A5007179023- Cancer Cells and Metastasis
- Medicinal Plant Pharmacodynamics Research
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Flavonoids in Medical Research
- Liver physiology and pathology
- Mesenchymal stem cell research
- Bone Tumor Diagnosis and Treatments
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Cardiac tumors and thrombi
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Traditional Chinese Medicine Analysis
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
Third People's Hospital of Hangzhou
2020-2024
Zhejiang Chinese Medical University
2018-2022
Zhejiang University
2022
Beijing Jiaotong University
2021
Aim: To evaluate the relationship between tumor size and survival in metastatic colorectal cancer (mCRC) patients who received chemotherapy. Materials & methods: SEER database was accessed for eligible patients. Multivariate Cox regression analysis performed to compare effect of on overall (OS) CRC-specific (CCSS). Results: Tumor ≥5 cm an independent risk factor OS CCSS mCRC treated with <5 did not show a advantage whose primary site rectosigmoid junction, while associated poor left-and...
CXC chemokine receptors (CXCRs) and chemokines are involved in tissue development homeostasis, including cancer progression. To date, seven CXCRs have been identified. However, the expression of their influence on occurrence breast (BC) requires further investigation. In present study, mRNA levels were compared between normal tissues several types using Oncomine database. Highly expressed selected these examined different subtypes BC Gene Expression‑Based Outcome for Breast Cancer Finally,...
Ethnopharmacology relevance: Jiedu Sangen Decoction (JSD), an empirical prescription of Traditional Chinese Medicine (TCM), has been reported to inhibit invasion and metastasis colon cancer in our previous study. The aim this study was investigate the mechanism JSD-triggered inhibition cancer. Methods:In vitro, AKT1 knockdown (si-AKT1) or overexpression (oe-AKT1) cells were successfully constructed both SW480 SW620 cell lines. Si-AKT1 oe-AKT1 then treated with without JSD. Cell invasion,...
BACKGROUND The protein 4.1 family is a of cytoskeletal proteins that play an important role in maintaining normal cell morphology and adhesion, migration, division, intercellular signaling. main aim this study was to explore the prognostic significance breast cancer (BC) patients provide new biomarkers therapeutic targets for diagnosis treatment BC. MATERIAL AND METHODS expression members various tumor types compared controls using ONCOMINE GOBO databases. BC determined by Kaplan-Meier...
Background: Jiedu Sangen Decoction (JSD), a traditional Chinese medicine formula, has been widely applied in the treatment of gastrointestinal cancer, especially colorectal cancer. Our study mainly aimed to assess combined efficacy aqueous extract (JSAE) and PD-L1 inhibitor (PI) colon cancer cells migration invasion, along with epithelial-mesenchymal transition, then provide deep insights into potential mechanism. Methods: We explored inhibitory effects on invasion metastasis reverse effect...
Jiedu Sangen Decoction (JSD), a traditional Chinese medicine (TCM) formula, has been widely used in China to treat gastrointestinal cancer, especially as an adjuvant therapy colorectal cancer (CRC) patients. This study aimed evaluate the efficacy of JSD and aqueous extract (JSAE) colon cells explored underlining mechanisms by cytotoxicity assay, scratch transwell migration matrigel invasion confocal laser scanning microscopy, western blot analysis. We demonstrated that JSAE inhibited growth...
Background Gastric cancer (GC) stem cells play an important role in GC progression. Circular RNAs (circRNAs) act as microRNA (miRNA) sponges and inhibit the biological function of miRNAs cytoplasm. MiRNAs also participate progress. circ_0051246 was shown to be associated with miR-375 after analyzing microarray data GSE78091 GSE83521 . The oncoprotein Yes-associated protein 1 (YAP1) is targeted by can inactivated via Hippo tumor suppressor pathway. Due insufficient research on circ_0051246,...
Qingfei Gujin Decoction (QGD) has been shown to be effective against osteosarcoma. This research was aimed at investigating the main active ingredients and potential mechanisms of QGD acting on osteosarcoma through network pharmacology molecular docking techniques.
Generally, pelvic osteosarcoma has a worse prognosis compared with limb osteosarcoma. This study aims to create and validate new nomogram for predicting the of
Abstract Aim : Qingfei Gujin decoction (QGD) has been shown to be effective against osteosarcoma. This research was aimed investigate the main active ingredients and potential mechanisms of QGD acting on osteosarcoma through network pharmacology molecular docking techniques. Methods The targets were screened from TCMSP database, predicted obtained PharmMapper database. Meanwhile, collected using OMIM, PharmGkb DisGeNET databases. Then, GO KEGG enrichment analysis performed by RStudio. PPI...
Non-small cell lung cancer (NSCLC) is prevalent worldwide and has a high mortality rate. Even if mesenchymal stem cells (MSCs) are suggested as treatment, the studies of their effects on NSCLC contradict each other, mainly due to utilization two-dimensional (2D) culture system. Three-dimensional (3D) systems resemble tissue organization in vivo. Here we comprehensively explore inhibitory MSCs 3D We confirmed that 3D-cultured (3D-MSCs) proliferation migration greater than 2D-cultured MSCs....