A5100655902- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Policy and Management
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and Mental Health
- Acute Ischemic Stroke Management
- Primary Care and Health Outcomes
- Healthcare cost, quality, practices
- Disaster Response and Management
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Hospital Admissions and Outcomes
- Viral gastroenteritis research and epidemiology
- COVID-19 and healthcare impacts
- Animal Virus Infections Studies
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Medication Adherence and Compliance
- COVID-19 epidemiological studies
- Blood transfusion and management
- Emergency and Acute Care Studies
University at Albany, State University of New York
2013-2023
Peking Union Medical College Hospital
2023
Chinese Medical Association
2023
Lanzhou University
2023
Yangzhou University
2023
Guangzhou University of Chinese Medicine
2021
Ministry of Education of the People's Republic of China
2021
Wenzhou Medical University
2020
First Affiliated Hospital of Wenzhou Medical University
2020
Lanzhou Veterinary Research Institute
2019
Introduction: Healthcare workers (HCWs) were at the frontline during battle against Severe Acute Respiratory Syndrome (SARS). Understanding their fears and anxieties may hold lessons for handling future outbreaks, including acts of bioterrorism. Method: We measured risk perception impact on personal work life 15,025 HCWs from 9 major healthcare institutions SARS epidemic in Singapore using a self-administered questionnaire Impact Events Scale analyzed results with bivariate multivariate...
To develop a 30-day mortality risk index for noncardiac surgery that can be used to communicate information patients and guide clinical management at the "point-of-care," by surgeons hospitals internally audit their quality of care.Clinicians rely on Revised Cardiac Risk Index quantify cardiac complications in undergoing surgery. Because from causes accounts many perioperative deaths, there is also need simple bedside predict all-cause after surgery.Retrospective cohort study 298,772 during...
The 3C-like proteinase of severe acute respiratory syndrome (SARS) coronavirus has been proposed to be a key target for structural-based drug design against SARS. In order understand the active form and substrate specificity enzyme, we have cloned, expressed, purified SARS proteinase. Analytic gel filtration shows mixture monomer dimer at protein concentration 4 mg/ml mostly 0.2 mg/ml, which correspond used in enzyme assays. linear decrease enzymatic-specific activity with revealed that only...
To examine the hospital variability in use of red blood cells (RBCs), fresh-frozen plasma (FFP), and platelet transfusions patients undergoing major noncardiac surgery.Blood transfusion is commonly used surgical procedures United States. Little known about perioperative rates for surgery.We University HealthSystem Consortium database (2006-2010) to allogeneic RBC, FFP, surgery. We regression-based techniques quantify practices study association between characteristics likelihood...
Little is known as to whether long-term outcomes of acute ischemic stroke (AIS) vary by race/ethnicity. Using the American Heart Association Get With The Guidelines-Stroke registry linked with Medicare claims data set, we examined 30-day and 1-year differed race/ethnicity among older patients AIS.We analyzed 200 900 AIS >65 years age (170 694 non-Hispanic whites, 85.0%; 20 514 blacks, 10.2%; 6632 Hispanics, 3.3%; 3060 Asian Americans, 1.5%) from 926 US centers participating in program April...
Of the approximately four million women who give birth each year in United States, nearly 13 percent experience one or more major complications. But extent to which rates of obstetrical complications vary across hospitals States is unknown. We used multivariable logistic regression models examine variation complication outcomes US among a large, nationally representative sample than 750,000 deliveries 2010. found that 22.55 patients delivering vaginally at low-performing experienced...
Background: Singapore was affected by an outbreak of severe acute respiratory syndrome (SARS) from 25 February to 31 May 2003, with 238 probable cases and 33 deaths. Aims: To study usage personal protective equipment (PPE) among three groups healthcare workers (HCWs: doctors, nurses, administrative staff), determine if the appropriate PPE were used different examine factors that may inappropriate use. Methods: A self-administered questionnaire survey 14 554 HCWs in nine settings, which...
Objective To determine whether outcome disparities between black and white trauma patients have decreased over the last 10 years. Data Source Pennsylvania Trauma Outcome Study. Study Design We performed an observational cohort study on 191,887 admitted to 28 Level 1 II centers. The main outcomes of interest were (1) death, (2) death or major complication, (3) failure‐to‐rescue. Hospitals categorized according proportion patients. Multivariate regression models used estimate trends in racial...
