A5081518650- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Gynecological conditions and treatments
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Reproductive Physiology in Livestock
- Reproductive Health and Contraception
- Angiogenesis and VEGF in Cancer
- Renal and related cancers
- HER2/EGFR in Cancer Research
ID Genomics (United States)
2023
CooperSurgical (United States)
2023
Baylor College of Medicine
2010-2014
University of Chicago
2010
To determine the pregnancy outcome potential of mosaic embryos, detected by means preimplantation genetic screening (PGS) with use next-generation sequencing (NGS).Retrospective study.Genetics laboratories.PGS cycles during which either or euploid embryos were replaced.Blastocysts biopsied and processed NGS, followed frozen embryo transfer. Trophectoderm (TE) biopsies classified as if they had 20%-80% abnormal cells.Implantation, miscarriage rates, ongoing implantation rates (OIRs) compared...
During embryonic development, Foxa2 is required for the formation of node and notochord, ablation this gene results in defects gastrulation, neural tube patterning, gut morphogenesis. has been shown to be expressed specifically glandular epithelium murine uterus. To study uterine function Foxa2, was conditionally ablated mouse uterus by crossing mice with floxed alleles, Foxa2(loxP/loxP), Pgr(cre) model. Pgr(cre/+) Foxa2(loxP/loxP) showed significantly reduced fertility. Analysis on Day 5.5...
The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. PR expression in these cellular compartments under tight temporal endocrine control. Although ex vivo studies demonstrated importance of stromal expression, they failed to show a role epithelial uterine Here, epithelium defined using floxed (PRf/f) mice crossed Wnt7a-Cre mice. Progesterone was...
Infertility and adverse gynecological outcomes such as preeclampsia miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. goal this study is to define the ERBB family factor receptors endometrial function. Using conditional ablation mice siRNA primary human stromal cells, we identified epidermal receptor (Egfr) be critical for function during early While Her2 or Erbb3 led...
Implantation of a blastocyst in the uterus is multistep process tightly controlled by an intricate regulatory network interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands receptors are expressed pregnant mice, BMP2 has been shown to be key regulator implantation. In this study, we investigated roles BMP type 1 receptor, activin-like kinase 2 (ALK2), during mouse pregnancy producing mice carrying conditional ablation Alk2 (Alk2 cKO mice). absence...
Abstract Purpose To investigate the role of standardized preimplantation genetic testing for aneuploidy (PGT-A) using artificial intelligence (AI) in patients undergoing single thawed euploid embryo transfer (STEET) cycles. Methods Retrospective cohort study at a single, large university-based fertility center with vitro fertilization (IVF) utilizing PGT-A from February 2015 to April 2020. Controls included embryos tested subjective NGS. The first experimental group analyzed by NGS AI and...
Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII; NR2F2) is an orphan nuclear receptor involved in cell-fate specification, organogenesis, angiogenesis, and metabolism. Ablation of COUP-TFII the mouse uterus causes infertility due to defects embryo attachment impaired uterine stromal cell decidualization. Although function decidualization has been described mice, its role human remains unknown. We observed that, as robustly expressed endometrial stroma healthy women,...
The establishment of the appropriate embryo-uterine interactions required for successful implantation and pregnancy require coordinate actions growth factors their receptors. spatiotemporal expression Erbb ligands receptors in periimplantation uterus embryo suggests that they play a role reproduction. Numerous have overlapping patterns during pregnancy, gene ablations individual do not show major uterine phenotype due to compensation by other family members. We identified EGFR (ERBB1) as...
Abstract Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) action. A bias toward E2 action away from P4 underlies the tumorigenesis adenocarcinoma which is fourth most common cancer in women. In previous studies, we have identified mitogen-inducible gene 6 (Mig-6) as downstream target PR (progesterone receptor) uterus. Mig-6 expressed both epithelium stroma Conditional ablation all compartments uterus (PRcre/+ Mig-6f/f) results infertility leads to...
Abstract Endometrial cancer is the most common gynecological cancer. Estrogen-dependent endometrioid carcinoma type of endometrial In previous studies, we have identified mitogen-inducible gene 6 (Mig-6) as a downstream target Progesterone Receptor (Pgr) action in uterus. Ablation Mig-6 murine uterus leads to development hyperplasia and estrogen-induced These results suggest that act tumor suppressor To assess effects overexpression PTEN/PI3K/AKT signaling pathways on uterine tumorigenesis,...
Abstract Introduction and Objective High-grade, muscle invasive urothelial bladder cancer is common in the United States worldwide. microRNAs (miRNA) are highly conserved, endogenously-encoded small RNAs that modulate gene expression involved a variety of physiological processes disease states. A large body literature has proven alterations miRNA function contribute to development. We others have reported altered miRNAs human cancers. In previous microarray experiment, we demonstrated miR-1...
Adenomyosis is a common gynecological disorder defined by the presence of endometrial glands and stroma within myometrium. Despite its frequent occurrence, precise etiology adenomyosis still unknown, although it has often been associated with endometrioid adenocarcinoma. β-catenin abnormalities are in type carcinomas. The expression dominant stabilized murine uterus (PRcre/+ Ctnnb1f(ex3)/+) resulted glandular hyperplasia. In addition to hyperplasia phenotype, uteri PRcre/+ Ctnnb1f(ex3)/+...