A5021134976- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- Maternal and Perinatal Health Interventions
- Preterm Birth and Chorioamnionitis
- Respiratory Support and Mechanisms
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Ectopic Pregnancy Diagnosis and Management
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- COVID-19 Impact on Reproduction
- Child and Adolescent Health
- Fetal and Pediatric Neurological Disorders
- Herpesvirus Infections and Treatments
- Congenital Diaphragmatic Hernia Studies
- Immunodeficiency and Autoimmune Disorders
- Pregnancy-related medical research
- Cytomegalovirus and herpesvirus research
- Infant Development and Preterm Care
University of Helsinki
2013-2024
Helsinki University Hospital
2013-2024
Helsinki Children's Hospital
2001-2021
Children's Hospital
2018-2019
Center for Children
2003
Uppsala University
1999
Section:ChooseTop of pageAbstract <<PATIENTSMETHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
Objective. To assess neutrophil CD11b and circulating interleukin 8 (IL-8) as markers of early-onset infection in neonates. Methods. The study comprised 39 neonates, with a gestational age 29 to 41 weeks, suspected within 48 hours life. Neutrophil surface expression was quantified flow cytometry plasma IL-8 an enzyme-linked immunosorbent assay. Both data were available from 35 Serum C-reactive protein determined at initial evaluation and, later, on the basis clinical picture. Neonates...
Congenital cytomegalovirus (cCMV) infection is the most common congenital and causes significant morbidity. This study was undertaken to evaluate benefits of screening newborns for cCMV understand disease burden in Finland.Infants born Helsinki area hospitals were screened CMV by testing their saliva with a real-time polymerase chain reaction assay. The CMV-positive infants matched controls monitored determine neurodevelopmental, audiological, ophthalmological outcomes at 18 months age....
Abstract Background To investigate the trends and changes in incidence overall outcome of twin pregnancies Finland, a retrospective study was conducted with emphasis on maternal complications, covering 28-year period. Methods All 23,498 46,363 live born 633 stillborn children Finland during 1987–2014 were included study. Data collected from national Medical Birth Register Care Hospital (Finnish Institute for Health Welfare, Finland) regarding parturients’ characteristics incidences several...
OBJECTIVE. In preterm infants with respiratory distress syndrome (RDS), circulating neutrophils are activated. Kinetics and effects of surfactant therapy on this activation unknown. Therefore, we studied monocytes in newborn without RDS. PATIENTS AND METHODS. Preterm RDS who were mechanically ventilated received (“ventilated infants”: n = 38; mean gestational age ± SD: 28.3 2.2 weeks; birth weight 1086 353 g) nasal continuous positive airway pressure (n 8) or no ventilatory support 17)...
Outcome after intrauterine transfusions due to severe hemolytic disease of the fetus and newborn.Nationwide population-based retrospective cohort study.All women treated with for newborn in Finland 2003-2012.339 transfusions, performed 104 pregnancies 84 women.Information on antenatal screening red cell antibodies units issued transfusion was obtained from Finnish Red Cross Blood Service database, obstetric neonatal data hospital records.Procedure-related complications, perinatal mortality,...
Introduction . Intra-amniotic infection (IAI) is a major cause of preterm labor and adverse neonatal outcome. We evaluated amniotic fluid (AF) proteolytic cascade forming biomarkers in relation to microbial invasion the cavity (MIAC) IAI pregnancies with intact membranes. Material Methods Amniocentesis was made 73 women singleton pregnancies; 27 suspected IAI; 46 controls. AF were divided into three cascades: Cascade 1: matrix metalloproteinase-8 (MMP-8), MMP-9, myeloperoxidase (MPO),...
Objective. To study neutrophil activation in circulation as a sign of systemic inflammation preterm infants with respiratory distress syndrome. Methods. The comprised very low birth weight who had syndrome and required intubation mechanical ventilation (n = 51), 1-day-old no need for 12), term 47), adult volunteers 25). Neutrophil surface expression CD11b was quantified flow cytometry. Results. In syndrome, during the first day life higher than cord blood (mean: 165 relative fluorescence...
<i>Background:</i> Preterm infants with respiratory distress syndrome (RDS) present systemic inflammation. The role of lymphocytes in RDS is less studied. Activation could mediate chronic inflammation and development bronchopulmonary dysplasia (BPD). <i>Objective:</i> To evaluate whether T cells are activated preterm cell activation associated the BPD. <i>Methods:</i> Thirty-four [mean gestational age 27.1 (SD 2.0) weeks, birth weight 900 (216) g] were...
