Influenza is an infectious disease caused by the influenza virus, and each year many people suffer from this disease. Hemagglutinin (HA) in membrane of type A viruses recognizes sialylglycoconjugate receptors on host cell surface at initial step infection process; consequently, HA inhibitors are considered potential candidates for antiviral drugs. We identified peptides that bind to receptor-binding sites through a multiple serial selection phage-displayed random peptide libraries. Using H1...

A new species of the stenopodidean shrimp genus Odontozona Holthuis, 1946 is described and illustrated on basis 3 specimens recently collected from submarine caves Okinawa-jima Ie-jima Islands, Ryukyu southwestern Japan, Indo-West Pacific. okunoi sp. nov. closely resembles O. anaphorae Manning Chace, 1990 Ascension Island, South Atlantic Ocean, but differs it by a combination morphological characters, including large cardiac spine carapace, spines pleural surface, posterior tooth telson,...

The aim of the present study was to compare power single nucleotide polymorphism (SNP)-based genome-wide association (GWAS) and haplotype-based GWAS for quantitative trait loci (QTL) detection, detect novel candidate genes affecting economically important traits in a purebred Duroc population comprising seven-generation pedigree. First, we performed simulation analysis using real genotype data this (based on null hypothesis) two methods. We then both methods phenotype 52 traits, which...

Abstract Background Mental health problems during pregnancy are multifaceted major issues. Aim To develop and validate a short screening questionnaire that covers important domains including antenatal depression, tokophobia, fetal bonding disorder, suicidality, emesis. Methods A total of 321 pregnant women who were less than 36 weeks gestation responded to cross‐sectional web survey filled in the 33‐item Dimensional Assessment Mother Baby Organization Questionnaire (DAMBO Q33, available as...

The North Pacific Transition Zone (NPTZ) is known as a global marine hotspot for many endangered and commercially significant highly mobile species. In the last few decades, region has undergone unprecedented physical biological transformations in response to climate variability change. Although it anticipated that species will need adapt shift their distributions, current predictions have relied on short-term data sets or modeled simulations. This left critical gap our understanding of...

Until recently, scientists had no idea how loggerhead sea turtles (Caretta caretta) migrate from their nesting beaches in Japan to nursery grounds Baja California, Mexico. The Thermal Corridor Hypothesis (TCH, Briscoe et al. 2021) combined 16 years of satellite-tracked movement data propose an intermittent thermal corridor that allows juvenile loggerheads transition the Central North Pacific (CNP) west coast America. TCH proposes this migratory opens during anomalously warm conditions and...

Dendritic cells (DCs) loaded with tumour antigens have been successfully used to induce protective immunity in murine models and human trials. However, it is still unclear which DC administration route elicits a superior therapeutic effect. Herein, we investigated the vaccine efficiency of DC2.4 cells, dendritic cell line, pulsed ovalbumin (OVA) E.G7-OVA model after immunization via various routes. After single vaccination using 1 × 106 OVA-pulsed was completely rejected intradermally (i.d.;...

Highly migratory marine species can travel long distances and across entire ocean basins to reach foraging breeding grounds, yet gaps persist in our knowledge of oceanic dispersal habitat use. This is especially true for sea turtles, whose complex life history lengthy pelagic stage present unique conservation challenges. Few studies have explored how these young at-sea turtles navigate their environment, but advancements satellite technology numerical models shown that active passive...

Abstract Background Excess fat deposition could induce phenotypic changes of perivascular adipose tissue (PVAT remodeling), which may promote the progression atherosclerosis via modulation adipocytokine secretion. However, it remains unclear whether and how suppression PVAT remodeling attenuate vascular injury. In this study, we examined effect sodium-glucose cotransporter 2 (SGLT2) inhibitor, luseogliflozin on neointima formation after wire injury in mice. Methods Wilt-type mice fed with...

The eggshells of 56 chelonians were examined by electron microscopy and X-ray diffractometry. They classified into six types in terms the matrix structure their calcareous layer; type I was composed a thin layer with minerals an amorphous structure; II shell units mammillary cores calcified aragonite crystals; III cores, plus single palisade also crystals, each unit separated; IV same as III, but tightly packed together; V two layers; VI cuticle calcite crystals over that V. diffraction...

Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated dyslipidemia, hypertension insulin resistance, part of which are ameliorated by DPP-4 inhibitors, it remains unclear whether could anti-atherosclerotic properties directly attenuating the harmful effects hyperglycemia. Therefore, we examined inhibitor, teneligliptin, suppress oxidized...

Abstract Artificial manipulation of incubation temperature has been proposed as a potential strategy for mitigating the effects climate change on sea turtles which sex determination is temperature-dependent, but thermal may also affect hatchling survival. Here, we demonstrated that and water temperatures influenced several performance traits contribute to survival loggerhead ( Caretta caretta ) during post-hatchling dispersal phase. Hatchlings from warm (31 °C) had significantly shorter...

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert potent glucose-lowering effects without increasing risks for hypoglycemia and weight gain. Preclinical studies have demonstrated direct antiatherogenic of GLP-1RAs in normoglycemic animal models; however, the underlying mechanisms hyperglycemic conditions not been fully clarified. Here we aimed to elucidate role AMP-activated protein kinase (AMPK) mice. Streptozotocin-induced apolipoprotein E-null mice were treated with vehicle,...

SMTP-44D has been reported to have anti-oxidative and anti-inflammatory reactions, including reduced expression of receptor for advanced glycation end products (RAGE) in experimental diabetic neuropathy. Although activation RAGE with its ligands, (AGEs), play a crucial role atherosclerotic cardiovascular disease, leading cause death patients, it remains unclear whether could inhibit atherosclerosis by suppressing the AGEs-RAGE axis. In this study, we investigated effects on plaque formation...

We have developed DNA aptamers that can inhibit the toxic effects of advanced glycation end products (AGE-Apts). herein evaluated AGE-Apts on muscle mass and strength in senescence-accelerated mouse prone 8 (SAMP8) mice. Eight-month-old male SAMP8 mice received subcutaneous infusion control (CTR-Apts) or AGE-Apts. Mice an age-matched resistant strain 1 (SAMR1) group were treated with CTR-Apts as controls. The soleus muscles collected after 8-week intervention for weight measurement...

Tokophobia is regarded as the intensive fear of childbirth that some pregnant women have. However, little known about psychopathological details tokophobia (fear childbirth). Between 2020 and 2021, a total 10 (nine nulliparae one multipara) with strong were referred by obstetricians. Semi-structured interviews conducted, two cases judged to have obsession, three an overvalued idea, secondary delusion. Three characterised both obsession idea In total, six had features idea. All participants...

Type 2 diabetes mellitus (T2DM) is a risk factor for male infertility, but the underlying molecular mechanisms remain unclear. Advanced glycation end products (AGEs) are pathogenic molecules diabetic vascular complications. Here, we investigated effects of DNA-aptamer raised against AGEs (AGE-Apt) on testicular and sperm abnormalities in T2DM mouse model. KK-Ay (DM) wild-type (non-DM) 4- 7-week-old mice were sacrificed to collect testes spermatozoa immunofluorescence, RT-PCR, histological...

We verified whether telomere length shortens with age in the loggerhead sea turtle (Caretta caretta) by measuring lengths (relative to single copy gene [T/S] ratios) whole blood and epidermis from 20 captive individuals a real-time PCR method. There was no significant correlation between relative T/S ratios blood. Although not significant, older turtles had smaller epidermis. It thus demonstrated that could be useful estimator for turtles. Relative information obtained this simple, rapid,...

A longevity gene product, Sir2 (silent information regulator 2) is a NAD-dependent histone deacetylase involved in yeasts, worms and flies. The mammalian homolog of Sir2, SIRT1(sirtuin 1), has been shown to play important roles related anti-aging effects (regulating apoptosis, stress tolerance, insulin resistance, fat metabolism). Recently, SIRT1 expression demonstrated occur at as early embryonic day 10.5 mice. during developing period may be the mechanism developmental origins adult...