A5030774155- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinopathy of Prematurity Studies
- Health, Environment, Cognitive Aging
- Telomeres, Telomerase, and Senescence
- Helicobacter pylori-related gastroenterology studies
- Retinal Diseases and Treatments
- Gestational Diabetes Research and Management
- Cannabis and Cannabinoid Research
- Death Anxiety and Social Exclusion
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Urban Green Space and Health
- Urinary Tract Infections Management
- Dietary Effects on Health
- Alcohol Consumption and Health Effects
- Urban Heat Island Mitigation
- Cardiovascular Health and Risk Factors
- RNA modifications and cancer
- Religion, Spirituality, and Psychology
- Cancer-related molecular mechanisms research
- Reproductive tract infections research
- Pregnancy and preeclampsia studies
- Diabetes Treatment and Management
Northwestern University
2018-2024
University of Missouri
2023-2024
University of Missouri Hospital
2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2018-2022
National Heart Lung and Blood Institute
2020
Framingham Heart Study
2020
University of Illinois Chicago
2015-2018
Kansas City University
2012
Elevated intraocular pressure (IOP) is a significant risk factor for glaucoma, the leading cause of irreversible blindness worldwide. While previous studies have identified numerous genetic variants associated with IOP, these loci only explain fraction IOP heritability. Recently established biobank repositories resulted in large amounts data, enabling identification remaining heritability complex traits. Here, we describe largest genome-wide association study to date using participants...
[Figure: see text].
Adverse childhood experiences (ACEs) are associated with the risk of poorer health, and identifying molecular mechanisms may lay foundation for health promotion in people ACEs.
Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated association between 20-year greenness [Normalized Difference Vegetation Index (NDVI)] and a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for individual neighborhood socioeconomic characteristics, greater was slower aging. Black participants had...
Abstract Background The metabolic syndrome (MetS) is a collection of disturbances that can lead to various cardiovascular diseases. Previous studies have shown more adverse risk profile associated with advanced biological aging. associations between epigenetic biomarkers age MetS, however, are not well understood. We therefore investigated the acceleration and MetS severity score incident MetS. Results A subset study participants available whole blood at examination years 15 20 from Coronary...
Cardiovascular health (CVH) from young adulthood is strongly associated with an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining epigenomic biomarkers lifelong CVH exposure understanding their roles in CVD development may help develop preventive therapeutic strategies for CVD.
Aging | doi:10.18632/aging.204467. Drew R. Nannini, Brian T. Joyce, Yinan Zheng, Tao Gao, Jun Wang, Lei Liu, David Jacobs, Pamela J. Schreiner, Chunyu Qi Dai, Steve Horvath, Ake Lu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-Jones, Lifang Hou
Proximity to urban blue and green spaces has been associated with improved cardiovascular health; however, few studies have examined the role of race socioeconomic status in these associations.
Marijuana is a widely used psychoactive substance in the US and medical recreational legalization has risen over past decade. Despite growing number of individuals using marijuana, studies investigating association between epigenetic factors recent cumulative marijuana use remain limited. We therefore investigated DNA methylation levels. Participants from Coronary Artery Risk Development Young Adults Study with whole blood collected at examination years (Y) 15 Y20 were randomly selected to...
Abstract Background The two most common repetitive elements (REs) in humans, long interspersed nuclear element-1 (LINE-1) and Alu element (Alu), have been linked to various cancers. Hepatitis C virus (HCV) may cause hepatocellular carcinoma (HCC) by suppressing host defenses, through DNA methylation that controls the mobilization of REs. We aimed investigate role RE HCV-induced HCC (HCV-HCC). Results studied over 30,000 locus-specific REs across genome HCC, cirrhotic, healthy liver tissues...
Bacterial vaginosis (BV) affects 20% of women worldwide and is associated with adverse reproductive health outcomes increased risk for HIV. Typically, BV represents a shift in the vaginal microbiome from one that dominated by
The relationship of religiousness with the HEXACO (Honesty-Humility, Emotionality, Extraversion, Agreeableness, Conscientiousness, Openness) model personality was studied in Iran and United States. Correlations factors were generally similar across two societies. In both countries, associated higher scores on Honesty-Humility, Conscientiousness. Honesty-Humility factor one strongest correlates countries. These findings support Saroglou's observation that main characteristics are consistent...
