A5074266062- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Pancreatic and Hepatic Oncology Research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- interferon and immune responses
- Adrenal and Paraganglionic Tumors
- Lung Cancer Research Studies
- RNA modifications and cancer
- Genomics and Rare Diseases
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Chemokine receptors and signaling
- Ethics in Clinical Research
Latvian Biomedical Research and Study Centre
2016-2025
University of Latvia
2018-2021
Unidad de Cirugía Artroscópica
2018
Foundation for Ichthyosis and Related Skin Types
2018
Latvia University of Life Sciences and Technologies
2018
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication diabetes have had limited success. In study, new international genomics consortium, JDRF funded Diabetic Nephropathy Collaborative Research Initiative, assembled nearly 20,000 samples from participants with type 1 diabetes, and without disease. The authors found 16 disease–associated loci at genome-wide significance. strongest signal...
Although the host defense mechanisms against SARS-CoV-2 infection are still poorly described, they of central importance in shaping course disease and possible outcome. Metabolomic profiling may complement lacking knowledge molecular underlying clinical manifestations pathogenesis COVID-19.
The Genome Database of the Latvian Population (LGDB) is a national biobank that collects, maintains, and processes health information, data, biospecimens collected from representatives population. These specimens serve as foundation for epidemiological research prophylactic therapeutic purposes.Participant recruitment biomaterial data processing were performed according to specifically designed standard protocols, taking into consideration international quality requirements. Legal ethical...
The study was conducted to investigate the effects of metformin treatment on human gut microbiome's taxonomic and functional profile in Latvian population, evaluate correlation these changes with therapeutic efficacy tolerance.In this longitudinal observational study, stool samples for shotgun metagenomic sequencing-based analysis were collected two cohorts. first cohort included 35 healthy nondiabetic individuals (metformin dose 2x850mg/day) at three time-points during administration....
Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), can manifest as long-term symptoms in multiple organ systems, including respiratory, cardiovascular, neurological, and metabolic systems. In patients with severe COVID-19, immune dysregulation is significant, the relationship between regulation response great interest determining pathophysiological mechanisms. We aimed to characterize metabolomic footprint recovering COVID-19 at three consecutive timepoints compare metabolite...
Long-COVID affects at least 10% of COVID-19 survivors, displaying debilitating symptoms across multiple organ systems. Despite the increasing prevalence, underlying causes remain unclear. This study presents a unique analysis PBMC transcriptomic landscape and patients single-cell resolution. We reconstructed cell state communication using differentially expressed gene profiling ligand-receptor interaction analyses. Our results reveal altered T NK subset proportions, diminished proliferating...
Pituitary cells are specialized located within the pituitary gland, a small, pea-sized gland situated at base of brain. Through use cellular electrophysiological techniques, electrical properties these have been progressively revealed. This review paper aims to introduce ion currents that known be functionally expressed in cells. These include voltage-gated Na+ current (INa), erg-mediated K+ (IK(erg)), M-type (IK(M)), hyperpolarization-activated cation (Ih), and large-conductance...
Diabetes leads to reduced nitric oxide bioavailability, resulting in endothelial dysfunction. However, overproduction of due hyperglycaemia is associated with oxidative stress and tissue damage. The objective this study was characterise production (NO) added nitrite nitrate (NO2‑+NO3‑) concentration the blood urine patients without diabetic nephropathy. A total 268 type 1 diabetes 69 healthy subjects were included. Diabetic nephropathy defined as macroalbuminuria and/or estimated glomerular...
Abstract Background Type 2 diabetes complications cause a serious emotional and economical burden to patients healthcare systems globally. Management of both acute chronic diabetes, which dramatically impair the quality patients' life, is still an unsolved issue in care, suggesting need for early identification individuals with high risk developing complications. Methods We performed genome-wide association study 601 type after stratifying them according presence or absence four types...
Abstract Background Public awareness and engagement are among the main prerequisites for protecting rights of research participants successful sustainable functioning biobanks. The aim our study was to analyse public attitudes towards biobanks in Latvia, compare these data with results 2010 Eurobarometer study. We also analysed influence on willingness participate biobank studies preferred type informed consent. Methods developed a 12-question survey repeating seven questions about from...
Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite wide application in of multiple health conditions, glycemic response metformin highly variable, emphasizing need reliable biomarkers. We chose RNA-Seq-based comparative transcriptomics approach evaluate systemic effect and highlight potential predictive biomarkers drug-naïve volunteers with vivo. The longitudinal blood-derived transcriptome analysis revealed...
As the need for effective antiviral treatment intensifies, such as with coronavirus disease 19 (COVID-19) infection, it is crucial to understand that while mechanisms of action these drugs or compounds seem apparent, they might also interact unexplored targets, cell membrane ion channels in diverse types. In this review paper, we demonstrate many different compounds, addition their known interference viral infections, may directly influence various types ionic currents on surface host cell....
Metformin is a commonly used antihyperglycaemic agent for the treatment of type 2 diabetes mellitus. Nevertheless, exact mechanisms action, underlying various therapeutic effects metformin, remain elusive. The goal this study was to evaluate alterations in longitudinal whole-blood transcriptome profiles healthy individuals after one-week metformin intervention order identify novel molecular targets and further prompt discovery predictive biomarkers response. Next generation sequencing-based...
Abstract Microvascular free flap surgery, has become an important part of reconstructive surgery during the last decades, as it allows closure various tissue defects and recovery organs function. Despite surgical progress resulting in high rates transferred survival, risk pedicle vessels thrombosis still remains a significant problem. A total 108 articles from Pubmed Science Direct databases published 2005–2015 were analysed. This review literature assessed influence patient-dependent...