A5032181116- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Spine and Intervertebral Disc Pathology
- Nausea and vomiting management
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- Anesthesia and Neurotoxicity Research
- Congenital Heart Disease Studies
- Thermoregulation and physiological responses
- Shoulder Injury and Treatment
- Pain Mechanisms and Treatments
- Pulmonary Hypertension Research and Treatments
- Infrared Thermography in Medicine
- Tracheal and airway disorders
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Receptor Mechanisms and Signaling
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neuropharmacology Research
Tohoku University
2016-2025
Tohoku University Hospital
2014-2024
International University of Health and Welfare
2024
University of Tokyo Health Sciences
2024
Japan Society
2016
Barro Colorado Island
2016
Sapporo Medical University
2005-2014
Tokyo Medical and Dental University
2012
American Society of Anesthesiologists
2010
Oji General Hospital
2002-2004
Background: Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. However, we know little about their direct effects on exocytotic process Since exocytosis in cells can be monitored electrophysiologically by changes whole-cell membrane capacitance (Cm), absence these drugs indicates cell-stabilizing properties. Methods: Employing standard patch-clamp recording technique rat peritoneal cells, examined ketotifen Cm during exocytosis. Using...
In Brief BACKGROUND: The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant patient-controlled analgesia. METHODS: Cervical and lumbar spine surgery patients were divided into three groups: 1 mg/kg followed by 42 83 μg · kg−1 h−1 in ketamine-1 ketamine-2 group, respectively, a control group. Postoperative analgesia was administered background infusion. RESULTS: Pain scores requirement group significantly lower than those after cervical surgery....
Intraoperative motor-evoked potential (MEP) monitoring reduces postoperative motor deficits. Propofol-based total intravenous anesthesia is the gold standard for intraoperative myogenic MEPs. Although there no contraindication to administering propofol in adults with peanut, soy, or egg allergies, its safety children these allergies remains unclear.A 12-year-old girl required general under direct cortical MEP (dc-MEP) due supratentorial glioma. Remimazolam-based was selected, instead of...
Doxorubicin (Dox), an anthracycline antibiotic, is anticancer drug that inhibits DNA replication and cellular metabolic processes in cancer cells with high proliferative potential. However, Dox causes severe side effects, including myocardial damage heart failure, but the molecular mechanism underlying Dox-induced injury remains uncertain. In present study, we evaluated effects of on mitochondrial quality control system regulation respiration autophagy vitro rat myoblast H9c2 cell culture...
Abstract Background Esophagectomy is a high-risk procedure that can involve serious postoperative complications. There has been an increase in the number of minimally invasive esophagectomies (MIEs) being performed. However, relationship between intraoperative management and complications MIE remains unclear. Methods After institutional review board approval, we enrolled 300 patients who underwent at Tohoku University Hospital April 2016 March 2021. The relationships among patient...
Abstract Purpose Passive leg raising (PLR) increases intrathoracic blood volume by redistributing from the lower to upper body area. While inspiratory effort is hypothesized have a similar effect due pressure differences between and extrathoracic cavities, direct evidence scarce. Therefore, this study evaluated whether excessive using end-expiratory lung impedance (EELI). Methods Volunteers, fitted with electrical tomography (EIT) belts, underwent spontaneous breathing procedure in supine...
We investigated the clinical effects and accuracy of ultrasound-guided cervical nerve root block. Additionally, spinal level spread injected solution were confirmed by anatomic dissection fresh cadavers. DESIGN SETTING, PATIENTS, AND INTERVENTIONS: Twelve patients diagnosed with mono-radiculopathy between C5-7 underwent An insulated needle was advanced an in-plane approach using stimulation 2 mL 0.375% ropivacaine 4 mg dexamethasone stimulation. Ultrasound-guided block also performed in ten...
Podoplanin (PDPN/Aggrus/T1α/gp36/OTS-8), a type I transmembrane sialoglycoprotein, is involved in platelet aggregation, cell invasion, and cancer metastasis. expression cells or cancer-associated fibroblasts was reported to be poor prognosis of several cancers. Furthermore, podoplanin expressed lymphatic endothelial lung alveolar cells. Although many anti-podoplanin monoclonal antibodies (MAbs), such as NZ-1 D2–40, have been established, almost all MAbs are produced against...
