by and/or CT/MRI imaging.Prospective...
Introduction: Standard treatment for Hodgkin lymphoma (HL) is poorly tolerated in older patients and results are disappointing. Brentuximab vedotin (BV) a CD30 targeted antibody-drug conjugate licenced the of relapsed or refractory HL on basis excellent safety efficacy demonstrated pivotal phase 2 clinical trial. BREVITY trial was designed to evaluate tolerability BV monotherapy previously untreated (pts) with unfit standard due age, frailty co-morbidity. Methods: This response adaptive II,...
Primary vulvar carcinoma is rare and thought to arise from either anogenital mammary-like glands or native apocrine sweat glands. The diagnosis predominantly based on tumor morphology with supportive evidence immunohistochemical staining exclusion of a primary breast carcinoma. modality treatment surgery, while optimal managment advanced disease unclear. We present the case lady who had metastatic recurrent expressing estrogen receptors, complete response assessed by PET-CT scanning after 7...
The purpose of these guidelines is to assist specialists in Nuclear Medicine and Radionuclide Radiology recommending, performing, interpreting reporting 18F-fluciclovine PET/computed tomography. It should be recognised that adherence the guidance this document will not assure an accurate diagnosis or a successful outcome. These individual departments formulation their own local protocols. apply studies on adults. All expected practitioner follow reasonable course action based current...
Introduction: Most patients (pts) with follicular lymphoma (FL) present advanced disease and are generally considered incurable. For the minority localised disease, radiotherapy (RT) can be curative, historical series showing a 10 year free survival of 40%-50%. PET-CT 18F-flurorodeoxyglucose is gold standard imaging technique for staging FL. Compared to CT, upstaging occurs in 10-60% pts. We evaluated outcomes pts who underwent definitive RT stage I-II FL after by PET-CT. Our hypothesis was...