A5018312020- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Carbohydrate Chemistry and Synthesis
- Stroke Rehabilitation and Recovery
- Balance, Gait, and Falls Prevention
- Glycosylation and Glycoproteins Research
- Spinal Cord Injury Research
- Neuroscience and Neural Engineering
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Sport Psychology and Performance
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Enzyme function and inhibition
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and biosynthesis
- Mechanics and Biomechanics Studies
- Biomedical Text Mining and Ontologies
- Chemical Reactions and Mechanisms
- DNA and Nucleic Acid Chemistry
The University of Tokyo
2009-2024
University of Miami
2023-2024
Osaka University
2016-2024
Tokyo University of the Arts
2019-2024
Tokyo University of Agriculture and Technology
2008-2024
Tokyo University of Technology
2024
Japan Society for the Promotion of Science
2019-2023
Tokyo Yamate Medical Center
2019
National Center for Geriatrics and Gerontology
2017
Japan Science and Technology Agency
2009
Might DNA sequence variation reflect germline genetic activity and underlying chromatin structure? We investigated this question using medaka (Japanese killifish, Oryzias latipes ), by comparing the genomic sequences of two strains (Hd-rR HNI) mapping ∼37.3 million nucleosome cores from Hd-rR blastulae 11,654 representative transcription start sites six embryonic stages. observed a distinctive ∼200–base pair (bp) periodic pattern downstream sites; rate insertions deletions longer than 1 bp...
Transcutaneous and epidural electrical spinal cord stimulation techniques are becoming more valuable as electrophysiological clinical tools. Recently, remarkable recovery of the upper limb sensorimotor function during cervical was demonstrated. In present study, we sought to elucidate neural mechanisms underlying effects transcutaneous (tSCS) spine. We hypothesized that tSCS can be used selectively activate sensory route entering transsynaptically converge on motor pools. To test this...
Cervical transcutaneous spinal cord stimulation (tSCS) efficacy for rehabilitation of upper-limb motor function was suggested to depend on recruitment Ia afferents. However, selectivity and excitability activation with different electrode configurations remain unclear. In this study, pools examined cathode anode during cervical tSCS in 10 able-bodied individuals. Muscle responses were measured from six muscles simultaneously. First, postactivation depression confirmed paired pulses (50-ms...
Memory CD4(+) T cells are central regulators of both humoral and cellular immune responses. cell differentiation results in specific changes chromatin structure DNA methylation cytokine genes. Although the status a limited number gene loci has been examined, genome-wide memory remains unexplored. To further elucidate molecular signature cells, we conducted methylome transcriptome analyses generated using from TCR-transgenic mice. The resulting profile revealed 1144 differentially methylated...
Manipulations require complex upper limb movements in which the central nervous system (CNS) must deal with many degrees of freedom. Evidence suggests that CNS utilizes motor primitives called muscle synergies to simplify production movements. However, exact neural mechanism underlying control a wide array manipulations is not fully understood. Here, we tested whether there are basic units can explain diverse range manipulations. We measured electromyographic activities 20 muscles across...
Abstract Background Neuromuscular electrical stimulation (NMES) can generate muscle contractions and elicit excitability of neural circuits. However, the optimal frequency for effective neuromodulation remains unclear. Methods Eleven able‐bodied individuals participated in our study to examine effects of: (1) low‐frequency NMES at 25 Hz, (2) high‐frequency 100 Hz; (3) mixed‐frequency Hz switched every second. was delivered right tibialis anterior (TA) 1 min each condition. The order...
Massively parallel, tag-based sequencing systems, such as the SOLiD system, hold promise of revolutionizing study whole genome gene expression due to number data points that can be generated in a simple and cost-effective manner. We describe development 5'-end transcriptome workflow for system demonstrate advantages sensitivity dynamic range offered by this application over traditional approaches expression. analysis was used within colon cancer cell line, HT-29, treated with DNA...
Despite their disabilities, top Paralympic athletes have better motor skills than able-bodied athletes. However, the neural underpinnings of these remain unclear. We investigated reorganization primary cortex (M1) in a athlete with congenital amputation both arms who holds world record for farthest accurate shot archery (Amputee Archer: AA). recorded brain activity during contraction right toe, ankle, knee, and hip joint muscles AA 12 control subjects using functional magnetic resonance...
