- Image Retrieval and Classification Techniques
- Medical Image Segmentation Techniques
- Image and Signal Denoising Methods
- Race, Genetics, and Society
- Speech and Audio Processing
- Neural Networks and Applications
- Advanced Vision and Imaging
- Medical History and Research
- Plant Molecular Biology Research
- Face recognition and analysis
- Advanced Image and Video Retrieval Techniques
- Plant Reproductive Biology
- AI in cancer detection
- Epigenetics and DNA Methylation
- Insect symbiosis and bacterial influences
- Image Processing Techniques and Applications
- Ion channel regulation and function
- Evolution and Genetic Dynamics
- Blood groups and transfusion
- Image and Object Detection Techniques
- Pancreatic function and diabetes
- History of Science and Medicine
- Animal Behavior and Reproduction
- Remote-Sensing Image Classification
- Plant and animal studies
University of Cambridge
2011-2023
Queen Mary University of London
2022-2023
Brown University
2023
University of East Anglia
2001-2017
Max Planck Society
2013-2016
Max Planck Institute for the History of Science
2013-2016
University of Edinburgh
2006-2011
Macmillan Cancer Support
2005
University of Calgary
2004
John Innes Centre
2004
The multimodal nature of speech is often ignored in human-computer interaction, but lip deformations and other body motion, such as those the head, convey additional information. We integrate cues from many sources this improves intelligibility, especially when acoustic signal degraded. paper shows how additional, complementary, visual information can be used for recognition. Three methods parameterizing image sequences recognition using hidden Markov models are compared. Two these top-down...
Mating induces profound changes in female insect behavior and physiology. In Drosophila melanogaster , mating causes a reduction sexual receptivity an elevation egg production for at least 5 days. Injection of the seminal fluid sex peptide (SP) both responses virgin females, but only 1–2 The role SP eliciting to remains be elucidated. Functional redundancy between components may occur. addition, with spermless males results brief (1- 2-day) post-mating responses, indicating either that there...
Although much progress has been made in understanding how gene expression patterns are established during development, less is known about these related to the growth of biological shapes. Here we describe conceptual and experimental approaches bridging this gap, with particular reference plant development where lack cell movement simplifies matters. Growth shape change plants can be fully described four types regional parameter: rate, anisotropy, direction, rotation. A key requirement...
How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have quantified shape changes during mouse heart looping, from 3D reconstructions by HREM. In combination with cell labelling and computer simulations, propose a novel model of looping. Buckling, when the cardiac tube grows between fixed poles, modulated progressive breakdown dorsal mesocardium. We identified sequential asymmetries at which bias buckling in opposite directions, thus leading to helical shape. Our...
A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, size, shape, and shape. Explaining these presents a challenge because their dynamics cross-correlations, which can make it difficult to disentangle causes from effects. To address problems, we used live imaging determine the leaf growth division in different genetic tissue contexts. In simplifying background speechless (spch) mutant, lacks stomatal lineages, epidermal layer defined along proximodistal...
The mechanisms by which genes control organ shape are poorly understood. In principle, may modifying local rates and/or orientations of deformation. Distinguishing between these possibilities has been difficult because interactions patterns, orientations, and mechanical constraints during growth. Here we show how a combination growth analysis, molecular genetics, modelling can be used to dissect the factors contributing shape. Using Snapdragon (Antirrhinum) flower as an example, development...
Lipids were obtained from high potassium (HK) and low (LK) sheep red cells by sequential extraction of the erythrocytes with isopropanol-chloroform, chloroform-methanol-0.1 M KCl, chloroform. The extract contained cholesterol phospholipid in a molar ratio 0.8:1.0, less than 1% protein contaminant. Stable thin lipid membranes separating two aqueous compartments formed an erythrocyte lipid-hydrocarbon solution, had electrical resistance ∼108 ohm-cm2 capacitance 0.38–0.4 µf/cm2. From values,...
Arthur Mourant's The Distribution of the Human Blood Groups (1954) was an "indispensable" reference book on "anthropology blood groups" containing a vast collection human genetic data. It based results blood-grouping tests carried out half-a-million people and drew together studies diverse populations around world: from rural communities, to religious exiles, volunteer transfusion donors. This paper pieces sequential stages in production small fraction blood-group data book, examine how he...
Out-of-plane tissue deformations are key morphogenetic events during plant and animal development that generate 3D shapes, such as flowers or limbs. However, the mechanisms by which spatiotemporal patterns of gene expression modify cellular behaviours to remain be established. We use Snapdragon flower a model system address this problem. Combining analysis with tissue-level modelling, we show an orthogonal pattern growth orientations plays role in generating out-of-plane deformations. This...
Abstract Collections are made and maintained for pleasure, status, nation or empire building, cultural capital, as a substrate knowledge production everything in between. In asking how collections end, we shift the focus from acquisition growth to erosion, loss decay, expose intellectual, material curatorial labour required maintain collections. this introductory essay, draw together insights history of science technology studies investigate dispersal, destruction, absorption, repurposing...
The theory of an image decomposition that we refer to as a sieve is developed for images defined in any finite number dimensions. has many desirable properties including the preservation scale-space causality and localization sharp-edged objects transformation domain. additional manipulability, which means it easy construct pattern recognition systems, scale-calibration, may be used accurate measurement.
We present an outline of the technical aspects recently started ViSiCAST project, which aims to provide deaf citizens with improved access services and facilities through sign language. first give overview main application areas, before considering in more detail two areas supporting technology development: language notation, virtual human signing.
The development of organs with particular shapes, like wings or flowers, depends on regional activity transcription factors and signalling molecules. However, the mechanisms that link these molecular activities to morphogenetic events underlying shape are poorly understood. Here we describe a combination experimental computational approaches address this problem, applying them group genes controlling flower in Snapdragon (Antirrhinum). Four known play key role control floral asymmetry...