A5023821271- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- HIV Research and Treatment
- Asthma and respiratory diseases
- Protein Tyrosine Phosphatases
- Eosinophilic Esophagitis
- Congenital heart defects research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Diabetes and associated disorders
- Phagocytosis and Immune Regulation
- Cytomegalovirus and herpesvirus research
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Adenosine and Purinergic Signaling
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- 14-3-3 protein interactions
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
Babraham Institute
2024
MRC Human Immunology Unit
2023
MRC Weatherall Institute of Molecular Medicine
2023
University of Oxford
2023
The Francis Crick Institute
2020-2021
MRC Laboratory of Molecular Biology
2012-2020
Medical Research Council
2012-2020
University College London
2009-2010
Interleukin-33 (IL-33) is an IL-1 family cytokine that signals via its receptor T1/ST2, and a key regulator of inflammation, notably the type-2 response implicated in allergic asthma. Critical to our understanding role IL-33 identification cellular sources IL-33. Although progress has been made this area, development robust live cell reporter expression would allow localisation during ongoing immune responses. We have generated fluorescent mouse line, Il33(Cit/+), define profile vivo...
Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) tasked with apoptotic clearance to prevent secondary necrosis and autoimmune activation by intracellular self antigens. We show multiple redundant complementary methods TBMs derive from a lymph node-resident, CD169-lineage, CSF1R-blockade-resistant precursor is prepositioned in the follicle. Non-migratory use cytoplasmic processes chase...
As obligate parasites, viruses highjack, modify and repurpose the cellular machinery for their own replication. Viral proteins have, therefore, evolved biological functions, such as signalling potential, that alter host cell physiology in ways are still incompletely understood. Retroviral envelope glycoproteins interact with several proteins, extracellularly receptor anti-envelope antibodies, intracellularly of cytoskeleton or sorting, endocytosis recirculation pathways. Here, we examined...
Type-2 immunity is characterised by interleukin (IL)-4, IL-5 and IL-13, eosinophilia, mucus production, IgE, alternatively activated macrophages (AAM). However, despite the lack of neutrophil chemoattractants such as CXCL1, neutrophils, a feature type-1 immunity, are observed in type-2 responses. Consequently, alternative mechanisms must exist to ensure that neutrophils can contribute immune reactions without escalation deleterious inflammation. We now demonstrate immune-associated...
During spinal cord development the proliferation, migration and survival of neural progenitors precursors is tightly controlled, generating fine spatial organisation cord. In order to understand better control these processes, we have examined function an orphan receptor protein tyrosine phosphatase (RPTP) PTPγ, in developing chick Widespread expression PTPγ occurs post-embryonic day 3 early consistent with a potential role either neurogenesis or neuronal maturation. Using gain-of-function...
Abstract The ubiquitin-proteasome system maintains protein homoeostasis, underpins the cell cycle, and is dysregulated in cancer. However, role of individual E3 ubiquitin ligases, which mediate final step ubiquitin-mediated proteolysis, remains incompletely understood. Identified through screening for cancer-specific endogenous retroviral transcripts, we show that little-studied ligase HECTD2 exerts dominant control tumour progression melanoma. autonomously drives proliferation human murine...
Abstract The genomes of inbred mice harbor around 50 endogenous murine leukemia virus (MLV) loci, although the specific complement varies greatly between strains. Gv1 locus is known to control transcription MLVs and be dominant determinant cell-surface presentation MLV envelope, GIX antigen. Here, we identify a single Krüppel-associated box zinc finger protein (ZFP) gene, Zfp998, as show it necessary sufficient determine GIX+ phenotype. By long-read sequencing bacterial artificial chromosome...
Abstract Differences in humoral immunity to coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), between children and adults remain unexplained the impact of underlying immune dysfunction or suppression unknown. Here, we examined antibody competence adolescents with prevalent inflammatory rheumatic diseases, juvenile idiopathic arthritis (JIA), dermatomyositis (JDM) systemic lupus erythematosus (JSLE), against seasonal human (HCoV)-OC43 that frequently...