A5004249941- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Financial Reporting and Valuation Research
- Corporate Finance and Governance
- Economic Theory and Policy
- Herpesvirus Infections and Treatments
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Housing, Finance, and Neoliberalism
- HIV Research and Treatment
- Income, Poverty, and Inequality
- FOXO transcription factor regulation
- Tryptophan and brain disorders
- State Capitalism and Financial Governance
- Bone Tissue Engineering Materials
- European Political History Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Orthopaedic implants and arthroplasty
- Transportation and Mobility Innovations
- Auction Theory and Applications
- Congenital heart defects research
- Autophagy in Disease and Therapy
- Historical and Contemporary Political Dynamics
Tulane University
2018-2024
CFA Institute
2011-2017
University of Georgia
2008
University of Oxford
2000
University College London
2000
Wellcome Trust Centre for the History of Medicine
2000
Critical-sized bone defects fail to heal and often cause non-union. Standard treatments employ autologous grafting, which can donor tissue loss/pain. Although several scaffold types enhance regeneration, multiple factors limit their level of success. To address this issue, study evaluated a novel decellularized human adipose (DAT) hydrogel as an alternative. In study, DAT alone, or in combination with adipose-derived stromal/stem cells (ASC), osteo-induced ASCs (OIASC), hydroxyapatite were...
Risk factors contributing to dementia are multifactorial. Accumulating evidence suggests a role for pathogens as risk factors, but data is largely correlative with few causal relationships. Here, we demonstrate that intermittent murine cytomegalovirus (MCMV) infection of mice, alters blood brain barrier (BBB) permeability and metabolic pathways. Increased basal mitochondrial function observed in microvessels cells (BMV) exposed MCMV accompanied by elevated levels superoxide. Further, mice...
Adipose stem cells (ASCs) play an essential role in tumor microenvironments. These are altered by obesity (obASCs) and previous studies have shown that obASCs secrete higher levels of leptin. Increased leptin, which upregulates estrogen receptor alpha (ERα) aromatase, enhances bioavailability signaling positive (ER⁺) breast cancer (BC) growth metastasis. In this study, we evaluate the effect on ER⁺BC outside ERα axis using models with constitutively active resulting from clinically relevant...
Obesity is associated with poorer responses to chemo- and radiation therapy for breast cancer, which leads higher mortality rates obese women who develop cancer. Adipose stem cells (ASCs) are an integral stromal component of the tumor microenvironment (TME). In this study, effects obesity-altered ASCs (obASCs) on estrogen receptor positive cancer cell’s (ER+BCCs) response radiotherapy (RT) were evaluated. We determined that BCCs had a decreased apoptotic index increased surviving fraction...
Macrophages and microglia represent the primary phagocytes first line of defense in peripheral central immune systems. They activate polarize into a spectrum pro- anti-inflammatory phenotypes response to various stimuli. This activation is tightly regulated balance appropriate with tissue repair homeostasis. Disruption this results inflammatory disease states damage. Adipose stem cells (ASCs) have great therapeutic potential because potent immunomodulatory capabilities which induce...
Glioblastoma (GBM) is an aggressive primary central nervous system neoplasia with limited therapeutic options and poor prognosis. Following reports of cytomegalovirus (HCMV) in GBM tumors, the anti-viral drug Valganciclovir was administered found to significantly increase longevity patients. While these findings suggest a role for HCMV GBM, relationship between them not clear remains controversial. Treatment drugs may prove clinically useful; however, their results do explain underlying...
Human cytomegalovirus (HCMV) is a near ubiquitous herpesvirus that relies on host cell metabolism for efficient replication. Although it has been shown HCMV requires functional mitochondria replication, unknown whether mitochondrial targeted pharmacological agents can be repurposed as antivirals. Here we report treatment with drugs targeting the electron transport chain (ETC) complexes inhibit Addition of rotenone, oligomycin, antimycin and metformin resulted in decreased titers vitro,...
Human adipose-derived stem cells (hASCs) are potent modulators of inflammation and promising candidates for the treatment inflammatory autoimmune diseases. Strategies to improve hASC survival immunoregulation active areas investigation. Autophagy, a homeostatic stress-induced degradative pathway, plays crucial role in paracrine signaling-a primary mechanism therapeutic action. Therefore, induction autophagy with rapamycin (Rapa), or inhibition 3-methyladenine (3-MA), was examined as...
Human adipose-derived stem cells (ASCs) show immense promise for treating inflammatory diseases, attributed primarily to their potent paracrine signaling. Previous investigations demonstrated that short-term Rapamycin preconditioning of bone marrow-derived (BMSCs) elevated secretion prostaglandin E2, a pleiotropic molecule with therapeutic effects in the experimental autoimmune encephalomyelitis (EAE) model multiple sclerosis (MS), and enhanced immunosuppressive capacity vitro. However, this...
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