A5017265114- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Neurological Complications and Syndromes
- Biosimilars and Bioanalytical Methods
- Anesthesia and Sedative Agents
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Clinical Nutrition and Gastroenterology
- Immune Cell Function and Interaction
- Dysphagia Assessment and Management
- Family and Patient Care in Intensive Care Units
- Pneumothorax, Barotrauma, Emphysema
- Clinical Reasoning and Diagnostic Skills
- Myasthenia Gravis and Thymoma
- COVID-19 and healthcare impacts
- Cerebrovascular and Carotid Artery Diseases
Ludwig-Maximilians-Universität München
2017-2024
LMU Klinikum
2018-2024
Friedrich Baur Stiftung
2024
Klinik und Poliklinik für Neurologie
2020-2023
München Klinik
2018-2019
Center for Integrated Protein Science Munich
2019
German Center for Lung Research
2019
Greenslopes Private Hospital
2018
Background: Social networking sites, in particular Facebook, are not only predominant students' social life but to varying degrees interwoven with the medical curriculum. Particularly, Facebook groups have been identified for their potential higher education. However, there is a paucity of data on user types, content, and dynamics study-related groups. Objective: The aim this study was identify role group use, characterize students that use or avoid using (demographics, participation...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) profoundly impacts hemostasis and microvasculature. In the light of dilemma between thromboembolic hemorrhagic complications, in present paper, we systematically investigate prevalence, mortality, radiological subtypes, clinical characteristics intracranial hemorrhage (ICH) disease (COVID-19) patients.
Genetically engineered T cells are powerful anticancer treatments but limited by safety and specificity issues. We herein describe an MHC-unrestricted modular platform combining autologous cells, transduced with a targetable synthetic agonistic receptor (SAR), bispecific antibodies (BiAb) that specifically recruit activate for tumor killing.BiAbs of different formats were generated recombinant expression. retrovirally SARs. T-cell activation, proliferation, differentiation, T-cell-induced...
Neurologic manifestations are increasingly reported in patients with coronavirus disease 2019 (COVID-19). Yet, data on prevalence, predictors and relevance for outcome of neurological requiring intensive care scarce. We aimed to characterize risk factors impact neurologic critically ill COVID-19 patients.
Temporalis muscle (TM) atrophy has emerged as a potential biomarker for wasting. However, its diagnostic utility monitoring tool in intensive care remains uncertain. Hence, the objective of this study was to evaluate value sequential ultrasound- and computed tomography (CT)-based measurements TM thickness (TMT). With prospective observational design, we included 40 patients without preexisting sarcopenia admitted neurointensive unit. TMT measurements, performed upon admission serially every...
Abstract Background Although the relevance of neurointensive medicine and high-quality training corresponding physicians is increasingly recognized, there high heterogeneity in nature, duration, quality care curricula around world. Thus, we aimed to identify, define, establish validity evidence for entrustable professional activities (EPAs) postgraduate determine trainees’ readiness being on-call. Methods After defining EPAs through an iterative process by expert group, used a modified...
Introduction Aneurysmal subarachnoid hemorrhage (aSAH) often necessitates prolonged sedation to manage elevated intracranial pressure (ICP) and prevent secondary brain injury. Optimal timing biomarkers for predicting adverse events (AEs) during interruption of (IS) after are not well established. To guide management in aSAH, we aimed explore the frequency, risk factors, outcomes IS aSAH. Methods In a retrospective cohort study, total 148 patients with aSAH from January 2015 April 2020 were...
In subarachnoid hemorrhage (SAH), titrating sedation to find a balance between wakefulness with the ability perform valid clinical examinations on one hand, and deep minimize secondary brain damage, other is challenging. However, data this topic are scarce, current guidelines do not provide recommendations for protocols in SAH. We designed web-based, cross-sectional survey German-speaking neurointensivists map standards indication monitoring of sedation, duration prolonged biomarkers...
Super-refractory status epilepticus (SRSE) is an enduring or recurring SE after 24 h more of general anesthesia. This study aimed to evaluate the efficacy and safety phenobarbital (PB) for treatment SRSE.This retrospective, multicenter included neurointensive care unit (NICU) patients with SRSE treated PB between September 2015 2020 from six participating centers Initiative German NeuroIntensive Trial Engagement (IGNITE) SRSE. The primary outcome measure was seizure termination. In addition,...
Medical nutritional therapy (MNT) in neurointensive care units (NICUs) is both particularly relevant and challenging due to prolonged analgosedation, immobilization, disorders of consciousness, the high prevalence dysphagia. Moreover, current guideline recommendations predominantly address general intensive unit (ICU) population, overlooking specific characteristics neurological patients. We, therefore, conducted a web-based, cross-sectional survey for German-speaking neurointensivists...
Akinetic mutism is a severe state of impaired volition that can result from stroke. Its therapeutic evidence relies on single case reports used atomoxetine or levodopa with variable latency and efficacy.
Abstract Background Physical inactivity and subsequent muscle atrophy are highly prevalent in neurocritical care recognized as key mechanisms underlying intensive unit acquired weakness (ICUAW). The lack of quantifiable biomarkers for complicates the assessment its relative importance compared to other conditions under syndromic diagnosis ICUAW. We hypothesize that active movement, opposed passive movement without patient participation, can serve a valid proxy activity may help predict...
<p>Supplementary figure legend</p>
<p>Supplementary Figure 4: Human SAR T cells are specifically stimulated by anti-human mesothelin x anti-EGFRv3 2 + 1 BiAb and redirect lysis to mesothelin+ target in vitro vivo</p>
<p>Supplementary Figure 5: Effect of pre-activated SAR T cells on hepatocellular carcinoma and glioblastoma cells
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<p>Supplementary Figure 1: Murine SAR expression and immunophenotyping of transduced T cells</p>
<p>Supplementary Figure 3: In contrast to SAR T cells, CAR cells rely on the release of perforin for efficient killing.</p>