A5102824713- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Growth Hormone and Insulin-like Growth Factors
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
- Genetic Syndromes and Imprinting
- Prostate Cancer Treatment and Research
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Protease and Inhibitor Mechanisms
- Ion channel regulation and function
- Retinal Development and Disorders
- Prostate Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Infrared Thermography in Medicine
- Heart Rate Variability and Autonomic Control
- Thermal Regulation in Medicine
- Renal Diseases and Glomerulopathies
- Congenital heart defects research
- Retinal Diseases and Treatments
Università Cattolica del Sacro Cuore
2022-2025
Agostino Gemelli University Polyclinic
2024
Science & Technology Park (Czechia)
2024
Institute for Systems Analysis
2024
National Academies of Sciences, Engineering, and Medicine
2024
University of Pisa
2018-2019
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2002
University of Milan
1997-1999
Azienda Ospedaliera San Gerardo
1999
Cirrhosis is associated with cardiovascular abnormalities. Scanty information available as to whether these include left ventricle diastolic dysfunction and wall thickness increase. To this aim in 27 cirrhotic patients tense ascites, 17 previous episodes of ascites (not actual), 11 controls we investigated by echocardiography echocolor Doppler function (E wave, A E/A ratio, deceleration time E wave), systolic (ejection fraction), (left posterior + interventricular septum thickness) along...
Insulin-resistance-associated hepatic iron overload syndrome (IRHIO) is characterized by high serum ferritin and presence of metabolic alterations that are part insulin-resistance (IRS). Thus, clinical conditions a prevalence IRS may also be IRHIO.We studied 88 consecutive patients with essential hypertension, 62 IRHIO 102 healthy normotensive controls. Hemochromatosis, other able to induce secondary or increase unrelated body stores were excluded. Iron indices, profiles tests in...
Abstract Background About 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need for development innovative therapies. In this direction, potential research focus might be on long non-coding RNAs (lncRNAs) like H19, which serve critical biological functions and show significant dysregulation in cancer. Previously, we showed a transcriptional down-regulation H19 under combined pro-tumoral estrogen hypoxia treatment...
The alteration of the lysine acetyltransferase activity and protein‐protein interactions transcriptional co‐activators CBP p300 is linked to development both solid haematological cancers. To target functions CBP/p300, we developed two PROTAC‐based chemical degraders by linking CBP/p300 catalytic inhibitor C646 CRBN ligand thalidomide via PEG‐based linkers. Both compounds exhibited submicromolar inhibition decreased their levels in SU‐DHL‐10 lymphoma cell line at low‐micromolar...
Abstract The urokinase‐type plasminogen activator ( uPA ) receptor uPAR participates to the mechanisms causing renal damage in response hyperglycaemia. main function of podocytes (as well as soluble ‐(s)u PAR ‐ from circulation) is regulate podocyte through αvβ3 integrin/Rac‐1. We addressed question whether blocking pathway with small peptide UPARANT , which inhibits binding formyl receptors FPR s) can improve kidney lesions a rat model streptozotocin STZ )‐induced diabetes. concentration...
It has been recently established that GPR158, a class C orphan G protein-coupled receptor, serves as metabotropic glycine receptor. GPR158 is highly expressed in the nucleus accumbens (NAc), major input structure of basal ganglia integrates information from cortical and subcortical structures to mediate goal-directed behaviors. However, whether modulates neuronal activity NAc through activation not investigated yet. Using whole-cell patch-clamp recordings, we found glycine-dependent...
Histaminergic neurons are exclusively located in the hypothalamic tuberomammillary nucleus, from where they project to many brain areas including nucleus accumbens (NAc), a area that integrates diverse monoaminergic inputs coordinate motivated behaviours. While NAc expresses various histamine receptor subtypes, mechanisms by which modulates activity still poorly understood. Using whole-cell patch-clamp recordings, we found pharmacological activation of 2 (H2) receptors elevates excitability...
Abstract Retinitis pigmentosa (RP) is characterized by progressive loss of vision due to photoreceptor degeneration leading secondary inflammation. The urokinase‐type plasminogen activator (uPA) system contributes retinal inflammation, but its role in RP unknown. In the rd10 mouse model RP, we addressed this question with use peptide UPARANT designed interact uPA system. was systemically administered from post‐natal day (PD) 10 PD30 when efficacy rescue investigated using...
Abstract Purpose This study explores the potential for hidden variations within seemingly uniform regions of growth hormone -secreting pituitary neuroendocrine tumors (GH-PitNETs). We employed archived tissue samples using Laser Capture Microdissection Sequencing (LCM-RNAseq) to probe molecular landscape these at a deeper level. Methods A customized protocol was developed extract, process, and sequence small amounts RNA from formalin-fixed, paraffin-embedded (FFPE) tissues derived five...
Abstract In the complex tumor biology of prostate cancer (PCa), we previously contributed by demonstrating that estrogen receptor and hypoxia signaling promoted transcription progression-associated genes. Notably, combined treatment, estrogens plus hypoxia, caused a significant down regulation long noncoding RNA H19, one most sensitive to these pro-tumoral stimuli. Mechanistically, H19 acts as transcriptional repressor: over-expression decreases E-cadherin (CDH1) level causing...
Metastatic prostate cancer (PCa) presents a significant challenge in oncology due to its high mortality rate and the absence of effective biomarkers for predicting patient outcomes. Building on previous research that highlighted critical role long noncoding RNA (lncRNA) H19 cell adhesion molecules promoting tumor progression under hypoxia estrogen stimulation, this study aimed assess potential these components as prognostic PCa at biopsy stage.
This study explores the potential for hidden variations within seemingly uniform regions of growth hormone-secreting pituitary neuroendocrine tumors (GH-PitNETs). We employed archived tissue samples using Laser Capture Microdissection Sequencing (LCM-RNAseq) to probe molecular landscape these at a deeper level.
Abstract Background About 30% of Prostate cancer (PCa) patients progress to metastatic PCa that remains largely incurable. This evidence underlines the need for development innovative therapies. In this direction, potential research focus might be on long non-coding RNAs (lncRNAs) like H19, which serve critical biological functions and show significant dysregulation in cancer. Previously, it has been shown noncoding RNA H19 acts as transcriptional repressor cell adhesion molecules affecting...