A5068191549- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Circular RNAs in diseases
- Medical Imaging Techniques and Applications
- Nutrition, Genetics, and Disease
- Histone Deacetylase Inhibitors Research
- Medical Imaging and Pathology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vanadium and Halogenation Chemistry
- Nutritional Studies and Diet
- Spaceflight effects on biology
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- Microfluidic and Bio-sensing Technologies
- Renal and related cancers
- Urologic and reproductive health conditions
- 3D Printing in Biomedical Research
- Chromatin Remodeling and Cancer
- Consumer Attitudes and Food Labeling
Instituto Português de Oncologia Francisco Gentil
2022-2025
IPO Porto
2022-2025
Universidade do Porto
2023-2025
Research Network (United States)
2023
University of Coimbra
2020-2022
Abstract External beam radiotherapy (RT) is a leading first-line therapy for prostate cancer (PCa), and, in recent years, significant advances have been accomplished. However, RT resistance can arise and result long-term recurrence or disease progression the worst-case scenario. Thus, making crucial discovery of new targets PCa radiosensitization. Herein, we generated radioresistant cell line, found p53 to be highly expressed cells, as well patients with recurrent/disease submitted RT....
Abstract Somatic‐type malignancies (SMs) arising in germ cell tumors (GCTs) are aggressive neoplasms resistant to systemic treatment. Most diagnosed metastatic sites after chemotherapy; however, they have also been well‐documented primary testicular GCTs. Historically, SMs were thought originate components of teratoma that acquire molecular alterations equivalent those characterize their true somatic counterparts. However, recent studies shown typically lack the hallmark seen similar tumors....
ABSTRACTIntroduction Testicular germ cell tumors (TGCT) are the most commonly diagnosed cancers among young men. Although these usually have a good prognosis and highly treatable, clinicians pathologists still face specific dilemmas inherent to this tumor model, which is due its developmental origin.Areas Covered A wide-ranging review of currently available future prospects in field TGCT biomarkers presented.Expert Opinion The has been widely studied last decade. patients present with...
Abstract Platinum metal complexes are the most common chemotherapeutics currently used in cancer treatment. However, frequent adverse effects, as well acquired resistance by tumor cells, urge development of effective alternatives. In recent past, copper with Schiff base ligands have emerged good alternatives, showing interesting results. Accordingly, and continuation previous studies this area, three new camphoric acid‐derived halogenated salen their corresponding Cu (II) were synthesized...
Abstract Background Testicular germ cell tumors remain the most frequent solid malignancies in young males. Despite excellent prognosis, fact that only 60% of patients at diagnosis have elevated serum tumor markers (dependent on stage and histology) poor quality life who develop resistance to chemotherapy cannot be neglected. Consequently, it is mandatory bring out novel biomarkers. Objectives The main goal was evaluate EZH2 EHMT2/G9a immunoexpression a well‐characterized patients’ cohort...
Youth obesity is a strong predictor of adult obesity, which has well-known negative health consequences. Thus, addressing requires tackling youth obesity. MED4Youth's main objective to strengthen the link between Mediterranean Diet (MD) and benefits against associated cardiovascular disease (CVD) risk factors, identifying positive effects exerted by an MD including sourdough bread healthy products from basis (chickpeas/hummus, nuts, pomegranate juice). For this purpose, multicenter...
You have accessJournal of UrologyPenile & Testicular Cancer I (MP01)1 May 2024MP01-06 miRNA AS A LIQUID BIOMARKER TO DETECT MALIGNANCY IN SMALL TESTICULAR MASSES Julian Chavarriaga, Carley Langleben, João Lobo, Lucia Nappi, George M. Yousef, Sajjad Janfaza, Nuno Tiago Tavares, Qiang Ding, Adam Bobrowski, Susan Prendeville, Lynn Anson-Cartwright, Carmen Jeronimo, Heidi Wagner, Keith Jarvi, Martin O'Malley, Ricardo Leão, Katherine Lajkopsz, and Robert J. Hamilton ChavarriagaJulian Chavarriaga...
Abstract Background Testicular germ cell tumors are the most common solid malignancies in young men, with increasing incidence worldwide. Broadly classified into seminomas and non‐seminomas, they exhibit distinct biological behaviors responses to treatment. Although metabolic reprogramming is an acknowledged cancer hallmark, pathways testicular remain poorly understood. Objectives This study investigates differential expression of markers (GLUT‐1, MCT1, MCT4, LDHA, HIF‐1α) epigenetic enzyme...