A5045243780- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Organ Transplantation Techniques and Outcomes
- Economic and Financial Impacts of Cancer
- Breast Cancer Treatment Studies
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Biochemical Analysis and Sensing Techniques
- Sarcoma Diagnosis and Treatment
- Organ Donation and Transplantation
- Neuroendocrine Tumor Research Advances
- melanin and skin pigmentation
- Cancer Cells and Metastasis
- Microbial infections and disease research
- Cancer Treatment and Pharmacology
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Cardiac tumors and thrombi
- Gastrointestinal Tumor Research and Treatment
- Sphingolipid Metabolism and Signaling
University of Kentucky
2017-2025
University of Kentucky HealthCare
2024-2025
Markey Cancer Center
2017-2024
Access to Wholistic and Productive Living Institute
2021-2023
LabCorp (United States)
2021-2023
University of Virginia
2023
Lexington VA Health Care System
2017-2021
Covance (United States)
2020
Mallinckrodt (United States)
2020
Atrium Health Wake Forest Baptist
2020
Histoplasmosis is one of the most common mycoses endemic to United States, but it was reportable in only 10 states during 2016, when a national case definition approved. To better characterize epidemiologic features histoplasmosis, we analyzed deidentified surveillance data for 2011-2014 from following 12 states: Alabama, Arkansas, Delaware, Illinois, Indiana, Kentucky, Michigan, Minnesota, Mississippi, Nebraska, Pennsylvania, and Wisconsin. We examined laboratory calculated state-specific...
<h3>Importance</h3> Vitiligo can have profound effects on patients and is often associated with other autoimmune comorbid conditions. It important to understand the current prevalence of vitiligo, including diagnosed, undiagnosed, subtypes (nonsegmental segmental). <h3>Objective</h3> To estimate point vitiligo in US. <h3>Design, Setting, Participants</h3> For this population-based study adults US, a cross-sectional online survey was administered between December 2019 March 2020 obtain...
TPS320 Background: Ceramides and sphingosine-1-phosphate (S1P) are key bioactive signaling molecules. proapoptotic mitigate chemoresistance. Conversely, S1P promotes cancer cell proliferation, activates multiple oncogenic pathways, stimulates immuno-suppressor populations promoting a pro-tumoral microenvironment. Several studies in colorectal patients have shown high levels of ceramides associated with improved survival, while poor prognosis. Hence, modulation sphingolipid metabolism could...
PURPOSE Multidisciplinary molecular tumor boards (MTBs) interpret next-generation sequencing reports and help oncologists determine best therapeutic options; however, there is a paucity of data regarding their clinical utility. The purpose this study was to if MTB-directed therapy improves progression-free survival (PFS) over immediately prior in patients with advanced cancer. METHODS This single-arm, prospective phase II trial enrolled cancer an actionable mutation who received...
Vitiligo is an autoimmune disorder that causes patchy loss of skin pigmentation. Up to 2.16% pediatric patients may have vitiligo. This study estimated vitiligo point prevalence in children and adolescents (ages: 4-11 12-17 years) the United States (US).An online, population-based survey a nationally representative sample individuals based on 2017 US Census Bureau estimates for age, race, Hispanic origin, income, geographic region was conducted from December 2019 March 2020. Parent/legal...
Objectives We analysed near-miss and injury events reported to the National Fire Fighter Near-Miss Reporting System (NFFNMRS) investigate workplace hazards safety concerns of Emergency Medical Services (EMS) responders in USA. Methods reviewed 769 ‘non-fire emergency event’ reports from NFFNMRS using a mixed methods approach. identified 185 medical calls their narrative text fields. assigned Mechanism Near-Miss/Injury Nature Injury codes then tabulated frequencies (quantitative). coded major...
4136 Background: Mesothelin (MSLN) is overexpressed in 80-85% of pancreatic adenocarcinomas (PDAC). Anetumab ravtansine (AR) a fully human anti-MSLN immunoglobulin G1 antibody conjugated to the anti-tubulin maytansinoid DM4. Through NCI-ETCTN, North American Star Consortium conducted phase I study evaluate safety/tolerability AR various combinations patients (pts) with PDAC. Here, we report preliminary results escalation part. Methods: Pts advanced PDAC after at least one line treatment were...
Background: Most metastatic spinal cord lesions are located either in the intradural, extramedullary, or epidural compartments. Intramedullary metastasis (ISCM) is a rare central nervous system spread of cancer. The aim this report was to evaluate ISCM published literature. Methods: A literature review PubMed from 1960 2016 undertaken for publications having demographic, clinical, histological, and outcome data. Results: total 59 relevant papers were identified, showing 128 cases...
Colorectal cancer was the third most common malignancy worldwide in 2018, and patients present with or develop distant metastases. liver metastases are commonly observed because of vascular drainage colon superior rectum. Current guidelines recommend surgical resection as first-line treatment; however, 80% to 90% colorectal ineligible for primary resection. For unresectable disease, a multidisciplinary treatment approach is favored, incorporating systemic therapy toolbox local ablative...
TPS224 Background: Ceramides and sphingosine-1-phosphate (S1P) are key bioactive signaling molecules. proapoptotic mitigate chemoresistance. Conversely, S1P promotes cancer cell proliferation, activates multiple oncogenic pathways, stimulates immuno-suppressor populations promoting a pro-tumoral microenvironment. Several studies in colorectal patients have shown high levels of ceramides associated with improved survival, while poor prognosis. Hence, modulation sphingolipid metabolism could...
Abstract Background: Human epidermal growth factor receptor 2 (HER2) overexpression, amplification, or mutation occurs across a variety of solid tumors. Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has been approved by the FDA for HER2-overexpressed advanced breast, gastroesophageal cancers, HER2-low breast cancer, and HER2-mutated non-small cell lung cancer. However, some patients do not derive clinical benefit from T-DXd, drug resistance inevitable. Preclinical...
Despite recent therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with limited options. Immune checkpoint inhibitors (ICIs) have demonstrated promising results in many cancers, but thus far yielded little clinical benefit PDAC. Based on combined targeting of programmed cell death protein-1 (PD-1) and C-X-C chemokine receptor 4 (CXCR4) patient-derived xenografts (PDXs) pilot trial, we sought to elucidate potential interactions between PD-1 CXCR4. We...
Hürthle cell carcinoma (HCC) is a variant of follicular with tendency to higher frequency metastases and lower survival rate. However, intracavitary cardiac from thyroid HCC are extremely rare. We describe the case 57-year-old female HCC, 5 years after total thyroidectomy, who presented dyspnea associated hypoxia hypotension. The computed tomography angiogram showed extensive pulmonary embolism 6-cm right atrial mass while lower-extremity deep vein thrombosis studies were negative. This...