A5101646455- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Influenza Virus Research Studies
- Respiratory viral infections research
- Bone health and osteoporosis research
- Dementia and Cognitive Impairment Research
- Metabolomics and Mass Spectrometry Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Ocular Diseases and Behçet’s Syndrome
- Natural Antidiabetic Agents Studies
- Global Health Care Issues
- Atrial Fibrillation Management and Outcomes
- Ferroptosis and cancer prognosis
- Bone Metabolism and Diseases
- Diet and metabolism studies
- Retirement, Disability, and Employment
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Bioinformatics and Genomic Networks
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
- Synthesis and pharmacology of benzodiazepine derivatives
- Lipoproteins and Cardiovascular Health
- Acupuncture Treatment Research Studies
People's Hospital of Bishan District
2025
First Hospital of Jiaxing
2023-2025
Jiaxing University
2022-2025
Guiyang Medical University
2023-2024
Westlake University
2023-2024
Nanjing Medical University
2014-2021
Wake Forest University
2019
Forest Institute
2019
Charlottesville Medical Research
2019
John Wiley & Sons (United States)
2019
The prevalence of obesity is increasing rapidly worldwide, particularly in Asia. Visceral obesity, characterized by intra-abdominal fat accumulation, a precursor to metabolic syndrome, encompassing hyperglycemia, dyslipidemia, and hypertension, which elevate the risk atherosclerosis cardiovascular disease. A visceral area (VFA) ≥100 cm2 recognized threshold for diagnosing obesity-related syndrome. This study aimed identify independent factors VFA middle-aged Chinese individuals from general...
This study aims to evaluate and compare the clinical differences in intravenous thrombolytic therapy among patients with cerebral infarction transported hospital by private cars versus ambulances Jiaxing, a non-supersized city China. It also sought examine impact of different transportation methods on emergency department arrival times, delays initiating final prognosis. The findings aim provide basis for optimising treatment protocols improving outcomes infarction. Data age, gender, height,...
With gradual progress in the medical field and rising living standard of people, life expectancy people is gradually increasing. Unfortunately, this positive development contributes significantly to aging societies creates huge challenges for pension systems. In order mitigate pressure on its system coming years, China considering increasing retirement age, just like many other countries. Based wage data urban employees, revenue expenditure employees Anhui Province over we constructed a...
ABSTRACT Aims This study aimed to investigate the efficacy of early intensive statin therapy following intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS). Methods AIS who received IVT and were included from multicenter registry databases. The primary endpoint was functional independence, defined by a modified Rankin Scale (mRS) score 0–2 at 90 days. Propensity matching (PSM) analyses employed. Results A total 21,349 this study, mean age 68.5 ± 12.6 years, whom 13,578...
Numerous studies have investigated the alterations of genes, proteins, and metabolites in Behcet's disease (BD). By far, little is known about depiction panoramic changes underlying this disease. This study purposed to assess consistently dysregulated BD across publications using vote-counting approach. was based on 745 that identified a collection 2354 differential molecules with 3574 molecule entries blood, peripheral blood mononuclear cells, CD4+T aqueous humor samples from patients BD....
Macrophage death in advanced atherosclerosis promotes plaque necrosis and destabilization. Involvement of autophagy bulk degradation cellular components has been recognized recently as an important mechanism for cell survival under endoplasmic reticulum (ER) stress. We previously found that the engagement class A scavenger receptor (SR-A) triggered JNK-dependent apoptosis ER-stressed macrophages. However, pro-apoptotic mechanisms mediated by SR-A are not fully understood. Therefore, we...
Hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) in acute ischemic stroke seriously affects the prognosis of patients. This study aimed to investigate risk factors different types HT and their correlation with IVT.Based on CASE II registry, we included patients who received IVT within 4.5 h onset. was further divided into hemorrhagic infarction (HI) parenchymal hemorrhage (PH). Poor outcome defined as a modified Rankin Scale (mRS) score 3-6 at 3 months. Multivariate...
