A5056084425- Analytical Methods in Pharmaceuticals
- Phagocytosis and Immune Regulation
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Antibiotics Pharmacokinetics and Efficacy
- Mass Spectrometry Techniques and Applications
- Blood Pressure and Hypertension Studies
- Ginseng Biological Effects and Applications
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- NF-κB Signaling Pathways
- bioluminescence and chemiluminescence research
- Erythropoietin and Anemia Treatment
- Phytochemistry and Bioactivity Studies
- Medicinal Plants and Bioactive Compounds
- HER2/EGFR in Cancer Research
- Lipid metabolism and biosynthesis
- Cancer-related Molecular Pathways
- Advancements in Transdermal Drug Delivery
- Multicomponent Synthesis of Heterocycles
Peking Union Medical College Hospital
1998-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2024
Anhui University of Traditional Chinese Medicine
2023-2024
Taiyuan University of Science and Technology
2024
Henan University of Science and Technology
2021
Peking University
2014-2015
Rutgers, The State University of New Jersey
2010
National Institutes of Health
2006
The University of Texas at Austin
2004
University of Southern California
1991
BPI-9016M is a novel small-molecule inhibitor that simultaneously targets both c-Met and AXL tyrosine kinases. This phase I study aimed to determine the maximum tolerated dose (MTD), safety, pharmacokinetics, antitumor activity of in Chinese patients with advanced non-small cell lung cancer (NSCLC).Over range 100 mg 800 mg, eligible were administered single 9016M tablet received 7 days pharmacokinetics evaluation, followed by continuous administration (QD dosing, 28 days). Standard "3 + 3"...
Abstract Background As a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor ( MET ) exhibits high aberrant expression across various tumors. This study aimed to evaluated the safety, tolerability, efficacy and pharmacokinetics (PK) of BPI-9016M, novel kinase inhibitor (TKI) targeting c-MET, in c-MET overexpression or exon 14 skipping mutation patients with locally advanced metastatic non-small-cell lung cancer (NSCLC). Methods/design In this two-part...
Etimicin is a fourth-generation aminoglycoside antibiotic. It has potent activity and low toxicity when employed for the treatment of Gram-negative Gram-positive bacterial infections. The pharmacokinetics etimicin in humans have not been elucidated completely. Two liquid chromatography-tandem mass spectrometry (LC-MS/MS) bioanalytical methods, without use any ion-pairing reagents, were developed validated quantification human samples serum urine. Using deuterated reagent as internal...
Ganoderma lucidum spore powder (GLSP), a high-value health food and medicine, has attracted widespread attention for its biological components abundant pharmacological activities. However, the chemical component classification, fragmentation patterns, fatty acid quantification activities of GLSP against p38 MAPK have not been clearly articulated. In present study, total 142 compounds were identified in by UPLC-Orbitrap-HRMS, including 55 lipids (3 glycerides, 21 phospholipids, 4 glycolipids,...
As the predominant phospholipids in mammalian cells, phosphatidylcholines (PCs) have been demonstrated to play a crucial role multitude of vital biological processes. Research has highlighted significance diversity PC isomers as instigators both physiological and pathological responses, particularly those with variations position double bonds within their fatty chains. Profiling these is paramount advancing our understanding functions. Despite availability analytical methods utilizing...
S05590 is a fixed-dose combination of perindopril tert-butylamine 4 mg/indapamide 1.25 mg, and S06593 arginine 5 mg/amlodipine mg. The purpose this study was to determine whether pharmacokinetic interactions exist among the components S06593, compared with amlodipine as reference drugs, in healthy Chinese male volunteers after single oral administration under fasting conditions. A single-center, open-label, randomized, three-period, six-way crossover conducted. total 42 participants were...