A5040682298- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Language Development and Disorders
- Text Readability and Simplification
- Voice and Speech Disorders
- Amyotrophic Lateral Sclerosis Research
- Dysphagia Assessment and Management
- Parkinson's Disease Mechanisms and Treatments
- Topic Modeling
- Neurogenetic and Muscular Disorders Research
- Alzheimer's disease research and treatments
- Cerebral Palsy and Movement Disorders
- Functional Brain Connectivity Studies
- Interpreting and Communication in Healthcare
- Mental Health via Writing
- Advanced Neuroimaging Techniques and Applications
- Natural Language Processing Techniques
- Transcranial Magnetic Stimulation Studies
- Infectious Encephalopathies and Encephalitis
- Cultural Differences and Values
- Lysosomal Storage Disorders Research
- Neurological disorders and treatments
- Genetics, Aging, and Longevity in Model Organisms
- Multiple Sclerosis Research Studies
- Face Recognition and Perception
California University of Pennsylvania
2025
Penn Center for AIDS Research
2017-2024
University of Pennsylvania
2017-2024
Google (United States)
2024
Pennsylvania Academic Library Consortium
2017-2023
Philadelphia VA Medical Center
2018-2021
Tel Aviv Sourasky Medical Center
2015-2021
Hospital of the University of Pennsylvania
2018-2020
Neurology, Inc
2020
Assaf Harofeh Medical Center
2012
To test the association of antemortem CSF biomarkers with postmortem pathology in Lewy body disorders (LBD).Patients autopsy-confirmed LBD (n = 24) and Alzheimer disease (AD) 23) cognitively normal 36) controls were studied. In LBD, neuropathologic criteria defined α-synuclein (SYN) stages medium/high AD copathology (SYN + 10) low/no - 14). Ordinal scores for tau, β-amyloid (Aβ), SYN averaged across 7 cortical regions to obtain a global cerebral score each pathology. total tau (t-tau),...
Abstract Objective To automatically extract and quantify specific disease biomarkers of prosody from the acoustic properties speech in patients with primary progressive aphasia. Methods We analyzed samples 59 aphasic (non‐fluent/agrammatic = 15, semantic 21, logopenic 23; ages 50–85 years) 31 matched healthy controls (ages 54–89 years). Using a novel, automated analysis protocol, we extracted measurements prosody, including fundamental frequency silent pause durations, compared these between...
To determine whether patients with Lewy body dementia (LBD) likely Alzheimer disease (AD)-type copathology are more impaired on confrontation naming than those without AD-type copathology.
<h3>Importance</h3> Mutations in the glucocerebrosidase (<i>GBA</i>) gene are a risk factor for development of dementia with Lewy bodies (DLB). These mutations common among Ashkenazi Jews (AJ) and appear to have an effect on natural history disease. <h3>Objectives</h3> To evaluate clinical genetic characteristics AJ cohort patients diagnosed DLB, assess association phenotype DLB with<i>GBA</i>mutations, explore effects these course <h3>Design, Setting, Participants</h3> Thirty-five...
To help understand speech changes in behavioral variant frontotemporal dementia (bvFTD), we developed and implemented automatic methods of analysis for quantification prosody, evaluated clinical anatomical correlations.
We compared digital speech and language features of patients with amnestic Alzheimer disease (aAD) or logopenic variant primary progressive aphasia (lvPPA) in a biologically confirmed cohort related these to neuropsychiatric test scores CSF analytes.We included aAD lvPPA (phosphorylated tau ([p-tau]/β-amyloid [Aβ] ≥0.09, total tau/Aβ ≥0.34) autopsy confirmation AD pathology age-matched healthy controls (HC) recruited at the Frontotemporal Degeneration Center University Pennsylvania for...
ADHD is one of the most prevalent neurocognitive disorders. Deep Transcranial Magnetic Stimulation (dTMS) a non-invasive neuromodulation tool that holds promise in treatment Hypoactivity prefrontal cortex (PFC) has been observed ADHD. This study examined clinical, cognitive, and neural effects dTMS to PFC adults with by using functional magnetic resonance imaging (fMRI). High frequency repetitive was applied either right or left 62 randomized, double blind, placebo controlled protocol 3...
Purpose: Multiple methods have been suggested for quantifying syntactic complexity in speech. We compared eight automated metrics to determine which best captured verified differences between old and young adults. Method: used natural speech samples produced a picture description task by younger ( n = 76, ages 18–22 years) older 36, 53–89 healthy participants, manually transcribed segmented into sentences. that participants fewer complex structures. developed metric of using automatically...
