A5059178090- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- COVID-19 Impact on Reproduction
- Inflammasome and immune disorders
- T-cell and Retrovirus Studies
- Respiratory Support and Mechanisms
- Tannin, Tannase and Anticancer Activities
- Global Maternal and Child Health
- Agricultural and Food Sciences
- HIV-related health complications and treatments
- Maternal and Neonatal Healthcare
- Immune Cell Function and Interaction
- Enterobacteriaceae and Cronobacter Research
- Kawasaki Disease and Coronary Complications
Fundação Oswaldo Cruz
2012-2025
Background: Severe COVID-19 presents a variety of clinical manifestations associated with inflammatory profiles. People living HIV (PLWH) could face higher risk hospitalization and mortality from COVID-19, depending on their immunosuppression levels. This study describes markers in outcomes without infection. Methods: We analyzed 112 inpatients the Hospital Center for (INI/FIOCRUZ), including 22 cases PLWH (COVID/PLWH group). Plasma samples were tested panel 15 cytokines by Luminex....
The SARS-CoV-2 spike protein interacts with ACE2, a key receptor within the renin-angiotensin-aldosterone system (RAAS), which plays critical role in maintaining vascular homeostasis, regulating blood pressure, and modulating inflammation. An observational study analyzed gene expression profiles of RAAS receptors associated miRNAs 88 hospitalized COVID-19 patients 20 healthy controls, comparing acute post-acute phases to assess their impact on disease severity recovery. Our findings revealed...
COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe and death. The mechanisms underlying its evolution are still unclear. Upon SARS-CoV-2 infection, host factors, such as the inflammasome system, activated by presence virus inside cells. search for risk factors is relevance management. In this study, we investigated impact single-nucleotide polymorphisms (SNPs) in SARS-CoV-2-infected individuals with distinct severity profiles at...
COVID-19 has a broad spectrum of clinical manifestations. We assessed the impact single nucleotide polymorphisms (SNPs) inflammasome genes as risk factors for progression to critical outcomes, such mechanical ventilation support (MVS) or death. The study included 451 hospitalized individuals followed up at INI/FIOCRUZ, Rio de Janeiro, Brazil, from 06/2020 03/2021. SNPs genotyping was determined by Real-Time PCR. analyzed MVS (n = 174[38.6 %]) death 175[38.8 result Cox proportional hazard...
Various HIV-1 env genetic and biochemical features impact the elicitation of cross-reactive neutralizing antibodies in natural infections. Thus, we aimed to investigate cross-neutralizing individuals infected with subtypes B, F1, C or B/Bbr variant as well characteristics. Therefore, plasma samples from Brazilian chronically were submitted TZM-bl neutralization assay. We also analyzed putative N-glycosylation sites (PNGLs) size gp120 variable domains context prevalent Brazil. observed a...
The yellow fever (YF) vaccine is one of the safest and most effective vaccines currently available. Still, its administration in people living with HIV (PLWH) limited due to safety concerns a lack consensus regarding decreased immunogenicity long-lasting protection for this population. mechanisms associated impaired YF PLWH are not fully understood, but general immune deregulation during infection may play an important role. To assess if impacts markers could predict lower immunogenicity, we...
Background: Severe COVID-19 presents a variety of clinical manifestations associated with inflammatory profiles. People living HIV (PLWH) could face higher risk hospitalization and mortality from COVID-19, depending on their immunosuppression levels. This study describes markers in outcomes without HIV. Methods: We analyzed 112 inpatients the Hospital Center for (INI/FIOCRUZ), including 22 cases PLWH (COVID/PLWH group). Plasma samples were tested panel 15 cytokines by Luminex....
Between 2016 and 2018, Brazil faced a yellow fever (YF) outbreak, which led to an expansion of vaccination coverage. The coexistence the YF outbreak HIV-1 epidemic in raised concerns regarding immune response vaccine effectiveness individuals living with HIV (PLWH). aim this study was investigate PLWH HIV-uninfected as controls. Transcript levels immunomodulatory molecules, including IL-6, IL-10, IL-21, TGF-β, CD19, CD163, miR-21, miR-146, miR-155, were measured using RTqPCR. TCD4+ cells...
Tests for the detection of humoral immune response to HIV-1 have be standardized and established, demanding regional efforts. For this purpose neutralizing antibody (NAb) assay in TZM-bl cells was introduced Brazil. Twenty plasma samples from HIV-1-infected individuals were assayed: 10 progressors long-term nonprogressors. These tested against eight env-pseudotyped viruses (psVs) NAb strain HTLV/IIIB (HIV-1 IIIB) primary lymphocytes. Forty-four percent showed titers psVs 55% IIIB. Plasma a...
Background and objectives: For decades, dengue outbreaks have been affecting vast territories of the Americas. In 2010’s decade, Chikungunya Zika virus (CHIKV ZIKV) emerged as new arboviruses in region. While several seroprevalence rates reported for (DENV) infection Brazil, serological surveys latest are scarce. We aimed to evaluate CHIKV, ZIKV, DENV infections pregnant women at admission a public maternity hospital Nova Iguaçu, state Rio de Janeiro. Methods: A simple questionnaire was...
Abstract COVID-19 has challenged the scientific community in search for biological markers and information that can contribute to early management of severe disease. Given global scale COVID-19, including reports reinfection even presence effective vaccines, we have not yet been able eradicate This factor implies emergence new waves an increasing number hospitalizations. study aimed characterize neutralizing antibody (Nab) geometric mean titers (GMTs) hospitalized patients with evaluate...
ABSTRACT COVID-19 has challenged the scientific community in search for biological markers and information that can contribute to early management of severe disease. Given global scale COVID-19, including reports reinfection even presence effective vaccines; consequently, eradication SARS-CoV-2 is far from happening. This study aimed characterize neutralizing antibody (Nab) geometric mean titers (GMTs) hospitalized patients with evaluate association length stay, comorbidities, patient...
Abstract Background COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic to mild or moderate symptoms, reaching the most severe forms and death. The mechanisms underlying SARS-CoV-2 infection its evolution are still unclear. Once infects individuals, host factors activated by presence virus inside cells, such as inflammasome system. search risk for is relevance management. In this study, we investigated impact 11 single-base polymorphisms (SNPs) in NLRP3, CARD8, AIM2,...