A5019671472- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Acne and Rosacea Treatments and Effects
- Higher Education Teaching and Evaluation
- Pharmaceutical studies and practices
- Phytochemistry and Biological Activities
- Salivary Gland Disorders and Functions
- E-Learning and Knowledge Management
- Natural product bioactivities and synthesis
- Inflammatory mediators and NSAID effects
- Ocular Diseases and Behçet’s Syndrome
- Educational Technology in Learning
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Contact Dermatitis and Allergies
- Proteoglycans and glycosaminoglycans research
- Analytical Methods in Pharmaceuticals
Universitat de Barcelona
2013-2025
Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona
2017-2025
The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix deliver methotrexate (MTX) colon. primed were subjected evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic porosity using an acidic (pH 1.2) phosphate buffer (PBS) 6.8 & pH 7.4) media. Fourier transform infrared spectroscopy (FTIR) thermal gravimetric analysis (TGA) performed the chemical compatibility of hydrogel. shape alteration release hydrogel conducted at 1.2, 7.4. drug...
The absorption study of drugs through different biological membranes constitutes an essential step in the development new pharmaceutical dosage forms. Concerning orally administered forms, methods based on monolayer cell culture Caco-2 (Caucasian colon adenocarcinoma) have been developed to emulate intestinal mucosa permeability studies. Although it is widely accepted, has disadvantages, such as high costs or technical complexity, and limitations related simplified structure class molecules...
The purpose of the present study was to develop emulsions encapsulated by chitosan on outer surface a nano droplet containing 5-fluorouracil (5-FU) as model drug. were characterized in terms size, pH and viscosity evaluated for their physicochemical properties such drug release skin permeation vitro. tween 80 (T80), sodium lauryl sulfate, span 20, combination polyethylene glycol (PEG) T20 exhibited 88%, 86%, 90% 92%, respectively. Chitosan-modified considerably controlled 5-FU compared...
Thyme oil (THO) possesses excellent antibacterial and antioxidant properties which are suitable for skin inflammatory disorders such as acne vulgaris. However, THO is insoluble in water its components highly volatile. Therefore, these drawbacks may be overcome by encapsulation biodegradable PLGA nanoparticles (THO-NPs) that had been functionalized using several strategies. Moreover, cell viability was studied HaCat cells, confirming their safety. In order to assess therapeutic efficacy...
Purpose: Acne vulgaris is one of the most prevalent dermal disorders affecting skin health and appearance. To date, there no effective cure for this pathology, majority marketed formulations eliminate both healthy pathological microbiota. Therefore, hereby we propose encapsulation an antimicrobial natural compound (thymol) loaded into lipid nanostructured systems to be topically used against acne. Methods: address issue, carriers (NLC) capable encapsulating thymol, a treatment acne vulgaris,...
Rosacea is a common skin condition with quite relevance. It currently affects at least 10% of the European population some point after age 30. chronic disorder that mainly on face and characterized by outbreaks remissions. Under normal circumstances, presents wide range commensal organisms, such as Staphylococcus epidermidis or Demodex folliculorum, but dysbiosis flora plays relevant role in inflammatory processes development disease. Metronidazole (MD) one main treatments indicated to...
Background: Alopecia areata is an autoimmune disorder that causes hair loss in clumps about the size and shape of a quarter. The estimated prevalence approximately 1 1000 people, with lifetime risk 2 percent. One systemic therapies for alopecia consists use glucocorticoids or immunosuppressants. Methods: Baricitinib (BCT) Janus kinase (JAK) selective inhibitor used as immunosuppressant drug. In this study, three olive oil BCT formulations (Oil A, Oil B, C, which differ their content...
Condyloma acuminata is an infectious disease caused by the human papilloma virus (HPV) and one of most common sexually transmitted infections. It manifested as warts that frequently cause pain, pruritus, burning, occasional bleeding. Treatment (physical, chemical, or surgical) can result in erosion, scars, ulcers, implying inflammatory processes causing pain. In this work, a biocompatible topical hydrogel containing 2% ketorolac tromethamine was developed to manage painful occurring upon...