The cornea is the outermost layer of eye and a vital component focusing incoming light on retina. Central corneal thickness (CCT) now recognized to have significant role in ocular health risk factor for various diseases, such as keratoconus primary open angle glaucoma. Most previous genetic studies utilized European Asian subjects identify loci associated with CCT. Minority populations, Latinos, may aid identifying additional improve our understanding architecture In this study, we conducted...
Background Existing studies on cardiovascular diseases (CVDs) often focus individual‐level behavioral risk factors, but research examining social determinants is limited. This study applies a novel machine learning approach to identify the key predictors of county‐level care costs and prevalence CVDs (including atrial fibrillation, acute myocardial infarction, congestive heart failure, ischemic disease). Methods Results We applied extreme gradient boosting total 3137 counties. Data are from...
The alcohol-associated biological aging remains to be studied across adulthood. We conducted linear regression analyses investigate the associations between alcohol consumption and two DNA methylation-based age acceleration metrics in 3823 Framingham Heart Study participants (24–92 years 53.8% women) adjusting for covariates. also investigated whether epigenetic mediated association of with hypertension. found that higher long-term average was significantly associated assessed by GrimAge...
Breast cancer is the most common diagnosed in women and often treated with chemotherapy. Although previous studies have demonstrated increasing biological age patients who receive chemotherapy, evaluation of this association DNA methylation-based markers ageing may provide novel insight into role chemotherapy on process. We therefore sought to investigate between as estimated from methylation breast cancer. profiling was performed peripheral blood collected 18 before after first cycle using...
Abstract Chronic lymphocytic leukemia (CLL) is a mature B cell neoplasm with predilection for older individuals. While previous studies have identified epigenetic signatures associated CLL, whether age-related DNA methylation changes modulate CLL relapse remains elusive. In this study, we examined the association between age acceleration and time to in publicly available dataset. profiling of 35 patients prior initiating chemoimmunotherapy was performed using Infinium HumanMethylation450...
This article reports cultural differences in the relationship between personality characteristics and euthanasia attitudes using samples from Iran United States. Survey data university students were analyzed multivariate regression. Results indicate that while toward are significantly more positive among U.S. sample, there is greater variation Iranian sample. Honesty-Humility Openness to Experience predictive factors both samples, where Agreeableness only significant group. Additionally,...
The variant V122I is commonly enriched in the transthyretin (TTR) gene individuals of African ancestry and associated with greater risk heart failure (HF) older adulthood, after age 65 years. Prevention HF may be most effective earlier life, but whether screening echocardiography can identify subclinical cardiac abnormalities during middle to risk-stratify appears unknown.
Inadequate pathology personnel and high cost of running a Pathology facility are factors affecting access to timely quality services in resource-constrained settings. Telepathology is novel technology that allows Pathologists remotely assess collected samples. Though the initial setting up telepathology high, its overall benefits far outweigh cost. Its usefulness as assurance measure, permanent image data storage system, reducing costs associated with repeated slide preparations, turn-around...
Researchers hypothesized that telomere shortening facilitates carcinogenesis. Previous studies found inconsistent associations between blood leukocyte length (LTL) and cancer. Epigenetic reprogramming of maintenance mechanisms may help explain this inconsistency. We examined DNA methylation in telomere-related genes (TRG) analyzed 475 participants providing 889 samples 1 to 3 times (median follow-up, 10.1 years) from 1999 2013 the Normative Aging Study. All were cancer-free at each visit...
Purpose: Vertical cup-disc ratio (VCDR) is used as a clinical assessment measure to identify and monitor glaucomatous damage the optic nerve. Previous genetic studies conducted in European Asian populations have identified many loci associated with VCDR. The factors other ethnic populations, such Latino, influencing VCDR remain be determined. Here, we describe first genome-wide association study (GWAS) on Latino individuals. Methods: We this GWAS using 4537 individuals who were genotyped by...
Abstract Background Marijuana is the third most commonly used drug in USA and efforts to legalize it for medical recreational use are growing. Despite increase use, marijuana’s effect on aging remains understudied understanding effects of marijuana molecular may provide novel insights into role process. We therefore sought investigate association between cumulative recent with epigenetic age acceleration (EAA) as estimated from blood DNA methylation. Results A random subset participants The...