A5101680831- Immune Cell Function and Interaction
- Geological formations and processes
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Geological and Geophysical Studies
- Hydrocarbon exploration and reservoir analysis
- Geology and Paleoclimatology Research
- Cancer Immunotherapy and Biomarkers
- Maternal Mental Health During Pregnancy and Postpartum
- Child Abuse and Trauma
- Child and Adolescent Psychosocial and Emotional Development
- Bone and Joint Diseases
- Geological Studies and Exploration
- Glycosylation and Glycoproteins Research
- Natural product bioactivities and synthesis
- Bone health and osteoporosis research
- Seismic Imaging and Inversion Techniques
- Microbial infections and disease research
- Cancer-related molecular mechanisms research
- Multiple Myeloma Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- T-cell and Retrovirus Studies
- Hematopoietic Stem Cell Transplantation
- Pharmacological Effects of Natural Compounds
- Infant Development and Preterm Care
City Of Hope National Medical Center
2020-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
Jilin University
2023-2024
China University of Geosciences
2020-2024
Zhejiang University
2024
Shanghai University of Traditional Chinese Medicine
2023
Jilin Medical University
2023
City of Hope
2021-2022
Nanjing Agricultural University
2019
Abstract Engineered natural killer (NK) cells represent a promising option for immune therapy due to their immediate availability in allogeneic settings. Severe acute diseases, such as COVID-19, require targeted and intervention. Here we show engineering of NK express (1) soluble interleukin-15 (sIL15) enhancing survival (2) chimeric antigen receptor (CAR) consisting an extracellular domain ACE2, targeting the spike protein SARS-CoV-2. These CAR (mACE2-CAR_sIL15 cells) bind VSV-SARS-CoV-2...
The majority of patients with acute myeloid leukemia (AML) succumb to the disease or its complications, especially among older patients. Natural killer (NK) cells have been shown antileukemic activity in AML; however, our knowledge, primary NK armed a chimeric antigen receptor (CAR) targeting antigens associated AML as an "off-the-shelf" product for control not explored. We developed frozen, off-the-shelf allogeneic human engineered CAR recognizing FLT3 and secreting soluble interleukin-15...
Pancreatic ductal adenocarcinoma cancer (PDAC) continues to pose a significant health burden, with 5-year survival rate of only 10%. Prostate stem cell antigen (PSCA) is highly expressed on the surface tumor cells most PDAC patients, minimum expression in normal tissues. Here, we generated cryopreserved, off-the-shelf, allogeneic PSCA chimeric receptor (CAR) invariant NKT (iNKT) using human peripheral blood mononuclear as source. In multiple vitro and vivo models, freshly manufactured...
Adverse Childhood Experiences (ACEs) may have an impact on cognitive disability through multiple pathways. Frequent Mental Distress (FMD) could result in different aspects, but the potential mediating role of FMD associations remained unclear. So we aimed to investigate not only association between self-reported ACEs and disability, also effect disability. A cross-sectional analysis respondents aged 18–25 years old 2020 2021 Behavioral Risk Factor Surveillance System (BRFSS) was performed....
Pancreatic cancer (PC), the third leading cause of cancer-related death in U.S., is frequently found too late to be cured by traditional chemotherapy. Expression B7 homolog 6 (B7H6), a member family immunoreceptors, has been PC and several other cancers. B7H6 ligand for cytotoxicity triggering receptor 3 (NKp30), which expressed on NK cells. Here, we demonstrate that can detected tissues but not normal organs. Its expression patients associated significantly with tumor differentiation grade...
To explore the therapeutic mechanism of Liushen Wan (LSW) against colitis-associated colorectal cancer (CAC) by network pharmacology.TCMSP, BATMAN-TCM, CNKI, PubMed, Genecards, OMIM, and TTD databases were used to obtain related targets LSW CAC. The common CAC obtained using Venny online website. PPI was constructed Cytoscape 3.8.2 screen core in treatment GO KEGG enrichment analysis conducted DAVID database. effect on evaluated a C57BL/6J mouse model AOM/DSS-induced observing changes body...
The Pearl River Mouth Basin (PRMB), located on the northern margin of South China Sea (SCS), contains a significant number Early Miocene (17.25-14.8 Ma) shelf delta deposits. characteristics these deposits, including their type, thickness, and distribution, are influenced by basement geomorphology sea level fluctuations within relatively shallow Zhu-1 Depression. Based newly acquired 3D seismic data 37 pre-existing wells, it has been seen that distinct geomorphic units, both positive...
Abstract Recently developed therapeutics for multiple myeloma (MM) include targeted therapy, immunomodulatory drugs, and immunotherapy, the latter of which consists B-cell maturation antigen (BCMA)-CAR cells, bispecific antibodies (BsAbs) to engage T cells. However, challenges including relapse toxicity still exist. The orphan G protein-coupled receptor, class C group 5 member D (GPRC5D), emerged as a novel target MM therapy. Therefore, following our established system [Cancer Immunol Res...
In post-rift basins, the thickness center, fine-grained deposit and subsidence center rarely converge. Clearing three centers with thickest is difficult. Huangyan district of Xihu Sag, East China Sea Shelf Basin, an Oligocene basin beneath major potential igneous provinces, has inconsistent composition. Analysis core samples, drilling, 3D seismic data corroborated this finding. This means that formation does not match lithology which indicates water depth. Gravity magnetic measurements in...
