A5002373543- Migraine and Headache Studies
- Health, Environment, Cognitive Aging
- Menopause: Health Impacts and Treatments
- Vitamin D Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Estrogen and related hormone effects
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Cancer Immunotherapy and Biomarkers
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- Urological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Metabolomics and Mass Spectrometry Studies
- Psoriasis: Treatment and Pathogenesis
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Mast cells and histamine
- Glaucoma and retinal disorders
Sun Yat-sen University
2023-2024
Sun Yat-sen Memorial Hospital
2023-2024
Guangzhou Medical University
2023
Key Laboratory of Guangdong Province
2023
Erasmus MC
2012-2021
Hunan Normal University
2018-2021
Hunan Provincial Center for Disease Control and Prevention
2020-2021
Amsterdam Neuroscience
2019
Vrije Universiteit Amsterdam
2019
Leiden University
2019
Limited evidence is available about the association between serum uric acid and sub-stages of spectrum from normoglycaemia to type 2 diabetes mellitus. We aimed investigate risk prediabetes Eligible participants Rotterdam Study (n = 8,367) were classified into mutually exclusive subgroups 7,030) 1,337) at baseline. These followed up for incident 1,071) mellitus 407), respectively. used Cox proportional hazard models determine ratios (HRs) among individuals with prediabetes. The mean duration...
Converging evidence suggests that migraine has, in part, a vascular basis. In turn, pathology is strong risk factor for cognitive decline. this population-based study, we studied cognition amongst individuals with and without migraine.In 6708 participants of the Rotterdam Study, was assessed using validated questionnaire. Cognition by Mini Mental State Examination (MMSE) dedicated test battery. Participants were classified as non-migraineurs (n = 5399), migraineurs 1021) or probable 288)....
The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOEɛ4 genotype. In 5,705 participants (mean age: 63.9±9.1 years; 57.4% women) from population-based Rotterdam Study, we investigated relationship between over a 5.5-year period examined potential effect modification We found that current was related to in global cognition [difference compared never smoking: -0.06 (95% C.I.-0.10;-0.01)], as well on specific tests including Letter Digit...
Abstract Background The previous study investigated whether the functions of small, medium, and large high density lipoprotein (S/M/L-HDL) are correlated with protein changes in mice. Herein, proteomic functional analyses (HDL) subclasses were performed humans rats. Methods After purifying S/M/L-HDL from healthy ( n = 6) rats 3) using fast liquid chromatography (FPLC) calcium silica hydrate (CSH) resin, analysis by mass spectrometry was conducted, as well capacities cholesterol efflux...
Abstract Background Right heart failure (RHF) is a complication of pulmonary hypertension (PH) and increases the mortality independently underlying disease. However, process RHF development progression not fully understood. We aimed to develop effective approaches for early diagnosis precise evaluation RHF. Methods ventricle (RV) pressure overload was performed via artery banding (PAB) surgery in Sprague–Dawley (SD) rats induce Echocardiography, right catheterization, histological staining,...
Background To explore the role of large-artery atherosclerosis in migraine, we investigated association between migraine and arterial calcification different intracranial extracranial vessels. Methods 1856 participants were included, mean age (standard deviation) 67.4 (5.8) years, from population-based Rotterdam Study cohort. Migraine was assessed by validated questionnaire vascular computed tomography (expressed Agatston score for coronary arteries volume mm 3 aortic arch, intracranial,...
The unfolded protein response (UPR) is one of a switch autophagy and apoptosis, the endoplasmic reticulum stress (ERS) which inducing UPR plays role in malformations caused by some genetic environmental factors. Exposure to flutamide during pregnancy will also cause abnormalities male offspring reproductive organs such as cryptorchidism. In this study, after administered pregnant mouse orally at dose 300 mg/kg body weight every day gestational (GD)12 GD18, can not only hypospadias but...
Background To explore the role of microvascular pathology in migraine, we investigated association between migraine and retinal damage. Methods We included 3270 participants (age ≥ 45 years, 63% women) from population-based Rotterdam Study (2006–2009). Participants with were identified using a validated questionnaire based on ICHD-II criteria (n = 562). Retinopathy signs graded fundus photographs. Retinal arteriolar venular caliber measured by semi-automatic assessment Associations...
Objective To investigate the association of migraine genetic variants with cerebral blood flow (CBF). Background Migraine is a common disorder many and non‐genetic factors affecting its occurrence. The exact pathophysiological mechanisms underlying disease remain unclear, but are known to involve hemodynamic vascular disruptions. Recent genome‐wide studies have identified 44 in 38 loci that affect risk migraine, which provide opportunity further disentangle these mechanisms. Methods We...
To study airway pathophysiology and the role of dendritic cells (DCs) IL-17 receptor (IL-17R) signals in a mouse model for CBD.Here, we present CBD which mice were exposed to beryllium during three weeks. We also IL-17R-deficient DCs depleted.Eight weeks after initial exposure, an inflammatory response was detected lungs. Mice displayed inflammation lower airways that included focal dense infiltrates, granuloma-like foci, tertiary lymphoid structure (TLS) containing T cells, B germinal...
<h3>Background</h3> Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these T-helper-17 (Th17) cells have been implicated to play a crucial role in the development and progression of chronic inflammation. Recently, authors found that active vitamin compound, 1,25(OH)<sub>2</sub>D<sub>3</sub>, direct both human mouse Th17 cytokine expression activity. Using gene-expression profiling, aim identify molecular targets...
Previous studies have not consistently found significant improvements in left ventricular ejection fraction or global longitudinal strain (GLS) after radiofrequency catheter ablation (RFCA) patients with pre-excitation. The aim of this study was thus to explore the effects RFCA on function pre-excitation using a new noninvasive echocardiographic method myocardial work.A total 34 who underwent and 18 healthy controls were prospectively included study. Before participants RFCA,...
Intrauterine exposure to flutamide not only causes abnormal development of the reproductive organs in male offspring, but also damages ovaries and uteri. The unfolded protein response (UPR) is believed play an important role embryo teratogenic processes. In present study, pregnant mice were administered either (300mg kg-1 day-1, p.o.) on equivalent volume soybean oil (control) Days 12-18 gestation. Eight weeks after birth, female offspring flutamide-treated group had a lower bodyweight...
<h3>Background and objectives</h3> CCR6+ T helper (Th) cells, including Th17 Th17.1 are thought to play an important role in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). They produce cytokines like IL-17A TNFα activate synovial fibroblasts induce a pro-inflammatory feedback loop. This interaction may underlie chronic joint inflammation RA therefore Th cells interesting therapeutic target this disease. Vitamin D is known have suppressive effects on its active...