Wound healing is a natural physiological reaction to tissue injury. Hydrogels show attractive advantages in wound not only due their biodegradability, biocompatibility and permeability but also because provide an excellent environment for cell migration proliferation. The main objective of the present study was design characterization hydrogel loaded with human mesenchymal stromal cells (hMSCs) use would superficial skin injures. Poloxamer 407® used as biocompatible biomaterial embed hMSCs....
Pranoprofen (PRA)-loaded nanostructured lipid carriers (NLC) have been dispersed into blank gels composed of 1% Carbomer 940 (PRA-NLC-Car) and 3% Sepigel® 305 (PRA-NLC-Sep) as a novel strategy to refine the biopharmaceutical profile PRA, for dermal administration in treatment skin inflammation that may be caused by possible abrasion. This stratagem intends improve joining PRA with skin, improving its retention anti-inflammatory effect. Gels were evaluated various parameters such pH,...
Apremilast (APM) is a novel drug for the treatment of psoriasis and psoriatic arthritis. APM phosphodiesterase 4 (PDE4) inhibitor, raising intracellular cAMP levels thereby decreasing inflammatory response by modulating expression TNF-α, IL-17, IL-23, other cytokines. The goal this study to develop gels as new pharmaceutical formulation topical psoriasis. was solubilized in Transcutol-P incorporated into Pluronic F127, Sepigel, carbomer bases at different proportions. All formulations were...
Abstract Three-dimensional (3D) bioprinting is considered one of the most advanced tools to build up materials for tissue engineering. The aim this work was design, development and characterization a bioink composed human mesenchymal stromal cells (hMSC) extrusion through nozzles create these 3D structures that might potentially be apply replace function damaged natural tissue. In study, we focused on advantages wide potential biocompatible biomaterials, such as hyaluronic acid alginate...
Nanocomposite gels consist of nanoparticles dispersed in a gel matrix. The main aim this work was to develop nanocomposite for topical delivery Flurbiprofen (FB) humans and farm animals. were prepared stemming from (NPs) freeze-dried with two different cryoprotectants, D-(+)-trehalose (NPs-TRE) polyethylene glycol 3350 (NPs-PEG), sterilized by gamma (γ) irradiation, gelled Sepigel® 305. FB-NPs-TRE FB-NPs-PEG physiochemically characterized terms appearance, pH, morphological studies,...
This study explores the incorporation of 10% 3-O-ethyl L-ascorbic acid (ETVC), a derivative vitamin C, into two lipid gel systems: hydrogel (HG) consisting exclusively lipids and water bigel (BG) combining with an oleogel made from olive oil beeswax. We investigated ETVC release profiles both materials using synthetic membranes measured their permeation through porcine skin in vitro. Additionally, interaction these systems stratum corneum (SC) was determined. Results indicate that BG...
Baricitinib, commonly used for autoimmune diseases, is typically administered orally, which can lead to systemic adverse effects. A topical formulation could potentially offer localized therapeutic effects while minimizing these side
Transdermal drug delivery is important to maintain plasma concentrations for therapeutic efficacy. The current study reports the design, formulation, and evaluation of tizanidine transdermal patches formulated using chitosan thiolated chitosan, ethyl cellulose (EC), polyvinylpyrrolidone (PVP), Eudragit RL100 in different ratios. were flaxseed oil coriander 1% v/w, 2% 3% 4% 5% 10% v/w. subjected characterization physicochemical property (thickness, weight uniformity, content, efficiency,...
The low water solubility of baricitinib (BCT) limits the development new formulations for topical delivery drug. aims this study were to assess BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible water, evaluate drug uptake human skin and porcine tissues (sclera, cornea, oral, sublingual, vaginal), subsequently extract from so as determine recovery using vitro techniques. Analytical methods developed validated quantification Transcutol...