A5038567891- Metabolism, Diabetes, and Cancer
- Retinal Diseases and Treatments
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Nitric Oxide and Endothelin Effects
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Pituitary Gland Disorders and Treatments
- Retinal Imaging and Analysis
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Ubiquitin and proteasome pathways
- Neuroendocrine Tumor Research Advances
- Chronic Kidney Disease and Diabetes
- Neurological Disease Mechanisms and Treatments
- Digestive system and related health
- Renal Diseases and Glomerulopathies
- Cardiovascular and exercise physiology
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Cardiac Health and Mental Health
- Pain Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Diet and metabolism studies
University of Latvia
2014-2024
Pauls Stradiņš Clinical University Hospital
2017-2018
Latvijas Organiskās Sintēzes Institūts
2009-2016
Institute of Organic Synthesis
2011-2012
Significance Statement Although studies show that diabetic kidney disease has a heritable component, searches for the genetic determinants of this complication diabetes have had limited success. In study, new international genomics consortium, JDRF funded Diabetic Nephropathy Collaborative Research Initiative, assembled nearly 20,000 samples from participants with type 1 diabetes, and without disease. The authors found 16 disease–associated loci at genome-wide significance. strongest signal...
Abstract Background and Aim Little is known about the diagnostic value of hepatic steatosis index (HSI) fatty liver (FLI), as well their link to metabolic syndrome in type 1 diabetes mellitus. We have screened effectiveness FLI HSI an observational pilot study 40 patients with diabetes. Methods were calculated for 201 Forty FLI/HSI values corresponding different risk invited magnetic resonance study. In‐phase/opposed‐phase technique was used. Accuracy indices assessed from area under...
The study was conducted to investigate the effects of metformin treatment on human gut microbiome's taxonomic and functional profile in Latvian population, evaluate correlation these changes with therapeutic efficacy tolerance.In this longitudinal observational study, stool samples for shotgun metagenomic sequencing-based analysis were collected two cohorts. first cohort included 35 healthy nondiabetic individuals (metformin dose 2x850mg/day) at three time-points during administration....
Context: Metformin improves hyperglycaemia via mechanisms which include activation of AMP-activated protein kinase (AMPK). Recent findings indicate that some metabolic actions metformin occur also by AMPK-independent mechanisms.Objective: To study the action on expression GLUT1 glucose transporter in rat streptozotocin model diabetes mellitus.Materials and methods: Streptozotocin-induced rats were treated with while monitoring parameters carbohydrate lipid metabolism. mRNA kidneys, heart,...
Diabetes leads to reduced nitric oxide bioavailability, resulting in endothelial dysfunction. However, overproduction of due hyperglycaemia is associated with oxidative stress and tissue damage. The objective this study was characterise production (NO) added nitrite nitrate (NO2‑+NO3‑) concentration the blood urine patients without diabetic nephropathy. A total 268 type 1 diabetes 69 healthy subjects were included. Diabetic nephropathy defined as macroalbuminuria and/or estimated glomerular...
Abstract Background Type 2 diabetes complications cause a serious emotional and economical burden to patients healthcare systems globally. Management of both acute chronic diabetes, which dramatically impair the quality patients' life, is still an unsolved issue in care, suggesting need for early identification individuals with high risk developing complications. Methods We performed genome-wide association study 601 type after stratifying them according presence or absence four types...
Background and Objective. Glucose transport via GLUT1 protein could be one of additional mechanisms the antidiabetic action sulfonylureas. Here, gene expression was studied in rats course severe mild streptozotocin-induced diabetes mellitus under glibenclamide treatment. Material Methods. Severe induced using different streptozotocin doses standard or high fat chow. Rats were treated with (2 mg/kg daily, per os for 6 weeks). The therapeutic effect monitored by measuring several metabolic...
Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite wide application in of multiple health conditions, glycemic response metformin highly variable, emphasizing need reliable biomarkers. We chose RNA-Seq-based comparative transcriptomics approach evaluate systemic effect and highlight potential predictive biomarkers drug-naïve volunteers with vivo. The longitudinal blood-derived transcriptome analysis revealed...
Insulin pump therapy represents an alternative to multiple daily injections and can improve glycemic control quality of life (QoL) in Type 1 diabetes mellitus (T1DM) patients. We aimed explore the differences factors related T1DM-specific QoL such patients Latvia.A mixed-method cross-sectional study on 87 adult T1DM included 20 users 67 who participated quantitative part study; 8 13 injection qualitative part. Patients were invited participate using a dedicated digital platform. Their...
