A5005065036- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- COVID-19 Clinical Research Studies
- Advanced Radiotherapy Techniques
- Spine and Intervertebral Disc Pathology
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Cervical and Thoracic Myelopathy
- Cleft Lip and Palate Research
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Moyamoya disease diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- COVID-19 and healthcare impacts
- Neurofibromatosis and Schwannoma Cases
- Scoliosis diagnosis and treatment
- Retinal and Optic Conditions
- Cancer Risks and Factors
- Intracranial Aneurysms: Treatment and Complications
- FOXO transcription factor regulation
- Head and Neck Cancer Studies
Los Angeles Medical Center
2023-2024
Tulane University
2019-2022
Neurological Surgery
2021
Ochsner Medical Center
2020
Tulane Medical Center
2020
University of California, Los Angeles
2014-2016
Adipose stem cells (ASCs) play an essential role in tumor microenvironments. These are altered by obesity (obASCs) and previous studies have shown that obASCs secrete higher levels of leptin. Increased leptin, which upregulates estrogen receptor alpha (ERα) aromatase, enhances bioavailability signaling positive (ER⁺) breast cancer (BC) growth metastasis. In this study, we evaluate the effect on ER⁺BC outside ERα axis using models with constitutively active resulting from clinically relevant...
PurposeIn pediatric cancer survivors treated with whole-brain irradiation (WBI), long-term cognitive deficits and morbidity develop that are poorly understood for which there is no treatment. We describe similar defects in juvenile WBI rats correlate them alterations diffusion tensor imaging magnetic resonance spectroscopy (MRS) during brain development.Methods MaterialsJuvenile Fischer received clinically relevant fractionated doses of or a high-dose exposure. Diffusion MRS were performed...
BACKGROUND: Whole brain radiotherapy is a common for metastatic cancer. While it prolongs survival, causes transient early-delayed cognitive deficits termed “beamo” brain. We describe dose-escalation study that demonstrates potential preclinical animal model of this clinical phenomenon. METHODS: 3-month old Fisher rats were given single fraction 0, 10, 20, or 30G Gray (Gy) whole irradiation. The open-field exploration task and the elevated plus maze performed at 4 months post-irradiation....
BACKGROUND: Late effects of radiotherapy in survivors pediatric brain tumors are life-long and debilitating. We describe the behavior imaging characteristics a rat model given fractionated whole radiation equivalent to doses used treat children with high-risk medulloblastoma. METHODS: One month-old Fischer rats were 9 fractions either 0 or 3 Gray (Gy). A third group was eight 3Gy followed by single 10Gy “top off” serve as positive control. The 27Gy dose is biologically 36Gy children....