A5066406781- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Neonatal Respiratory Health Research
- Child Development and Digital Technology
- Family and Disability Support Research
- Neurological Complications and Syndromes
- RNA modifications and cancer
- Prenatal Screening and Diagnostics
- Neurogenetic and Muscular Disorders Research
- Maternal and Perinatal Health Interventions
- Heavy Metal Exposure and Toxicity
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Moyamoya disease diagnosis and treatment
- Preterm Birth and Chorioamnionitis
- Cognitive Abilities and Testing
- Child and Animal Learning Development
- Medical Education and Admissions
- Pregnancy and Medication Impact
- Hemophilia Treatment and Research
- Cardiac Arrest and Resuscitation
- Autoimmune and Inflammatory Disorders Research
Beth Israel Deaconess Medical Center
2013-2024
Harvard University
2013-2023
Beth Israel Deaconess Hospital
2020-2022
Lemuel Shattuck Hospital
2020-2022
Medical University of South Carolina
2020
Cure Spinal Muscular Atrophy
2019
The University of Queensland
2011-2019
Harvard Stem Cell Institute
2016
London Health Sciences Centre
2015
Mater Children's Hospital
2014
Objective: This guideline provides evidence‐based recommendations on managing hoarseness (dysphonia), defined as a disorder characterized by altered vocal quality, pitch, loudness, or effort that impairs communication reduces voice‐related quality of life (QOL). Hoarseness affects nearly one‐third the population at some point in their lives. applies to all age groups evaluated setting where would be identified managed. It is intended for clinicians who are likely diagnose and manage patients...
In lung cancers with low expression of C/EBPα, BMI1 correlates worse prognosis but can be targeted a drug.
Phthalates are reproductive toxicants commonly found in personal care products (PCPs). These endocrine disrupting chemicals associated with pregnancy complications, including gestational diabetes. Yet, little is known about PCP use as a contributor to urinary phthalate metabolite concentrations pregnancy. We conducted pilot study among 108 pregnant participants examine the associations of self-reported 14 and 2 DINCH (di(isononyl) cyclohexane-1,2-dicarboxylate) measured single spot urine...
Prenatal exposure to endocrine disrupting chemicals (EDCs) from personal care products may be associated with birth outcomes including preterm and low weight. There is limited research examining the role of product use during pregnancy on outcomes. Our pilot study consisted 164 participants in Environmental Reproductive Glucose Outcomes (ERGO) (Boston, MA), data self-reported at four visits throughout (product 48 h before a visit hair month visit). We used covariate-adjusted linear...
Background: Research indicates that having child siblings is positively associated with theory of mind (ToM) in typically developing children. As ToM important to everyday social behaviours it extend this research examine whether there are similar sibling effects for children autism spectrum disorders (ASD). Methods: Theory and executive functioning abilities 60 clinically diagnosed ASD were assessed batteries standard tasks. Verbal mental age (VMA) severity symptoms also measured together...
Abstract Mild traumatic brain injury is a relatively common event in contact sports and there increasing interest the long-term neurocognitive effects. The diagnosis largely relies on symptom reporting need for objective tools to aid prognosis. There are recent reports that blood biomarkers could potentially help triage patients with suspected normal CT findings. We have measured plasma concentrations of glial neuronal proteins explored their potential assessment mild sport. recruited...
Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence birth compared to other racial/ethnic groups and may be disproportionately exposed EDCs through EDC-containing hair products. However, research on the use EDC-associated products during pregnancy is lacking. Therefore, objective this pilot study was estimate associations prenatal product gestational age at delivery...
Abstract Growth and nutrition in preterm infants have long‐term implications for neurodevelopmental cardiometabolic outcomes. Many are discharged from the neonatal intensive care unit (NICU) with growth restriction, but often without a specialized team to monitor postdischarge growth. At our institution, we addressed ongoing concerns health of these post‐discharge by creating Nutrition NICU Graduate Clinic. This clinic serves who were born very low birth weight, had difficulty growing or...
Abstract Objective To examine time trends in US pregnant women with type 1 diabetes mellitus for maternal characteristics and pregnancy outcomes. Study design We abstracted clinical data from the medical records of 700 2004 to 2017. For each period, means percentages were calculated. P values trend calculated using linear logistic regression. Results HbA1c trimester was unchanged across analysis period. The prevalence nephropathy decreased 4.8% 0% ( = 0.002). Excessive gestational weight...
A rat model was designed to determine if fetal dexamethasone exposure is associated with decreased insulin sensitivity in adulthood, manifested as binding of p85 phosphorylated receptor substrate-1 (IRS-1) within the phosphatidylinositol 3-kinase (PI 3-kinase) pathway signaling. Additionally, study investigated whether a differential effect exists male and female rodent offspring, such that females demonstrate IRS-1 after utero. Timed-pregnant Sprague-Dawley rats received either tap water or...
Autism is an etiologically heterogeneous developmental disorder for which the range of genetic investigations has expanded considerably over past decade. Introduction chromosomal microarray (CMA) to clinical practice conditions pediatricians are able detect. This study reviewed utilization, yield and cost in a sample children with pervasive disorders (PDD) Australian metropolitan child development service. Six hundred ninety eight patients PDD were identified from clinic population. One ten...
To examine the clinical utility and cost of follow-up ultrasounds performed as a result suboptimal views at time initial second-trimester ultrasound in cohort low-risk pregnant women.We conducted retrospective study women low risk for fetal structural anomalies who had 16 to less than 24 weeks gestation from 2011 2013. We determined probability having ultrasound, calculated detecting an anomaly on ultrasound. These probabilities were used estimate national our current practice, identify one...
Transient myeloproliferative disorder (TMD), also known as transient acute myelopoiesis, is a condition that occurs in the perinatal period up to 10% of patients who have Down syndrome. Because presentation this disorder, neonatal clinicians should be familiar with its clinical presentation, management, and outcomes. Affected develop severe myeloproliferation megakaryocytic precursor cells, leading initially hepatosplenomegaly liver dysfunction. If develops prenatally, affected fetuses may...
Our objective was to assess the effectiveness, safety and efficiency of a protocol combining fetal fibronectin diagnostic testing atosiban tocolysis for management pre-term labour, using combination narrative review economic modelling. We compared proposed alternatives nifedipine with or without fibronectin. have found that may be safer more acceptable by women than alternatives, its use can result in significant cost-savings.