A5091199010- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Child Development and Digital Technology
- Eating Disorders and Behaviors
- Congenital heart defects research
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Virology and Viral Diseases
- RNA Research and Splicing
- RNA modifications and cancer
- Cerebral Palsy and Movement Disorders
- Genomics and Chromatin Dynamics
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Morphological variations and asymmetry
- Dermatoglyphics and Human Traits
- Hemispheric Asymmetry in Neuroscience
- Salmonella and Campylobacter epidemiology
- Dementia and Cognitive Impairment Research
- Genomic variations and chromosomal abnormalities
- Hair Growth and Disorders
- Impact of Technology on Adolescents
- Adolescent and Pediatric Healthcare
- Health, Environment, Cognitive Aging
Stockholm Health Care Services
2019-2025
Karolinska Institutet
2018-2025
Uppsala University Hospital
2023
Baylor College of Medicine
2023
NeuroDevelopment Center
2020-2022
Stockholm County Council
2018-2022
National Institute for Environmental Studies
2022
Icahn School of Medicine at Mount Sinai
2022
Abstract Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread regions. The possible impacts these regional alterations terms structural network effects not previously characterized. Inter-regional morphological covariance analysis can capture connectivity between different areas at macroscale level. Here, we used data from 1455 ASD...
Functioning is a construct capturing how an individual’s engagement in everyday life emerges from the interaction between individual and their environment. The World Health Organization’s International Classification of Functioning, Disability (ICF) provides biopsychosocial framework functioning. Previously, ICF was adapted for use autism by developing Core Sets, selection codes entire classification specific conditions. Here, we present first revision sets Delphi-like technique, based on...
Abstract Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, existing findings lack consistency or are restricted to particular brain region, specific feature, relatively narrow age range. Here, we investigated associations asymmetry as well sex in one largest pediatric samples date ( n = 4265), aged 1–18 years, scanned at 69 sites participating ENIGMA (Enhancing NeuroImaging Genetics through...
Alterations in social cognition (SC) are hypothesized to underlie communication and interaction challenges autism spectrum disorder (ASD). The aetiological underpinnings driving this association remain unclear. We examined SC 196 twins with ASD, other neurodevelopmental disorders or typical development using the naturalistic Movie for Assessment of Social Cognition. Autism its severity were assessed Diagnostic Observation Schedule-2, autistic traits Responsiveness Scale-2. Using within...
Atypical sensory processing is prevalent across neurodevelopmental conditions and a key diagnostic criterion of autism spectrum disorder. It may have cascading effects on the development adaptive functions. However, its unique contribution to functioning genetic/environmental influences this link are unclear. In clinically enriched twin sample ( n = 289, 60 diagnosed with disorder), we investigated associations between quadrants Adult/Adolescent Sensory Profile (low registration,...
Given that camouflaging has been suggested to contribute delayed diagnosis and mental health problems among autistic people, validated measures of the construct are needed. This study describes psychometric evaluation Swedish adaptation self-reported Camouflaging Autistic Traits Questionnaire (CAT-Q) in (n = 100) general population 539) samples aged 10 83 years. Analyses indicated good-to-excellent internal consistency test-retest reliability. Construct validity was supported by participants...
Abstract Aim To conduct the first revision of World Health Organization International Classification Functioning, Disability and (ICF) Core Sets for attention‐deficit/hyperactivity disorder (ADHD). Method A Delphi‐like method was used, integrating evidence from stakeholder feedback developing piloting ADHD ICF Set platform to inform revisions Sets. Results total 27 second‐level codes were added comprehensive Set: body functions temperament personality, basic sensory functions; activities...
Abstract The International Classification of Functioning, Disability and Health (ICF) is the World Organization’s (WHO) standard for assessing individual functioning. Over last decade, ICF has been made more accessible autism ADHD through development validation tailored shorter versions these diagnoses, Core Sets. To further enhance their applicability in research practice, Sets have operationalized implemented on an online platform, CoreSets platform. Here, we describe iterative process...
Few studies have addressed gender differences in autism relation to functioning and across cultures. We aimed explore functional from a multidisciplinary, global perspective using the International Classification of Functioning, Disability, Health. Perceptions among professionals high-income countries middle-income were examined based on qualitative survey data N = 225 professionals. Of these, n 131 provided information autism. Thirty-two reported perceiving no differences. Remaining...
Autism spectrum disorder is associated with sensory processing alterations, such as hyper- and hypo-responsiveness. Twin studies are scarce in this field, but they necessary order to disentangle the genetic environmental contributions association. Furthermore, it unclear how different neurodevelopmental/psychiatric conditions contribute altering processing. We investigated association between autistic traits/autism diagnosis alterations twins ( N = 269), using adult/adolescent profile, which...
This study investigated the association between autism and self-reported eating problems influence of gender on association, in a sample adolescent adult twins (N = 192). Autistic traits diagnosis were associated with both total specific problems, including selective sensory sensitivity during mealtimes. Interaction effects indicated stronger autistic females, as well more difficulties social contexts among females. In within-pair analyses, where unmeasured confounders genes shared...
