A5018465826- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Garlic and Onion Studies
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Respiratory viral infections research
- Lipid metabolism and biosynthesis
- Mosquito-borne diseases and control
- Animal health and immunology
- Gout, Hyperuricemia, Uric Acid
- RNA regulation and disease
- Insect Resistance and Genetics
- Liver Disease Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Stress Responses and Cortisol
- Human Health and Disease
- Plant Pathogenic Bacteria Studies
- Vector-Borne Animal Diseases
- Advanced Thermodynamic Systems and Engines
- Aquaculture Nutrition and Growth
- Contemporary Christian Leadership and Education
University of Nebraska–Lincoln
2025
University of Kentucky
2023-2024
Karachi Medical and Dental College
2018-2024
Chonnam National University
2021-2022
Nishtar Medical College and Hospital
2022
University of Agriculture Faisalabad
2017-2021
University of Faisalabad
2017-2021
The University of Agriculture, Peshawar
2018-2019
University of Veterinary and Animal Sciences
2019
University of Karachi
2012
Humans and equines are two dead-end hosts of the mosquito-borne West Nile virus (WNV) with similar susceptibility pathogenesis. Since introduction WNV vaccines into equine populations United States America (USA) in late 2002, there have been only sporadic cases infection equines. These generally attributed to unvaccinated under-vaccinated In contrast, due lack a human vaccine, humans remained steadily high. An average 115 deaths reported per year USA since first case 1999. Therefore,...
ABSTRACT Influenza D virus (IDV) utilizes bovines as a primary reservoir with periodical spillover to other hosts. We have previously demonstrated that IDV binds both 9- O -acetylated N -acetylneuraminic acid (Neu5,9Ac 2 ) and -glycolylneuraminic (Neu5Gc9Ac). Bovines produce Neu5,9Ac Neu5Gc9Ac, while humans are genetically unable synthesize Neu5Gc9Ac. -Acetylation of sialic acids is catalyzed by CASD1 via covalent acetyl-enzyme intermediate. To characterize the role Neu5Gc9Ac in infection...
The foreign antigen that enters into the body is detected by immune system through presenting cells leading to production of antibodies. use anti-idiotype antibodies a new way excite response identifies and eliminates antigens entered body. These Anti-idiotype have ability decrease non-specific binding antigenic protein epitopes because high specificity for determinants. attach paratope idiotype antibody stimulate precise reaction same as external antigen. are peerless therapeutic candidate...
Tight junctions (TJs) are a major barrier and also an important portal of entry for different pathogens. Porcine sapovirus (PSaV) induces early disruption the TJ integrity polarized LLC-PK cells, allowing it to bind buried occludin co-receptors hidden beneath TJs on basolateral surface. However, signaling pathways involved in PSaV-induced dissociation not yet known. Here, we found that RhoA/ROCK/MLC pathway was activated cells during infection PSaV Cowden strain presence bile acid. Specific...
Abstract The human body harbors trillions of microbes collectively known as microbiota. gut microbiota is importantly involved in most the metabolic and regulatory pathways. needs to be balanced for health host. Several factors are distribution body, cases these microbiotas commensals, but some circumstances lead serious disorders development infections from When parasites colonize gut, balance between host can disturbed. Parasitic invasion associated with unhygienic conditions including...
Influenza C virus (ICV) is increasingly associated with community-acquired pneumonia (CAP) in children and its disease severity worse than the influenza B virus, but similar to A CAP. Despite ubiquitous infection landscape of ICV humans, little known about replication pathobiology animals. The goal this study was understand kinetics, tissue tropism, pathogenesis human (huICV) comparison swine D (swIDV) guinea pigs. Intranasal inoculation both viruses did not cause clinical signs, however,...
The present study aimed to evaluate the immunopotentiating effect of plant-derived soyasaponin and its immunogenicity in chickens challenged with Newcastle disease virus (NDV). Soyasaponin was extracted from soybean seeds detected using phytochemical tests, followed by quantification through dry-weight method. One-day-old broiler chicks (n = 90) were divided into 3 groups, named as A, B, C. Group A birds orally administrated (5 mg/kg), immunization inactivated ND vaccine intramuscularly...