Circulating endothelial microparticles (EMPs) are considered to be markers of injury, and lung microvascular cells express higher levels angiotensin-converting enzyme (ACE). The aim this study is examine whether the number ACE + EMPs could a prognostic marker for development acute respiratory distress syndrome (ARDS) in septic patients. numbers culture supernatant from human cells, as well blood mouse injury models patients (n=82), were examined using flow cytometry. pulmonary increased...
Background/Aims: Adrenaline quickly inhibits the release of histamine from mast cells. Besides β2-adrenergic receptors, several in vitro studies also indicate involvement α-adrenergic receptors process exocytosis. Since exocytosis cells can be detected electrophysiologically by changes membrane capacitance (Cm), its continuous monitoring presence drugs would determine their cell-stabilizing properties. Methods: Employing whole-cell patch-clamp technique rat peritoneal cells, we examined...
Thoracic epidural anesthesia (TEA) and paravertebral block (PVB) have been performed for perioperative regional in the trunk. However, TEA PVB are associated with a risk of serious complications, such as pneumothorax, hypotension, or nerve damage. Retrolaminar (RLB) was introduced new alternative to PVB. This approach might lower but its use has not well established yet. Therefore, we conducted double-masked, placebo-controlled, randomized clinical trial evaluate efficacy double-level RLB...
Objective Growing evidence suggests that endothelial injury is involved in the pathophysiology of chronic obstructive pulmonary disease (COPD). Circulating microparticles (EMPs) increase patients with COPD because presence injury. We examined relationship between EMP number and changes forced expiratory volume 1 s (FEV ) COPD. Design Prospective study. Setting One hospital Japan. Participants A total 48 outpatients stable coming to from September 2010 2011. Primary secondary outcomes...
Abstract Background Although several cross-sectional studies have reported that pain is associated with functional disability in the elderly, data regarding a longitudinal association between and are inconsistent. This study aimed to investigate of severity subsequent due all causes as well stroke, dementia, joint disease/fracture. Methods The authors conducted prospective cohort 13,702 Japanese individuals aged 65 yr or older. Information during previous 4 weeks other lifestyle factors was...
BACKGROUND: Currently, clinical indicators for evaluating endothelial permeability in sepsis are unavailable. Endothelium-derived extracellular vesicles (EDEVs) emerging as biomarkers of injury. Platelet cell adhesion molecule (PECAM) and vascular (VE)-cadherin constitutively expressed intercellular molecules that regulate permeability. Herein, we investigated the possible association between EDEVs expressing (PECAM + or VE-cadherin EDEVs) severity. METHODS: Human umbilical vein cells...
Postoperative nausea and vomiting (PONV) is a common adverse effect of anesthesia. Identifying risk factors for PONV crucial because it associated with longer stay in the post-anesthesia care unit, readmissions, perioperative costs. This retrospective study used artificial intelligence to analyze data 37,548 adult patients (aged ≥20 years) who underwent surgery under general anesthesia at Tohoku University Hospital from January 1, 2010 December 31, 2019. To evaluate PONV, experienced and/or...
<b><i>Background:</i></b> Macrolides, such as clarithromycin, have antiallergic properties. Since exocytosis in mast cells is detected electrophysiologically via changes membrane capacitance (Cm), the absence of due to drug indicates its cell-stabilizing effect. <b><i>Methods:</i></b> Employing whole-cell patch clamp technique rat peritoneal cells, we examined effects clarithromycin on Cm during exocytosis. Using a water-soluble fluorescent...
Background . Adrenaline quickly inhibits the release of histamine from mast cells. Besides β 2 ‐adrenergic receptors, several in vitro studies also indicate involvement α receptors process exocytosis. Since exocytosis cells can be detected electrophysiologically by changes membrane capacitance (Cm), its continuous monitoring presence drugs would determine their cell‐stabilizing properties. Methods Employing whole‐cell patch‐clamp technique rat peritoneal cells, we examined effects adrenaline...