Racial disparities in healthcare the United States are widespread and have been well documented. However, it is unknown whether racial exist use of blood transfusion for patients undergoing major surgery. We used University HealthSystem Consortium database (2009-2011) to examine perioperative red cells (RBCs) coronary artery bypass surgery (CABG), total hip replacement (THR), colectomy. estimated multivariable logistic regressions black more likely than white receive RBC transfusion,...
Abstract Federated learning (FL) as a distributed machine (ML) technique has lately attracted increasing attention of healthcare stakeholders FL is perceived promising decentralized approach to address data privacy and security concerns. The stores maintains the privacy-sensitive locally while allows multiple sites train ML models collaboratively. We aim describe most recent real-world cases using in both COVID-19 non-COVID-19 scenarios also highlight current limitations practical challenges FL.
Background Existing studies on cardiovascular diseases (CVDs) often focus individual‐level behavioral risk factors, but research examining social determinants is limited. This study applies a novel machine learning approach to identify the key predictors of county‐level care costs and prevalence CVDs (including atrial fibrillation, acute myocardial infarction, congestive heart failure, ischemic disease). Methods Results We applied extreme gradient boosting total 3137 counties. Data are from...
Asian-Americans represent an important United States minority population, yet there are limited data regarding the clinical care and outcomes of following acute myocardial infarction (AMI). Using from American Heart Association Get With The Guidelines-Coronary Artery Disease (GWTG-CAD) program, we compared use trends in evidence-based AMI processes outcome Asian-American versus white patients.We analyzed 107,403 patients (4412 Asian-Americans, 4.1%) 382 centers participating program between...
Background. Good decisions depend on an accurate understanding of the comparative effectiveness decision alternatives. The best way to convey data needed support these comparisons is unknown. Objective. To determine how well 5 commonly used presentation formats information. Methods. study was Internet survey using a factorial design. Participants consisted 279 members online panel. Study participants compared outcomes associated with 3 hypothetical screening test options relative possible...
Abstract The handheld ultrasound demonstrates clinical and economic value in combating COVID-19 based on interviews with frontline physician cardiologist as well a national expert medical ultrasound.
AbstractAbstract2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) isolated from the buds of Cleistocalyx operculatus, was investigated for its reversal effects on cancer cell multidrug resistance. DMC potentiated cytotoxicity chemotherapeutic agent doxorubicin to drug-resistant KB-A1 cells. When 5 μM present simultaneously with doxorubicin, IC50 DOX cells decreased 13.9 ± 0.7 μg/ml 3.6 μg/ml. A human carcinoma xenograft model established line. could sensitize tumors as indicated by a...
The Leapfrog Group reports on hospitals' adoption of the National Quality Forum Patient Safety Practices. However, it is unknown whether hospital compliance with these safe practices associated improved outcomes in patients undergoing major surgery.We analyzed association between mortality and Safe Practices among coronary artery bypass graft surgery (n=18,565), abdominal aortic aneurysm repair (n=2777), hip replacement (n=25,067) hospitals participating 2007 Hospital Survey using logistic...
Objective: To evaluate factors associated with 1-year mortality after discharge for acute stroke.Methods: In this retrospective cohort study, we studied 305 patients ischemic stroke or intracerebral hemorrhage discharged in 2010/2011. We linked Get With The Guidelines®-Stroke clinical data New York State administrative and used multivariate regression models to examine variables related all-cause poststroke.Results: mean age was 68.6 ± 14.8 years 51.1% were women. A total of 146 (47.9%)...
Little is known about the economic burden for ischemic stroke (IS) patients with atrial fibrillation (AF) in China.We aimed to compare of treatment-related costs IS AF vs. without China.This retrospective analysis used data from Beijing urban health insurance database. Using a random sampling method, 10% diagnosed 1 January through 31 December 2012 were enrolled. First hospitalization was considered as index event and hospital utilization after followed up until September 2013. Overall...
It is well established that clinical inertia generates suboptimal care in patients with chronic diseases, and policies interventions have yet to satisfactorily address the problem.This paper integrates relevant literatures on Regulatory Focus Theory (RFT) from psychology identify an actionable explanatory mechanism.We review RFT show it provides a mechanism may explain key provider contributions inertia. We then two general intervention strategies based RFT: one changes individual...