<h3>Objective</h3> We implemented automated methods to analyze speech and evaluate the hypothesis that cognitive motor factors impair prosody in partially distinct ways patients with amyotrophic lateral sclerosis (ALS). <h3>Methods</h3> recruited 213 participants, including 67 ALS (44 ALS, 23 frontotemporal degeneration [FTD]), 33 healthy controls, neurodegenerative reference groups behavioral variant FTD (n = 90) nonfluent/agrammatic primary progressive aphasia 23). Digitized,...
Background: Progressive supranuclear palsy syndrome (PSPS) and corticobasal (CBS) as well non-fluent/agrammatic primary progressive aphasia (naPPA) are often associated with misfolded 4-repeat tau pathology, but the diversity of speech features is poorly understood. Objective: Investigate full range acoustic lexical properties to test hypothesis that PSPS-CBS show a subset impairments found in naPPA. Methods: Acoustic measures, extracted from natural, digitized semi-structured samples using...
Abstract Introduction Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials improve access to research. We studied the feasibility acceptability remote data collection FTD research using ALLFTD Mobile App (ALLFTD‐mApp). Methods A diagnostically mixed sample 214 participants with or from familial kindreds (asymptomatic: CDR®+NACC‐FTLD = 0 [ N 101]; prodromal: 0.5 49]; symptomatic ≥1 51];...
Screening for Alzheimer's disease neuropathologic change (ADNC) in individuals with atypical presentations is challenging but essential clinical management. We trained automatic speech-based classifiers to distinguish frontotemporal dementia (FTD) patients ADNC from those lobar degeneration (FTLD).
Purpose This study examines the effect of age on language use with an automated analysis digitized speech obtained from semistructured, narrative samples. Method We examined Cookie Theft picture descriptions produced by 37 older and 76 young healthy participants. Using modern natural processing automatic recognition tools, we automatically annotated part-of-speech categories all tokens, calculated number tense-inflected verbs, mean length clause, vocabulary diversity, rated nouns verbs for...
Introduction Category and letter fluency tasks are commonly used neuropsychological to evaluate lexical retrieval. Methods This study validated automated methods, which allow for more expansive investigation, analyze speech production of both category (“Animal”) (“F”) produced by healthy participants ( n = 36) on an online platform. Recordings were transcribed analyzed through pipelines, utilized natural language processing automatic acoustic tools. Automated pipelines calculated overall...
Thinking epilepsy is a rare form of reflex that can be induced by specific cognitive tasks, and occurs mainly in idiopathic generalized epilepsies. We report case complex partial seizures triggered thinking young man with acute bacterial meningitis remote head injury. This illustrates thinking-induced provoked an brain insult.
The letter-guided naming fluency task is a measure of an individual’s executive function and working memory. This study employed novel, automated, quantifiable, reproducible method to investigate how language characteristics words produced during are related performance, inter-word response time (RT), over duration using digitized F-letter-guided recordings by 76 young healthy participants. Our automated algorithm counted the number correct responses from transcripts F-letter data,...
Indirect speech acts—responding “I forgot to wear my watch today” someone who asked for the time—are ubiquitous in daily conversation, but are understudied current neurobiological models of language. To comprehend an indirect act like this one, listeners must not only decode lexical-semantic content utterance, also make a pragmatic, bridging inference. This inference allows derive speaker’s true, intended meaning—in above dialog, example, that speaker cannot provide time. In present work, we...
Abstract Background Speech is a complex activity requiring proper function and connectivity of multiple brain networks as such sensitive to focal neurodegeneration. We have previously reported on acoustic markers dysprosody in speech samples speakers with frontotemporal dementia (FTD) phenotypes. In the current study we explore longitudinal changes acoustic‐prosodic FTD. Method analyzed 102 picture descriptions from 46 participants FTD (Table 1): 8 non‐fluent/agrammatic primary progressive...
Abstract Introduction Depression and its components significantly impact dementia prediction severity, necessitating reliable objective measures for quantification. Methods We investigated associations between emotion‐based speech (valence, arousal, dominance) during picture descriptions depression dimensions derived from the geriatric scale (GDS, dysphoria, withdrawal‐apathy‐vigor (WAV), anxiety, hopelessness, subjective memory complaint). Results Higher WAV was associated with more...
Abstract Background Comorbid cognitive impairment in amyotrophic lateral sclerosis (i.e., ALS‐FTD), is associated with adverse clinical outcomes and survival. It often exhibits features of behavioral variant frontotemporal dementia (bvFTD) and/or non‐fluent agrammatic primary progressive aphasia (naPPA). Traditional assessments, such as the Edinburgh Cognitive Assessment Scale (ECAS), require trained personnel for administration. An additional repeatable, objective approach involves...