Genetic variants affecting Heterogeneous Nuclear Ribonucleoprotein U (HNRNPU) have been identified in several neurodevelopmental disorders (NDDs). HNRNPU is widely expressed the human brain and shows highest postnatal expression cerebellum. Recent studies investigated role of cerebral cortical development, but effects deficiency on cerebellar development remain unknown. Here, we describe molecular cellular outcomes locus during vitro neural differentiation patient-derived isogenic...
Background Autism Spectrum Disorder ( ASD ) is associated with altered global and local visual processing. However, the nature of these alterations remains controversial, contradictory findings notions ranging from a reduced drive to integrate information into coherent ‘gestalt’ (“ weak central coherence ” = WCC an enhanced perceptual functioning EPF in Methods This study assessed association between autism global/local processing, using large sample monozygotic MZ dizygotic DZ twins N 290,...
Abstract No robust biomarkers have yet been identified for autism spectrum disorder (ASD) or autistic traits. Familial factors likely influence such as protein concentrations. Comparing twins with ASD high traits to the less affected co‐twin allows estimating impact of familial confounding. We measured 203 proteins in cerebrospinal fluid ( n = 86) and serum 127) (mean age 14.2 years, 44.9% females) enriched other neurodevelopmental conditions. Autistic were assessed by using parent‐report...
Abstract Background A significant proportion of variation in likelihood neurodevelopmental conditions (NDCs) has been attributed to nonshared environmental (NSE) factors, although it remains unclear which NSE factors pose specific risks for certain NDCs. Methods monozygotic co-twin design was applied a sample 224 twins (mean age = 17.70 years, SD 6.28) controlling confounders such as genes and shared environment. Generalized estimating equation models were fitted, using perinatal postnatal...
Autism spectrum disorder (ASD) is a neurodevelopmental condition diagnosed in approximately 2% of children. Reliance on the emergence clinically observable behavioral patterns only delays mean age diagnosis to 4 years. However, neural pathways critical language and social functions develop during infancy, current diagnostic protocols miss when therapy would be most effective. We developed non-invasive ASD biomarkers using mass spectrometry analyses elemental metabolism single hair strands,...
A considerable number of screening and diagnostic tools for autism exist, but variability in these measures presents challenges to data harmonization the comparability generalizability findings. At same time, there is a movement away from symptomatology stances that capture heterogeneity appreciate diversity. The International Classification Functioning, Disability Health (ICF) provides classification system can support content different while enabling translation information into...
Several Proficiency Test (PT) or External Quality Assessment (EQA) schemes are currently available for assessing the ability of laboratories to detect and characterize enteropathogenic bacteria, but they usually targeting one sector, covering either public health, food safety animal health. In addition sector-specific PTs/EQAs detection, cross-sectoral panels would be useful assessment capacity foodborne pathogens in a One Health (OH) perspective further improving interpretation surveillance...
Autism is a neurodevelopmental condition associated with atypical social communication, cognitive, and sensory faculties. Recent advances in exposure biology suggest that biomarkers of elemental uptake metabolism measured hair samples can yield an effective signal predictive autism diagnosis. Here, we investigated if were functional connectivity regions the default mode network (DMN) previously linked to autism. In study sample which included twin pairs concordant discordant diagnoses for...
Alterations in social cognition are hypothesized to underlie communication challenges autism spectrum disorder. However, the etiologic underpinnings driving this association, as well impact of other psychiatric conditions on remain unclear. Using a co-twin control design, we examined n = 308 twins (mean age 16.63; 46% females) with disorder, attention-deficit/hyperactivity affective disorders, or typical development using Reading Mind Eyes Test operationalize ability. Clinical diagnosis...
Physical examinations are recommended as part of a comprehensive evaluation for individuals with neurodevelopmental disorders (NDDs), such autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder. These should include assessment morphological variants. Previous studies have shown an increase in variants NDDs, particularly ASD, that these may be present greater amounts genetic alterations. Unfortunately, can subjective time-consuming, require high degree clinical expertise....
Atypical regulation of inflammation has been proposed in the etiology autism spectrum disorder (ASD); however, measuring temporal profile fetal associated with future ASD diagnosis not possible. Here, we present a method to generate approximately daily profiles prenatal and early childhood as measured by developmentally archived C-reactive protein (CRP) incremental layers deciduous tooth dentin. In our discovery population, group Swedish twins, found heightened third trimester children...
<title>Abstract</title> Autism spectrum disorder (ASD) is a neurodevelopmental condition diagnosed in approximately 2% of children. Reliance on the emergence clinically observable behavioral patterns only delays mean age diagnosis to 4 years. However, neural pathways critical language and social functions develop during infancy current diagnostic protocols miss when therapy would be most effective3,4. We developed non-invasive ASD biomarkers using mass spectrometry analysis elemental...