The extent to which muscle synergies represent the neural control of human behavior remains unknown. Here, we tested whether certain sets that are fundamentally necessary across behaviors exist. We measured electromyographic activities 26 muscles, including bilateral trunk and lower limb during 24 locomotion, dynamic static stability tasks, extracted using non-negative matrix factorization. Our results show 13 may have unique functional roles accounted for almost all tasks by combinations...
Abstract It is well known that contracting the upper limbs can affect spinal reflexes of lower limb muscle, via intraneuronal networks within central nervous system. However, it remains unknown whether neuromuscular electrical stimulation (NMES), which generate muscle contractions without commands from cortex, also play a role in such inter-limb facilitation. Therefore, objective this study was to compare effects unilateral using NMES and voluntary on reflex facilitation muscles. Spinal...
Functional electrical stimulation therapy (FEST) can improve motor function after neurological injuries. However, little is known about cortical changes FEST and weather it traumatic brain injury (TBI). Our study examined improvements in one male participant with chronic TBI suffering from mild impairment affecting the right upper-limb during 3-months of follow-up. In total, 36 sessions were applied to enable grasping reaching movements. Short-term assessments carried out using transcranial...
Muscle synergy analysis is useful for investigating trunk coordination patterns based on the assumption that central nervous system reduces dimensionality of muscle activation to simplify movement. This study aimed quantify variability in during various motor tasks healthy participants provide reference data evaluating control strategies patients and athletes. Sixteen individuals performed 11 movement stability with electromyography (EMG) recording their spinal abdominal muscles (6...
MachiBase (http://machibase.gi.k.u-tokyo.ac.jp/) provides a comprehensive and freely accessible resource regarding Drosophila melanogaster 5′-end mRNA transcription at different developmental states, supporting studies on the variabilities of promoter transcriptional activities gene-expression profiles in fruitfly. The data were generated conjunction with recently developed high-throughput genome sequencer Illumina/Solexa using newly collection method.
Abstract Background Chronic low back pain (CLBP) is a highly prevalent disease with poorly understood underlying mechanisms. In particular, altered trunk muscle coordination in response to specific tasks remains largely unknown. Methods We investigated the synergies during 11 movement and stability 15 healthy individuals (8 females 7 males, aged 21. 3 (20.1–22.8) ± 0.6 years) CLBP participants 20. 9 (20.2–22.6) 0.7 by recording surface electromyographic activities of 12 abdominal muscles...
Background Identifying altered trunk control is critical for treating extension-related low back pain (ERLBP), a common subgroup classified by clinical manifestations. The changed coordination of muscles within this group during particular tasks still not clearly understood. Objectives objective study to investigate muscle 11 movement and stability in individuals with ERLBP compared non-low (LBP) participants. Methods Thirteen non-LBP performed tasks. We recorded the electromyographic...
Emotion affects postural control during quiet standing. Emotional states can be defined as two-dimensional models comprising valence (pleasant/unpleasant) and arousal (aroused/calm). Most previous studies have investigated the effects of on without considering arousal. In addition, focused center pressure (COP) trajectory to examine emotional standing control; however, relationship between neuromuscular mechanisms emotionally affected is largely unknown. This study aimed investigate COP...
We modified the surface of liposomes with galactosyl ligands. At first we determined whether or not moiety was exposed on liposomes. then investigated effect ligands hepatic accumulation in rats. introduced an oligoethylene glycol as a spacer. Among various tested, those tri- tetraethylene spacer caused greatest liver. Liposomes bearing spacer, were aggregated by Ricinus communis agglutinin. On other hand, mono- diethylene did clearly agglutinate. These results show importance between homing...
Cervical transcutaneous spinal cord stimulation (tSCS) has been utilized in applications for improving upper-limb sensory and motor function patients with injury. Although therapeutic effects of continuous cervical tSCS interventions have reported, neurophysiological mechanisms remain largely unexplored. Specifically, it is not clear whether sub-threshold intensity 10-min duration intervention can affect the central nervous system excitability. Therefore, purpose this study was to...