The immunoprophylactic potential of anti-idiotype (anti-id) foot-and-mouth disease (FMD) antigen (Ag) was evaluated in the calves. idiotype antibodies (Ab1) were produced experimental goats by injecting inactivated FMD virus. Fab (fragment binding) Ab1 injected into layer birds to raise anti-id (Ab2). Ab2 purified from egg yolks. component emulsified Montanide (1:1) and used as a surrogate immune response adjuvanted monovalent trivalent virus determined mice. comparative potentiation...
The use of antibodies in the biopharmaceuticals has been increased from therapeutic to prevention through vaccination.However, purification processes adopted by industries make them expensive use.Ammonium sulfate precipitation is an old and easy way purify serum egg yolks.The purity somewhat compromised with ammonium precipitation, therefore, a combination chromatographic techniques adopted.Presently, alone Octanoic acid was used for caprine yolk.The results purified terms their yield were...
Species A rotavirus (RVA) is one of the pathogens causing severe acute gastroenteritis in young children and animals worldwide. RVA replicates assembles its immature particle within electron dense compartments known as viroplasm. Despite importance lipid droplet (LD) formation viroplasm, upstream molecules modulating LD have remained elusive. Here, we demonstrate that infection reprogrammes sterol regulatory element binding proteins (SREBPs)-dependent lipogenic pathways virus-infected cells....
Equine rotavirus species A (ERVA) G3P[12] and G14P[12] are two dominant genotypes that cause foal diarrhoea with a significant economic impact on the global equine industry. ERVA can also serve as source of novel (equine-like) (RVA) reassortants zoonotic potential those identified previously in 2013-2019 when G3-like RVA was responsible for worldwide outbreaks severe gastroenteritis hospitalizations children. One hurdle to research is standard cell culture system optimized human replication...
Background: Restless Legs Syndrome (RLS) is a chronic neurological disorder characterized by uncomfortable sensations and an irresistible urge to move the legs, particularly during rest. The prevalence of RLS in Pakistan, especially among students, remains underexplored.Objective: This study aimed determine associated factors information technology students Mirpurkhas, Sindh.Methods: A cross-sectional was conducted from July 21 August 4, involving 200 IT (115 males, 85 females) aged 18-28...
Biomarker research and justification for neurodegenerative illnesses have seen enormous efforts over the last ten years. Bio-fluid-based biomarkers been believed to provide a better easier approach detecting diagnosing nervous system pathologies. Objectives: To evaluate diagnostic potential of certain in serum cerebrospinal fluid diagnose Alzheimer’s disease, Parkinson’s Huntington’s disease at an initial stage. Methods: 280 participants were taken distributed into four groups, comprising,...
BDNF was a protein that has crucial role in development of brain fetuses however its levels were affected by maternal stress response cause complications. Objective: To study the effects Brain Derived Neurotrophic Factor (BDNF) during pregnancy on developing fetus order to bring clinicopathological correlations. Methods: As PRISMA guidelines suggested, an extensive database search made from PubMed, Science Direct, and Google Scholar for articles released between 2016 2024. Included studies...
The burden of life on the earth is source biological contamination in water. Nanotechnology has promising contributions control microbial contaminations and medicinal plants further increase these properties. Presently, copper acetate nickel oxide nanoparticles were synthesized using 1mM solution each with Ziziphus mauritiana leaves extract as reducing agent. Nanoparticles characterized through UV vis-spectroscopy scanning electron microscope antimicrobial properties determined disc...
have different endpoint criteria i.e.DNA damage, chromosomal aberrations, and mutations.These assays are widely employed in detecting carcinogenicity because of an association between genotoxicity cancer, also the for assessment assay is not as sensitive Abstract Purpose: Allium sativum, Trachyspermum, Zingiber officinale plants used spices edible foods.Although some these Ethnomedicine well, their excessive use may result DNA damage mutation that come out form cancer.This study was aimed at...
Mosquito-borne diseases can be reduced drastically with the aid of vaccines which provoke mosquitocidal or mosquito-killing effect.The midgut mosquito performs a fundamental role in development and transmission ailment.Anti-midgut antibodies show extensive variety activity, blockading pathogen various species mosquitoes.In addition to reducing egg-laying ability mosquitoes survivorship also block activity pathogen.Mitsuhashi Maramorosch media was used culture cells.The cells were formalin...