A5010760354- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Telomeres, Telomerase, and Senescence
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Dietary Effects on Health
- Eosinophilic Disorders and Syndromes
- Health, Environment, Cognitive Aging
- Genetics, Aging, and Longevity in Model Organisms
- Cancer therapeutics and mechanisms
- Genomics and Phylogenetic Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Hematological disorders and diagnostics
- Seaweed-derived Bioactive Compounds
- Synthesis and pharmacology of benzodiazepine derivatives
- Microbial Inactivation Methods
- Spondyloarthritis Studies and Treatments
- Cytomegalovirus and herpesvirus research
- Bee Products Chemical Analysis
- Glycosylation and Glycoproteins Research
- Biochemical and Molecular Research
Children's Hospital of Philadelphia
2023-2025
University of Pennsylvania
2025
Lurie Children's Hospital
2022
Northwestern University
2022
Bowdoin College
2020
Dana-Farber Cancer Institute
2016-2019
Harvard University
2019
Cedars-Sinai Medical Center
2019
Harvard University Press
2017
University of Washington
2011
Background Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual directly influence risk. We addressed this question using genetic markers as proxies for putative risk and evaluated their relation to RCC in a mendelian randomization (MR) framework. This methodology limits bias due confounding not affected by reverse causation. Methods findings Genetic obesity measures, blood pressure, lipids, type 2 diabetes, insulin, glucose...
ABSTRACT This single‐institution retrospective cohort study evaluates the risk of thromboembolic events (TE) in patients with juvenile dermatomyositis (JDM) treated intravenous immunoglobulin (IVIg). We found no difference occurrence TE JDM IVIg as compared to those without exposure; both cohorts had TEs. Patients matched levels other clotting factors, such periods limited mobility and hormonal contraceptive use. research supports growing body evidence adult DM population demonstrating...
High ferritin is an important and sensitive biomarker for the diverse deadly group of cytokine storm syndromes grouped together under term hemophagocytic lymphohistiocytosis. Early identification syndrome its contributors are critical to guiding targeted treatments preventing immunopathology, morbidity, mortality. Unfortunately, we lack specific diagnostic biomarkers, which complicates etiologic workup delays intervention. Through implementing a hyperferritinemia alert system, hoped identify...
Bacterial cell surface glycans are quintessential drug targets due to their critical role in colonization of the host, pathogen survival, and immune evasion. The dense envelope glycocalyx contains distinctive monosaccharides that stitched together into higher order yield exclusively bacterial structures for strain fitness pathogenesis. However, systematic study inhibition glycosylation enzymes remains challenging. Bacteria produce containing rare sugars refractory traditional glycan...
Determining the function of non-coding regulatory variants in cancer is a key challenge transcriptional biology. We investigated genetic (germline and somatic) determinants mechanisms renal cell carcinoma (RCC) using H3K27ac ChIP-seq data 10 matched tumor/normal samples RNA-seq from 496/66 The Cancer Genome Atlas (TCGA). Unsupervised clustering activity cleanly separated tumor normal individuals, highlighting extensive epigenetic reprogramming during transformation. developed novel method to...
Abstract High ferritin is an important and sensitive biomarker for the various forms of hemophagocytic lymphohistiocytosis (HLH), a diverse deadly group cytokine storm syndromes. Early action to prevent immunopathology in HLH often includes empiric immunomodulation, which can complicate etiologic work-up collection early/pre-treatment research samples. To address this, we instituted alert system at UPMC Children’s Hospital where serum > 1000 ng/mL triggered real-time chart review,...
Tocilizumab is reported to reduce systemic inflammation in individuals with SLC29A3 spectrum disorder, but its effect on hearing loss has not been described. The authors present a boy toddler history of prematurity, dysphagia, hypersplenism, hyperpigmentation, short height and who was referred the immunology clinic. He initially presented shortly after birth abnormal screens followed by positive urine test for cytomegalovirus. However, infection determined be postnatally acquired most likely...
<title>Abstract</title> High ferritin is an important and sensitive biomarker for hemophagocytic lymphohistiocytosis (HLH), a diverse deadly group of cytokine storm syndromes. Early action to prevent immunopathology in HLH often includes empiric immunomodulation, which can complicate etiologic work-up collection early/pre-treatment research samples. To address this, we instituted alert system where serum > 1000ng/mL triggered real-time chart review, assessment whether the value reflected...