摘要: 阳江凹陷作为珠江口盆地西北部浅水边缘盆地珠三坳陷内次级负向构造单元，具有周缘隆起带及局部凸起障壁环境，中新世时期（19.1~13.8 Ma）阳江-一统断裂带两侧火山活动发育，研究区发育港湾状地貌限定下半封闭潮控海岸-河口湾背景.珠三坳陷勘探成熟的多为构造圈闭，而对于岩性圈闭的识别刻画研究尚处在起步阶段，其中阳江凹陷已发现6个含油构造，并部署19口钻井，具有良好的资料基础，中新统缺乏岩性潜力系统研究认识，地层岩性圈闭搜索、排序及优选亟待开展.应用钻测井资料、岩心资料和新采集三维地震资料，基于区域构造-火山活动背景，在高精度层序格架搭建和沉积充填序列框架上，聚焦于阳江凹陷潮控体系沉积特征、沉积相展布及演化规律，进而解剖潮控体系下潮汐砂坝的识别标志、分布规律及岩性圈闭发育特征.研究表明：阳江东凹中新统发育潮控河口湾-潮控三角洲沉积体系，有利岩性圈闭叠合区恩平2-8构造储集砂体为潮汐砂坝，对于珠江口盆地浅水区域潮控体系及岩性圈闭预测具重要理论与勘探意义，并为其他浅水边缘盆地岩性圈闭研究提供了参考借鉴. 关键词: 阳江凹陷 / 中新统 潮控体系 潮汐砂坝 岩性圈闭 油气
Abstract Non-small cell lung cancer (NSCLC) remains one of the major causes related mortality worldwide, yet clinical advances with checkpoint inhibitors suggest that an anti-tumor immune response can be harnessed to prolong survival in NSCLC patients. We recently described identification a tumor reactive natural killer (NK) population by its vivo upregulation PD-L1 presence tumor, referred here as TRACK-NK cells. PD-L1(+) NK cells are more potent than PD-L1(-) against targets. Further,...
摘要: 旋回地层学的研究对象由海相地层逐渐转移到陆相深水地层.为了探究通过旋回地层学研究方法在陆相浅水湖盆建立高频层序格架的可能，采用频谱分析、天文调谐、“米氏”沉积速率拾取等手段对东海陆架盆地西湖凹陷黄岩区渐新统坳陷湖盆的岩相敏感曲线-GR数据开展研究.频谱分析结果显示黄岩区花港组受405 ka长偏心率周期（E）、121 ka和97 ka短偏心率周期（e）、28 ka斜率周期（O）以及约22 ka岁差周期（P）的调控.在浅水湖泊环境的富泥区，以La2004天文解决方案给出的65°N平均日照序列为参照进行天文调谐，建立了浮动天文年代标尺；在浅水三角洲环境的富砂区，通过滑动窗口频谱分析得到“米氏”沉积速率曲线，结合锆石铀铅测年资料的校验和岩石组合类型联合约束，完成高频层序格架划分.研究表明：黄岩区花港组持续时间约为10.9 Ma，可识别出27个405 ka长偏心率周期，根据偏心率滤波曲线和日照量各级次包络面的对应关系共划分11个四级层序，27个五级层序，分别对应着0.8~1.6 Ma和0.4...
Abstract Background Adverse Childhood Experiences (ACEs) may have an impact on cognitive disability through multiple pathways. Frequent Mental Distress (FMD) usually makes people more susceptible to dysfunction different aspects. Methods A cross-sectional analysis of aged 18–25 years in the 2020 and 2021 Behavioral Risk Factor Surveillance System (BRFSS) was performed. Weighted multivariate logistic regression models were used assess association ACEs with FMD disability. Mediation effects...
摘要: 依托洋陆边缘第四纪以来的解剖经验,源-汇系统研究已对陆相裂陷盆地开展深时探索实践,是当前国际沉积学研究的前沿领域,其中,涉及源-汇系统研究尺度与级次、物源区地貌演化与沉积碎屑产出、路径系统信号传递与示踪、多因素联合控制沉积-层序发育等关键问题亟待解决.针对上述问题,提出了火山作用改造沉积序列、古气候-植被群落调控风化效能、形态学与物源供给响应关联、路径系统交互模型预测、古水深-水动力制约砂体分散、正演模拟恢复源-汇过程及碳酸盐岩溶解质源-汇响应等潜在的革新方向,以期解决陆相裂陷盆地深时多驱动因素、多交互介质影响下沉积通量拾取及平衡恢复问题.此外,建议从多学科交叉融合及深时大数据系统多要素构建两方面拓展中国特色陆相深时源-汇系统研究内涵,服务能源矿产勘探预测. 关键词: 陆相深时源-汇系统 / 地貌形态 沉积信号 古气候-水体环境 大数据 关键问题 革新方向 沉积学
<h3>Background</h3> Expression of PD-L1 on human natural killer (NK) cells identifies a subset that are selectively reactive to tumors. PD-L1(+) NK have increased CD107a expression, cytotoxicity, and interferon-gamma secretion vs. the PD-L1(-) fraction. manufactured for patient administration using cytokine stimulation under GMP conditions in vivo survival sustained by engineering these tumor-reactive, cytokine-induced (TRACK) express soluble (s)IL-15. Cryopreserved, off-the-shelf allogeneic...
Abstract Pancreatic cancer (PC) is one of the most lethal forms with a 5-year overall survival rate 9%, routinely presenting as late-stage incurable that responds only modestly to standard chemotherapy. It third leading cause cancer-related deaths. Approximately 60-80% PC express prostate stem cell antigen (PSCA), do gastric, bladder, and some lung cancers. We therefore developed chimeric receptor (CAR) directed against PSCA for transduction into human natural killer (NK) cells. NK cells...