A5102943241- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Global Maternal and Child Health
- Cancer Immunotherapy and Biomarkers
- Sparse and Compressive Sensing Techniques
- Ovarian function and disorders
- Blind Source Separation Techniques
- Birth, Development, and Health
- Maternal and fetal healthcare
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Reproductive System and Pregnancy
- Hypothalamic control of reproductive hormones
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Pelvic floor disorders treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Sperm and Testicular Function
Sichuan Agricultural University
2021-2025
Institute of Molecular and Cell Biology
2023-2024
Agency for Science, Technology and Research
2022-2024
Hubei University of Medicine
2018-2023
XinHua Hospital
2014-2023
Singapore General Hospital
2023
Duke-NUS Medical School
2023
Shanghai Jiao Tong University
2014-2023
Ministry of Agriculture and Rural Affairs
2023
A*STAR Graduate Academy
2022
Background The caesarean section (CS) rate continues to increase across high-income, middle-income and low-income countries. We present current global regional CS rates, trends since 1990 projections for 2030. Methods obtained nationally representative data on the from countries worldwide 2018. used routine health information systems reports population-based household surveys. Using latest available data, we calculated subregional weighted averages. estimated by a piecewise analysis of rates...
Over the past three decades, World Health Organization expert panel proposed cesarean delivery rate of 10-15 percent was used as a doctrine for an optimal despite lack concrete evidence. We set out to compile rates, socioeconomic indicators, and health outcomes by countries in last decades explore rates medically necessary delivery.We selected 19 which have readily accessible low maternal infant mortality, including North West Europe, America, Australia, New Zealand, Japan. Information on...
No consensus definition of macrosomia currently exists among researchers and obstetricians. We aimed to identify a that is more predictive maternal perinatal mortality morbidity in low- middle-income countries. conducted secondary data analysis using WHO Global Survey on Maternal Perinatal Health Africa Latin America from 2004 2005 Asia 2007 2008. compared adverse outcomes, which were assessed by the composite index (MMMI) (PMMI) subgroups with birthweight (3000–3499 g [reference group],...
The motility of sperm decreases following cryopreservation, which is closely associated with mitochondrial function. However, the alterations in metabolism after freezing goats remain unclear. This experiment aimed to investigate impact ultra-low temperature on goat sperm's energy and its potential correlation motility. results revealed that exhibited vacuolization, reduced matrix density, significantly decreased levels high-membrane mitochondria adenosine triphosphate content, accompanied...
Background Macrosomia has been defined in various ways by obstetricians and researchers. The purpose of the present study was to search for a definition macrosomia through an outcome-based approach. Methods In 30,831,694 singleton term live births 38,053 stillbirths U.S. Linked Birth-Infant Death Cohort datasets (1995–2004), we compared occurrence stillbirth, neonatal death, 5-min Apgar score less than four subgroups birthweight (4000–4099 g, 4100–4199 4200–4299 4300–4399 4400–4499 4500–4999...
Objectives Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of women at reproductive age. Although aetiology PCOS remains unclear, potential effects environmental endocrine-disrupting compounds on development have drawn increasing attention. The aim current study was to examine association between triclosan (TCS) and PCOS, explore possible mechanisms how TCS may contribute clinical manifestations PCOS. Design Cross-sectional study. Setting This conducted in one...
A successful pregnancy requires the maternal immune system to accept a fetus expressing allogeneic paternal antigens and provide competent responses infections. Accordingly, maternal‑fetal abnormalities may have an important role in development of recurrent spontaneous abortion (RSA). Ever since establishment association between immunologic RSA, various types therapy restore normal homeostasis been increasingly developed. Although previous studies focused on interface, non‑invasive...
This study investigated the effects of high‑dose long‑term antioxidant free radicals on mortality rate, creatinine (Cr) value, partial pressure oxygen (PaO2), alanine aminotransferase (ALT), as well incidence rates lung fibrosis and dysfunction in treatment patients with severe paraquat (PQ) poisoning [toxic dose, 20 ml stock solution (20% w/v)]. A total 23 cases PQ treated Xiangyang First People's Hospital, Hubei University Medicine were collected (group 1), they received conventional...
During normal pregnancy, delicate crosstalk is established between fetus-derived trophoblasts and maternal immune cells to ensure maternal-fetal tolerance successful placentation. Dysfunction in these interactions has been highly linked certain pregnancy complications.Naïve CD4+ T were cultivated with or without 1st trimester derived trophoblast cell line HTR8/SVneo the absence presence of helper 17 (Th17) regulatory (Treg)cell-inducing differentiation conditions. After 5 days co-culture,...
Combination therapy with radioembolization (yttrium-90)-resin microspheres) followed by nivolumab has shown a promising response rate of 30.6% in Phase II trial (CA209-678) for advanced hepatocellular carcinoma (HCC); however, the mechanisms and relevant biomarkers remain unknown. By collecting both pretreatment on-treatment samples, we performed multimodal profiling tissue blood samples investigated molecular changes associated favorable responses 33 patients from trial. We found that...
Abstract Natural Killer (NK) cells have been shown to possess potent anti-tumor activity against multiple cancer types and consequently harnessed as a cellular immunotherapy. Furthermore, targeting of pancreatic stellate has received increasing interest in the treatment ductal adenocarcinoma (PDAC), with several clinical trials testing hypothesis that rendering activated cells/cancer associated fibroblasts (aPSC/CAF) into quiescent state (qPSC) can enhance anticancer treatment. Despite this...
Muscle growth and injury-induced regeneration are controlled by skeletal muscle satellite cells (MuSCs) through myogenesis in postnatal animals. Meanwhile, is accompanied mitochondrial function enzyme activity. Nevertheless, the underlying molecular mechanisms involving non-coding RNAs including circular (circRNAs) microRNAs (miRNAs) remain largely unsolved. Here, we explored myogenic roles of miR-145-3p MYBL1 on development mass. We noticed that overexpression inhibited MuSCs proliferation...
The use of labor neuraxial analgesia (NA) in China has increased significantly the past decade, and current rate is unknown. This study aimed to describe epidemiology NA based on a large multicenter cross-sectional survey, Labor Delivery Survey (CLDS) (2015-2016), evaluate association between intrapartum caesarean delivery (CD) maternal neonatal outcomes.The CLDS was facility-based investigation with cluster random sampling scheme conducted from 2015 2016. A specific weight assigned each...