Shutong Chen

ORCID: 0000-0001-9406-6454
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Research Areas
  • Aquatic Ecosystems and Phytoplankton Dynamics
  • Species Distribution and Climate Change
  • Advanced Photocatalysis Techniques
  • Gas Sensing Nanomaterials and Sensors
  • Histone Deacetylase Inhibitors Research
  • Phosphorus and nutrient management
  • Animal and Plant Science Education
  • Echinoderm biology and ecology
  • Plant and animal studies
  • Seaweed-derived Bioactive Compounds
  • Polysaccharides and Plant Cell Walls
  • Cancer-related Molecular Pathways
  • Angiogenesis and VEGF in Cancer
  • Phagocytosis and Immune Regulation
  • Gut microbiota and health
  • Long-Term Effects of COVID-19
  • Soil and Water Nutrient Dynamics
  • Plant Growth Enhancement Techniques
  • Groundwater and Isotope Geochemistry
  • Sphingolipid Metabolism and Signaling
  • Environmental remediation with nanomaterials
  • Silymarin and Mushroom Poisoning
  • Covalent Organic Framework Applications
  • Advanced Nanomaterials in Catalysis
  • TiO2 Photocatalysis and Solar Cells

Tobacco Research Institute
2025

Chinese Academy of Agricultural Sciences
2025

Xiamen University
2025

Anhui University of Traditional Chinese Medicine
2024

China Pharmaceutical University
2023

Shantou University
2023

Guangdong Ocean University
2022-2023

Shandong Agricultural University
2022-2023

Suzhou University of Science and Technology
2018-2021

Jiangsu University
2019

Morchella esculenta is an edible mushroom with special flavor and high nutritional value for humans, primarily owing to its polysaccharide constituents. M. polysaccharides (MEPs) possess remarkable pharmaceutical properties, including antioxidant, anti-inflammatory, immunomodulatory, anti-atherogenic activities. The aim of this study was evaluate the in vitro vivo antioxidant potential MEPs. In activity determined using free radical scavenging assays, whereas evaluated through dextran sodium...

10.3390/foods12051115 article EN cc-by Foods 2023-03-06

Nicotiana alata Link et Otto, widely used in landscaping, is not only of great ornamental value but also high commercial and medical value. The global potential habitat N. the environmental factors affecting its distribution are that clear at present. To provide a reference for reasonable extensive planting now future, MaxEnt model was to predict suitable habitats under current future climate conditions, respectively, based on geographic data world bioclimatic variables. results showed mean...

10.1038/s41598-023-29678-7 article EN cc-by Scientific Reports 2023-03-24

Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, fucoidan (SHF) was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with molecular weight of 1166.48 kDa (44.06%, w/w), consisted glucose (32.68%, galactose (24.81%, fucose (20.75%, xylose (6.98%, mannose (2.76%, other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, mannuronic (1.76%, guronuronic w/w). SHF...

10.3390/md21010018 article EN cc-by Marine Drugs 2022-12-26

A preliminary study was conducted of the chemical, structural properties and immunomodulatory activities fucoidan isolated from Sargassum Zhangii (SZ). (SZF) determined to have a sulfate content 19.74 ± 0.01% (w/w) an average molecular weight 111.28 kDa. SZF possessed backbone structure (1,4)-α-d-linked-galactose, (3,4)-α-l-fucose, (1,3)-α-d-linked-xylose, β-d-linked-mannose terminal (1,4)-α-d-linked-glucose. The main monosaccharide composition as 36.10% galactose, 20.13% fucose, 8.86%...

10.1016/j.fochx.2023.100712 article EN cc-by-nc-nd Food Chemistry X 2023-05-16

Colorectal cancer (CRC) is one of the most common cancers worldwide. Nowadays, owing to complex mechanism tumorigenesis, simultaneous inhibition multiple targets an important anticancer strategy. Recent studies have demonstrated receptor tyrosine kinase AXL (AXL) and histone deacetylase 2 (HDAC2) are closely associated with colorectal cancer. Herein, we identified five hit compounds concurrently targeting HDAC2 using virtual screening. Inhibitory experiments revealed these potently inhibited...

10.1080/14756366.2023.2295241 article EN cc-by-nc Journal of Enzyme Inhibition and Medicinal Chemistry 2023-12-22

Dual inhibition of tubulin and neuropilin-1 (NRP1) may become an effective method for cancer treatment by simultaneously killing tumor cells inhibiting angiogenesis. Herein, we identified dual tubulin/NRP1-targeting inhibitor TN-2, which exhibited good inhibitory activity against both polymerization (IC50 = 0.71 ± 0.03 μM) NRP1 0.85 0.04 μM). Importantly, it significantly inhibited the viability several human prostate cell lines. Further mechanism studies indicated that TN-2 could inhibit...

10.1021/acs.jmedchem.3c01572 article EN Journal of Medicinal Chemistry 2023-11-24

The study investigated the effect of Compound Shougong Powder(CSGP) on biological functions triple-negative breast cancer(TNBC) cells and whether its mechanism action was related to epithelial-mesenchymal transition(EMT) signaling pathway. TNBC cells(MDA-MB-231 BT-549) were treated with different concentrations CSGP-containing serum. MTS assay used detect CSGP proliferation cells. EdU staining Flow cytometry examine impact apoptosis Wound-healing Transwell assays evaluate effects migration...

10.19540/j.cnki.cjcmm.20240412.705 article EN PubMed 2024-07-01

Cancer is one of the important factors threatening human health. Hence, it essential to create novel potent drugs treat it. Due strong correlation among histone deacetylase1 (HDAC1), speckle-type POZ protein (SPOP) and cancers, dual inhibition HDAC1 SPOP may be a promising strategy for cancer treatment. In this study, we successfully identified four potential dual-targeting HDAC1/SPOP candidate compounds with structure-based virtual screening. vitro experiments confirmed that had inhibitory...

10.3389/fphar.2023.1208740 article EN cc-by Frontiers in Pharmacology 2023-07-10

Adding biochar from harvested reed to sediments is a new method control the release of sedimentary phosphorus. Three types Mg-modified biochars were prepared by pyrolysis modified magnesium chloride at 300, 450, and 600℃.The phosphate adsorption characteristics three analyzed isothermal experiments. Biochar MBC-450 with good effects was selected as material for following Taking sediment overlying water campus river experimental object, we studied in phosphorus under different dosage modes...

10.13227/j.hjkx.201910010 article EN PubMed 2020-04-08

Abstract Nicotiana alata Link et Otto, widely used in landscaping, is not only of great ornamental value but also high commercial and medical value. The global potential habitat N. the environmental factors affecting its distribution are that clear at present. To provide a reference for reasonable extensive planting now future, MaxEnt model was to predict suitable habitats under current future climate conditions, respectively, based on geographic data world bioclimatic variables. results...

10.21203/rs.3.rs-2258752/v1 preprint EN cc-by Research Square (Research Square) 2022-11-21
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