A5012241827- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Parasitic Infections and Diagnostics
- Parasites and Host Interactions
- Amoebic Infections and Treatments
- Research on Leishmaniasis Studies
- Pneumonia and Respiratory Infections
- Parasitic infections in humans and animals
- COVID-19 Clinical Research Studies
- Parasite Biology and Host Interactions
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Insect behavior and control techniques
- Trypanosoma species research and implications
- Forensic Entomology and Diptera Studies
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Microplastics and Plastic Pollution
- Respiratory viral infections research
- Insect symbiosis and bacterial influences
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Bacterial Infections and Vaccines
- Ginseng Biological Effects and Applications
- Tuberculosis Research and Epidemiology
Bambino Gesù Children's Hospital
2018-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
ETH Zurich
2021
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2012-2018
Center for Prevention and Treatment of Infections
2014
This is the first study on gut microbiota (GM) in children affected by coronavirus disease 2019 (COVID-19). Stool samples from 88 patients with suspected severe acute respiratory syndrome 2 (SARS-CoV-2) infection and 95 healthy subjects were collected (admission: 3–7 days, discharge) to GM profile 16S rRNA gene sequencing relationship severity. The group was divided COVID-19 (68), Non–COVID-19 (16), MIS-C (multisystem inflammatory children) (4). Correlations among ecology, predicted...
Introduction Since the beginning of SARS-CoV-2 pandemic in early 2020, it has been apparent that children were partially protected from both infection and more severe forms disease. Many different mechanisms have proposed to explain this phenomenon, including children’s frequent exposure other upper respiratory infections vaccines, which inflammatory cytokines they are likely produce response infection. Furthermore, given presence intestine its ability infect enterocytes, combined with well...
Background Human cystic echinococcosis (CE) is a zoonotic parasitic infection caused by the larval stage of species belonging to Echinococcus granulosus sensu lato ( s . l .) complex. Parasitic cysts causing human CE are mainly localized in liver and lungs. In smaller number cases, larvae may establish any organ or tissue, including central nervous system (CNS). Cerebral (CCE) rare but poses serious clinical challenges. Methods This study presents case CCE child living countryside near Rome...
Pneumonia caused by Pneumocystis jirovecii infection (PCP) is a potentially life-threatening illness, particularly affecting the immunocompromised. The past two decades have shown an increase in PCP incidence; however, underlying factors that promote disease severity and fatality yet to be fully elucidated. Recent evidence suggests microbiota of respiratory tract may play role stimulating or repressing pulmonary inflammation, as well progression both bacterial viral pneumonia. Here, we...
Cryptosporidium spp. are zoonotic protozoan parasites with a global prevalence, both gastrointestinal and pulmonary involvement. Though symptoms can often be relatively mild, they become severe even fatal in children under five, the elderly, immunocompromised individuals, making cryptosporidiosis leading cause of morbidity mortality fragile populations. Furthermore, there is an urgent clinical need for alternative therapies against cryptosporidiosis, as currently available FDA-approved...
Anisakiasis is nowadays a well-known infection, mainly caused by the accidental ingestion of Anisakis larvae, following consumption raw or undercooked fishes and cephalopods. Due to similarity symptoms with those common gastrointestinal disorders, this infection often underestimated, need for new specific diagnostic tools becoming crucial. Given remarkable impact that MALDI–TOF MS biotyping had in last decade clinical routine practice recognition bacterial fungi strains, similar scenario...
Ischemic stroke (IS) can be caused by perturbations of the gut–brain axis. An imbalance in gut microbiota (GM), or dysbiosis, may linked to several IS risk factors and influence brain through production different metabolites, such as short-chain fatty acids (SCFAs), indole derivatives. This study examines ecological changes GM its metabolic activities after stroke. Fecal samples 10 patients were compared 21 healthy controls (CTRLs). profiles generated via 16S rRNA taxonomy functional using...
Background . Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, country of medium to high endemicity, remains poorly defined, as notification has long ceased be mandatory. Methods We set up retrospective cohort study involving all CE patients followed at our institute between January 2005 December 2012. Demographical clinical features were recorded analyzed. Results was found 28 (64.3%), mostly Italians from the central regions (50%),...
Chagas disease (CD) is a systemic parasitic infection caused by the protozoan Trypanosoma cruzi, whose chronic phase may lead to cardiac and intestinal disorders. Endemic in Latin America where it transmitted mainly vectors, large-scale migrations other countries have turned CD into global health problem because of its alternative transmission routes through blood transfusion, tissue transplantation, or congenital. Aim this study was compare performance two commercially available tests for...
The relationship between COVID-19 and nasopharyngeal (NP) microbiota has been investigated mainly in the adult population. We explored NP profile of children affected by COVID-19, compared to healthy controls (CTRLs). swabs with collected March September 2020, were at admission (
Congenital malaria is usually defined as the detection of asexual forms Plasmodium spp. in a blood sample neonate during perinatal age if there no possibility postpartum infection by mosquito bite. The incidence congenital highly variable and seems related to several factors, such different diagnostic methods for detection, area which epidemiologic analyses are performed. In non-endemic countries, cases rare. Hereby, case an HIV exposed child reported. A 2-month-old male was admitted Bambino...
Background: Strongyloidiasis is a neglected tropical disease caused by the intestinal nematode Strongyloides stercoralis and characterized gastrointestinal pulmonary involvement. We report pediatric case of strongyloidiasis to underline response host microbiota perturbation induced nematode. Methods: performed 16S rRNA-metagenomic analysis gut 7-year-old female during after S. stercolaris infection, investigating three time-point stool samples’ ecology: T0- parasite T1- month T2- two months...
Cryptosporidium parvum is a protozoan parasite and one of the leading causes gastroenteritis in world, primarily affecting very young children immunocompromised patients. While infection usually self-limiting, it can become chronic even lethal these vulnerable populations, whom treatments are generally ineffective, due to their acting concert with functioning immune system. Here, we describe case cryptosporidiosis European child severe CD40L immunodeficiency infected IIa20G1 subgenotype,...
Background: The diagnosis of schistosomiasis is usually based on clinical data associated with the detection eggs in stool, urine, and/or rectal and bladder biopsy specimens. However antibody can be useful to indicate Schistosoma infection those for whom cannot demonstrated. aim this study was assess seroprevalence evaluate accuracy indirect haemagglutination (IHA) Western blot (WB) assays anti-Schistosoma antibodies 2 peripheral hospitals United Republic Tanzania. Methods: Between February...
Introduction The gut microbiota (GM) play a significant role in the infectivity and severity of COVID-19 infection. However, available literature primarily focuses on adult patients it is known that undergoes changes throughout lifespan, with alterations occurring during infancy subsequently stabilizing adulthood. Moreover, children have exhibited milder symptoms disease, which has been associated abundance certain protective bacteria. Here, we examine metaproteome pediatric to uncover...
infection (CDI) is generally treated with vancomycin, metronidazole or fidaxomicin, although fecal microbiota transplantation (FMT) represents a promising therapeutic option for antibiotic-resistant recurrent