Abstract Background Diabetic retinopathy (DR) is the leading cause of adult blindness in working age population worldwide, which can be prevented by early detection. Regular eye examinations are recommended and crucial for detecting sight-threatening DR. Use artificial intelligence (AI) to lessen burden on healthcare system needed. Purpose To perform a pilot cost-analysis study DR cohort minority women with DM Oslo, Norway, that have highest prevalence diabetes mellitus (DM) country, using...
Anti-ischaemic drug mildronate suppresses fatty acid metabolism and increases glucose utilization in myocardium. It was proposed that it could produce a favourable effect on metabolic parameters transport diabetic animals. Rats with streptozotocin diabetes mellitus were treated (100 mg/kg daily, per os, 6 weeks). Therapeutic of monitored by measuring animal weight, concentrations blood glucose, insulin, triglycerides, free acids, ketone bodies cholesterol, glycated haemoglobin cent (HbA1c%)...
In diabetes mellitus (DM), both hyperglycaemia and hyperlipidaemia can initiate accumulation of fat in the liver, which might be further mediated by inducible nitric oxide synthase. We have studied changes GLUT1, (NO · ) concentration liver damage two rat DM models. STZ model was induced strepozotocin 50 mg/kg. HS high‐fat diet 30 mg/kg streptozotocin. GLUT1 expression means real‐time RT‐PCR immunohistochemistry. Production NO monitored erythrocyte sedimentation rate spectroscopy Fe‐DETC‐NO...
Development of complications diabetes mellitus (DM), including diabetic nephropathy, is a complex multi-stage process, dependent on many factors the modification nitric oxide (NO) production and an impaired DNA repair. The goal this work was to study in vivo effects 1,4-dihydropyridine AV-153, known as antimutagen binder, expression several genes proteins involved NO metabolism repair kidneys rats with streptozotocin (STZ)-induced model DM. Transcription intensity monitored by means...
In this study, a novel method for automatic microaneurysm detection in color fundus images is presented. The proposed based on three main steps: (1) image breakdown to smaller patches, (2) inference segmentation models, and (3) reconstruction of the predicted map from output patches. an ensemble individual deep networks, such as U-Net, ResNet34-UNet UNet++. performance evaluation calculation Dice score IoU values. ensemble-based model achieved higher (0.95) (0.91) values compared other...
Diabetes mellitus (DM) and its complications cause numerous health social problems throughout the world. Pathogenic actions of nitric oxide (NO) are responsible to a large extent for development DM. Search compounds regulating NO production in patients with DM is thus important pharmacological drugs. Dihydropyridines (1,4-DHPs) prospective from this point view. The goals study were vivo effects new DHPs on reactive nitrogen oxygen species streptozotocin (STZ)-induced model rats their ability...
Impaired degradation of proteins by the ubiquitin-proteasome system (UPS) is observed in numerous pathologies including diabetes mellitus (DM) and its complications. Dysregulation proteasomal might be because altered expression genes involved UPS. The search for novel compounds able to normalize UPS appears a topical problem. A group 1,4-dihydropyridine (1,4-DHP) derivatives lacking Ca2+-antagonists activities, but capable produce antidiabetic, antioxidant DNA repair enhancing effects, were...
Interval walking training has demonstrated more pronounced positive effects on physical fitness and metabolism in type 2 diabetes (T2D), compared to continuous walking. One of the pathogenic mechanisms T2D is associated with derangements leptin/adiponectin axis, which might predispose affected individuals vascular inflammation albuminuria. The aim this study was investigate interval delivered through smart mobile devices upon albuminuria ratio patients T2D.Patients aged 35-75 were randomized...
Abstract Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect. Growth hormone overproducing GH-producing PitNETs acromegaly leading connective tissue, metabolic oncologic disorders. The medical treatment is somatostatin analogues (SSA) in specific cases combined with dopamine agonists (DA), but almost half patients display partial full SSA resistance and potential causes this unknown. In study we...
Streptozotocin (STZ) was used to induce the diabetic rat model. STZ rats were treated with mildronate (100 mg/kg daily, per os or intraperitoneally for 6 weeks). Body weight, blood glucose, triglyceride, ketone body concentrations, glycated hemoglobin percent (HbA1c%), glucose tolerance, and development of neuropathic pain monitored throughout experiment. In + group, treatment caused a significant decrease in mean (on week 4) triglyceride concentrations weeks 3-6), significantly slowed...
Abstract Background Serum angiopoietin 2 levels have been associated with endothelial dysfunction and diabetic kidney disease. Derangements in autonomous nervous system lead to increased production of vasoconstrictory angiogenic mediators such as norepinephrine neuropeptide Y are risk microvascular complications. Aim To investigate associations between 2, disease patients type 1 diabetes mellitus. Methods 289 mellitus duration > year were included. Patients stratified according presence...