Objective. Intravenous thrombolysis (IVT) is currently the main effective treatment for patients with ischemic stroke. This study aimed to analyze factors affecting early neurological recovery and prognosis of thrombolytic therapy after surgery construct predictive models. Materials Methods. A total 849 stroke who received IVT at six centers from June 2017 March 2021 were included. Patients divided into training cohort validation cohort. Based on independent that influence function...
Abstract Accumulated evidence showed that thyroid diseases induced cognitive decline. However, the relationship between hormones (THs) and cognition in older euthyroid people is still unclear. Our study aimed to estimate association THs within range community-dwelling adults China. Data were extracted from a cohort on health status of rural Guizhou province China (HSRO). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT 4 ), triiodothyronine 3 ) measured using...
Exosomes are critical mediators of intercellular communication in the tumor microenvironment. Exosomal circular RNAs (circRNAs) can act as biomarkers and play crucial roles many cancers, including non-small cell lung cancer (NSCLC). The aim this study was to explore functions regulatory mechanism exosomal circ_0007385 NSCLC. expression levels circ_0007385, microRNA-1253 (miR-1253), family with sequence similarity 83, member A (FAM83A) mRNA were determined by quantitative real-time PCR...
Abstract Background While evidence supports cognitive reserve (CR) in preserving function, longitudinal validation of CR proxies, including later-life factors, remains scarce. This study aims to validate CR’s stability over time and its relation function rural Chinese older adults. Methods Within the project on health status adults (HSRO), survey included baseline assessment (2019) follow-up (2022). 792 (mean age: 70.23 years) were followed up. The confirmatory factor analysis (CFA) was...
Background Studies have shown the positive impact of perceived social support on cognitive function among older adults in rural areas. However, existing studies often overlook different sources. This study aimed to explore relationship between diverse sources and function. Methods Participants were drawn from Guizhou Rural Older Adults’ Health Study (HSRO) China. We included 791 participants who participated a baseline survey 2019 3-year follow-up survey. Perceived was investigated six main...
Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide. The purpose this study to investigate whether Wld(S) (slow Wallerian degeneration; also known as Wld) gene plays a renoprotective role during progression DN. Diabetes was induced in 8-wk-old male wild-type (WT) and C57BL/Wld(S) mice by streptozotocin (STZ) injection. Blood urinary variables including blood glucose, glycated hemoglobin (GHb), insulin, urea nitrogen, albumin/creatinine ratio were assessed 4,...
This study aimed to investigate the association between atrial fibrillation (AF), particularly newly diagnosed AF, and remote intracerebral hemorrhage (rICH) in patients with ischemic stroke who were treated intravenous thrombolysis (IVT). observational was conducted on received IVT recombinant tissue-type plasminogen activator. The data taken from a multicenter prospective registry of Chinese population. rICH defined as any extraischemic detected computerized tomography (CT) 24 h after...
The concept of cognitive reserve (CR) plays a crucial role in understanding aging and resilience. Accumulating evidence revealed the influence CR proxy on function, but it remains unknown whether reverse association or reciprocal effect exists.
Hepatocellular Carcinoma (HCC) is a serious primary solid tumor that prevalent worldwide. Due to its high mortality rate, it crucial explore both early diagnosis and advanced treatment for HCC. In recent years, multi-omic approaches have emerged as promising tools identify biomarkers investigate molecular mechanisms of biological processes diseases. this study, we performed proteomics, phosphoproteomics, metabolomics, lipidomics reveal the features early- advanced-stage The data obtained...
Background: Edaravone dexborneol has been confirmed as a novel neuroprotective agent by acting on multiple active targets of antioxidation and anti-inflammation. Objectives: This study aims to evaluate the effectiveness safety edaravone in patients with acute ischemic stroke (AIS) within 14 days symptom onset real-world clinical practice. Methods: prospective, multicenter, 2-arm, parallel, cohort will involve 72 centers China plans recruit 4750 exposed/unexposed 2:1 ratio gather additional...