Neonatal sepsis (NS) is a frequent problem in neonatal intensive care, especially preterm and very low birthweight (VLBW) infants. The objective of the study was to characterize cutaneous bacterial microbiome VLBW infants treated care unit (NICU). Non-invasive skin specimens were taken repeatedly from 12 during treatment NICU starting on first day life. All received benzylpenicillin netilmicin 1-5 postnatal days. Samples also collected incubators. High microbial diversity present at birth 11...
Abstract Immaturity of the immune system renders newborns susceptible to infections. We searched for aberrations in leucocyte signalling profiles, using phospho‐specific whole‐blood flow cytometry, cord blood nine preterm (two born before 32nd gestational week) and full‐term infants, by caesarean section. Thirteen adults served as reference subjects. Monocyte NF ‐κB phosphorylation following tumour necrosis factor ( TNF ) or bacterial stimulation was higher neonates than adults, p38 both...
Abstract Introduction Although the perinatal mortality of monochorionic twins has been reported to be higher, role chorionicity is debated and data from Finland are still lacking. To examine effect on main outcome measures, neonatal morbidity Finnish twins, a comprehensive population‐based historical cohort study was performed at Helsinki University Hospitals. Material methods All 1034 dichorionic monochorionic‐diamniotic twin pregnancies managed Hospital area during 2006, 2010, 2014 2018...
To establish the changes in perinatal morbidity and mortality twin pregnancies Finland, a retrospective register research was conducted. Our extensive data from 28-year study period provide important information on outcome of Finland that has previously not been reported to this extent.
Abstract Introduction Labor induction rates are increasing and, in Finland today, one of three labors is induced. Group B streptococcus (GBS) a bacterium found 10%–30% pregnant women and it can be transmitted to the neonate during vaginal delivery. Although GBS rarely harmful general population, leading cause severe neonatal infections such as sepsis, pneumonia, meningitis. In addition, maternal morbidity. GBS‐positive has not yet been investigated but concerns infectious morbidity...
We evaluated the concentrations of vascular endothelial growth factor (VEGF) and angiogenin in umbilical cord blood from 14 fetuses with erythroblastosis or alloimmune thrombocytopenia at birth 28 preterm fetuses, 42 healthy term 24 born to mothers insulin-treated diabetes. A correlation appeared between VEGF levels (r = 0.44, p 0.038). The gestational age correlated both 0.38, 0.0008) 0.80, 0.0001). concentration was lower diabetes than (p 0.0028), but this difference absent for > 0.05)....
<i>Background:</i> Preeclampsia and preterm labor often underlie birth, are associated with maternal inflammation. In infants, respiratory distress syndrome (RDS) mechanical ventilation systemic <i>Objective:</i> We aimed to study whether early-onset preeclampsia or modulate the inflammation affecting infants RDS. <i>Methods:</i> recruited mechanically ventilated gestational ages <32 weeks; 11 were born after 25 labor. Blood was drawn during postnatal...
Meconium drug testing is a non‐invasive method to detect prenatal exposure, which can cause severe problems for the infant, indicating need follow‐up measures ensure welfare of child. samples were collected from 143 infants as part routine clinical work among addicted mothers. The findings combined with medical records including background and data. substances screened included medicinal opioids, 6‐monoacetylmorphine (a metabolite heroin), amphetamines tetrahydrocannabinolic acid. At least...
To describe labor outcomes in women with prolonged pregnancy and induction of a Foley catheter, as compared spontaneous onset labor.Retrospective study.Helsinki University Hospital.553 uncomplicated pregnancies between January 2011 2012, divided into 303 (54.8%) catheter 250 (45.2%) labor.Maternal neonatal characteristics singleton ≥41(+5) weeks gestation were analyzed.Cesarean delivery rates, maternal morbidity.The cesarean rate was 30.7% (n = 93/303) 4.8% (12/250) (p < 0.001). The 37.3%...
Children with congenital CMV infection (cCMV) shed virus in urine and saliva for prolonged periods of time. Outcome cCMV varies from asymptomatic no sequelae most cases, to severe longterm morbidity. The factors associated are not well defined. We evaluated the viral shedding a cohort infants identified on newborn screening. In addition, we describe distribution genotypes our previous cohorts children literature. Study population consisted 40 screening 19,868 infants, prevalence 2/1000. was...