A5018913201- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Atherosclerosis and Cardiovascular Diseases
- Prostate Cancer Treatment and Research
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- MicroRNA in disease regulation
- Arsenic contamination and mitigation
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Mycotoxins in Agriculture and Food
- NF-κB Signaling Pathways
- Genetic factors in colorectal cancer
- Prostate Cancer Diagnosis and Treatment
Presidency University
2015-2025
Creative Commons
2022
Institute of Post Graduate Medical Education and Research
2022
La Jolla Institute for Immunology
2018
National Institute of Cholera and Enteric Diseases
2013-2017
Chittaranjan National Cancer Institute
2008-2013
Eli Lilly (United States)
2003
Atherosclerosis is a chronic inflammatory disease that driven by the interplay of pro- and anti-inflammatory leukocytes in aorta. Yet, phenotypic transcriptional diversity aortic poorly understood.We characterized from healthy atherosclerotic mouse aortas in-depth single-cell RNA-sequencing mass cytometry (cytometry time flight) to define an atlas immune cell landscape atherosclerosis.Using chow diet- Western diet-fed Apoe-/- Ldlr-/- mice, we detected 11 principal leukocyte clusters with...
The aim of this study is to understand the mechanism EGFR overexpression in head and neck squamous cell carcinoma (HNSCC). For reason, expression/mutation were analyzed 30 dysplastic lesions 148 HNSCC samples Indian patients along with 3 lines. In addition, deletion/methylation/mutation/expression SH3GL2 (associated degradation) CDC25A dephosphorylation EGFR) same set samples. Our revealed high frequency (66–84%), low gene amplification (10–32.5%) absence functional mutation No correlation...
Background: Exploring the potential of BOLA3-DT as a diagnostic biomarker in prostate cancer. Methods: Expression lncRNA was analyzed between normal and tumor samples GDC TCGA PRAD (Genomic Data Commons: The Cancer Genome Atlas Prostate Adenocarcinoma Collection) dataset. Disease progression-related clinicopathological parameters such serum PSA level (ng/ml) Gleason score were associated with expression using same To validate these findings, checked our sample set 15 PCa (prostate cancer)...
Abstract The aim of our study was to analyze the alterations some candidate tumor suppressor genes (TSGs) viz. LIMD1 , LTF CDC25A SCOTIN RASSF1A and CACNA2D2 located in chromosomal region 3p21.31 associated with development early dysplastic lesions head neck. In analysis 72 116 squamous cell carcinoma neck, both deletion promoter methylation have been seen these except for where no has detected. alteration highest (50%) mild did not change significantly during progression indicating its...
Abstract To understand the association of candidate tumour suppressor genes SH3GL2 , p 16 INK 4 a 14 ARF and 15 b in pathogenesis head neck squamous cell carcinoma (HNSCC), we studied deletion, mutation, methylation these 61 dysplastic lesions 94 HNSCC samples. In mild dysplasia, showed higher frequency overall alterations (60–70%) than (40%). However, subsequent stages progression, alteration did not change significantly. One novel mutation common exon 2 / three 9 were seen. Concordance was...
To understand the association between candidate tumor suppressor genes (TSGs) human mismatch repair protein homologue 1 (hMLH1), AP20 region gene (APRG1), integrin alpha RLC (ITGA9), RB1 serine phosphates from chromosome 3 (RBSP3) at chromosomal 3p22.3 and development of head neck squamous cell carcinoma (HNSCC), alterations (deletion/promoter methylation/expression) these were analyzed in 65 dysplastic lesions 84 HNSCC samples. Clinicopathological correlations made with genes. In HNSCC,...
Apart from other risk factors, chronic inflammation is also associated with the onset of Prostate Cancer (PCa), wherein pathogen infection and tissue microbiome dysbiosis are known to play a major role in both inflammatory response cancer development. However, except for few studies, link between microbes PCa remained poorly understood. To explore potential signature Indian patients, we investigated differential compositions commensal bacteria among patients benign prostatic hyperplasia...
Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence GDM among pregnant women visiting antenatal clinic tertiary-care hospital Kolkata, India; possible mechanism disease pathogenesis potency associated parameters as biomarkers explored.735 screened for according DIPSI (Diabetes in Pregnancy Study Group India) guideline risk-factors analyzed....
India is the home to around 15-20 million asthmatics, and asthma prevalence increasing in Indian metropolitan area, including Kolkata, West Bengal. Complex interactions of genetic environmental factors are involved asthma. Genome-wide search for susceptible loci regulating IgE response (atopy) have identified a candidate gene CD14 which most important context allergic responses respiratory system. This study was aimed investigate role house dust mites development bronchial explore possible...
Abstract Introduction To understand the role of two interacting proteins LIMD1 and pRB in development head neck squamous cell carcinoma (HNSCC), alterations these genes were analyzed 25 dysplastic lesions, 58 primary HNSCC samples lines. Methods Deletions RB1 along with mutation promoter methylation analysis LIMD1. The genotyping linked microsatellite marker, hmlimD1, was done to find out any risk allele. mRNA expression by Q-PCR. Immunohistochemical performed. Alterations correlated...
The protein SLIT2 and its receptor ROBO1 regulate different cellular processes, such as proliferation, apoptosis, migration. In this study our aim is to understand the alterations of these genes during development head neck squamous cell carcinoma (HNSCC).First, molecular were analyzed in 30 dysplastic lesions, 128 primary HNSCC samples, 1 line. Then correlated with mRNA expression (n = 22) 29). Finally, clinicopathologic parameters clinical outcomes patients.ROBO1 had a comparatively high...
The aim of this study was to cast light on initiating molecular events associated with the development premalignant oral lesions induced by tobacco and/or areca nut.Immunohistochemical analyses cell cycle regulatory proteins (LIMD1, RBSP3, p16, RB, phosphorylated p53), EGFR and SH3GL2 (EGFR protein) were performed inflammatory/ ulcerative epithelium adjacent hyperplastic/mild dysplastic lesions.No change in expression seen inflammatory epithelium. Reduced nuclear LIMD1 evident In...
The five different bio-agents viz., Trichoderma viride, T. harzianum, virens, Pseudomonas fluorescens and Bacillus subtilis were evaluated against Pyricularia oryzae at four eight days after incubation through dual culture technique. Among the bio-agents, highest per cent inhibition of mycelial growth fungus was recorded in virens i.e. 67 70 percent respectively with mean 68.5 followed by viride 61 63 62 cent. did not show any P. as pathogen over grew bio-agents.
Present study involved identification of offending out-door aero-allergens and associated genetic pathway in nasso-bronchial asthma among Kolkata population.Skin-prick test was done 950 asthmatic patients against 11 common total serum IgE concentration measured. PCR-RFLP non-asthmatic control (n=220 each) to characterize functional polymorphism, C(-159)T, CD14, a positional candidate gene for allergy. Association polymorphisms made with clinico-pathological conditions.We identified Cocos...
Arsenic is known to be an important aetiological factor for the development of urinary bladder cancer. It found excessively in ground water certain geographical areas, including West Bengal. We have studied patients with recurrent cancer from different areas this Indian state and correlated arsenic as a causative aggressiveness biological behaviour included 31 various parts Bengal who were operated our institute. Their clinical residential data their content tumour tissue measured....
AbstractThe genetic etiology of gestational diabetes mellitus (GDM) was suggested to overlap with type-2 diabetes(T2D). Transcription factor 7-like 2 (TCF7L2) and Proprotein Convertase Subtilisin/Kexin type (PCSK2) are T2D susceptibility genes the insulin synthesis/processing pathway. We analyzed associations TCF7L2 PCSK2 variants GDM risk evaluated their potential impact on impaired processing in an eastern Indian population. The study included 114 (case) 228 non-GDM pregnant women...