A5017515496- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Viral gastroenteritis research and epidemiology
- Axon Guidance and Neuronal Signaling
- Bacteriophages and microbial interactions
- Oral health in cancer treatment
- CAR-T cell therapy research
- Plant Parasitism and Resistance
- Cancer-related gene regulation
- Vibrio bacteria research studies
- Wnt/β-catenin signaling in development and cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Iron Metabolism and Disorders
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Plant Virus Research Studies
- Congenital heart defects research
- Legume Nitrogen Fixing Symbiosis
- RNA modifications and cancer
Stanford University
2018-2023
Lucile Packard Children's Hospital
2018-2019
Oregon Health & Science University
2009-2010
Highlights•Gut colonization precedes most mucosal barrier injury BSIs in HSCT recipients.•Antibiotics are associated with rising abundances of resistant strains the gut.•Detection vanA and ESBL genes predicts phenotypic resistance BSI strains.ABSTRACTThe gastrointestinal tract is predicted reservoir for bloodstream infections (BSIs) after hematopoietic stem cell transplantation (HSCT). Whole-genome sequencing comparative genomics have potential to improve our understanding dynamics gut that...
BACKGROUND. Gut decontamination (GD) can decrease the incidence and severity of acute graft-versus-host disease (aGVHD) in murine models allogeneic hematopoietic cell transplantation (HCT). In this pilot study, we examined impact GD on gut microbiome composition aGVHD HCT patients.
Microbial source tracking (MST) identifies sources of fecal contamination in the environment using host-associated markers. While there are numerous bacterial MST markers that can be used herein, few such viral Here, we designed and tested novel based on tomato brown rugose fruit virus (ToBRFV) genomes. We assembled eight nearly complete genomes ToBRFV from wastewater stool samples San Francisco Bay Area United States. Next, developed two probe-based reverse transcription-PCR (RT-PCR) assays...
Infections and graft-versus-host disease (GVHD) have historically resulted in high mortality among children undergoing umbilical cord blood transplantation (UCBT). However, recent advances clinical practice likely improved outcomes of these patients. We conducted a retrospective cohort study (<18years age) UCBT at Duke University between January 1, 1995 December 31, 2014. compared 2-year all-cause cause-specific during 3 time periods based on year (1995 to 2001, 2002 2007, 2008 2014). used...
Abstract Microbial source tracking (MST) identifies sources of fecal contamination in the environment using host-associated markers. While there are numerous bacterial MST markers, few viral Here we design and test novel markers based on tomato brown rugose fruit virus (ToBRFV) genomes. We assembled eight nearly complete genomes ToBRFV from wastewater stool samples San Francisco Bay Area United States America. Next, developed two probe-based RT-PCR assays conserved regions genome, tested...
Summary The microbiota influences intestinal health and physiology, yet the contributions of commensal protists to gut environment have been largely overlooked. Here, we identified several new rodent- human-associated parabasalid protists. Genomic metabolomic analyses murine parabasalids from genus Tritrichomonas revealed species-level differences in excretion metabolite succinate. This metabolic dissimilarity results distinct small immune responses during protist colonization. Metabolic...
ABSTRACT Background Gut decontamination (GD) can decrease the incidence and severity of acute graft- versus-host-disease (aGVHD) in murine models allogeneic hematopoietic cell transplantation (HCT). Several HCT centers standardly practice GD with different antibiotic regimens. In this pilot study, we examined impact on gut microbiome composition aGVHD patients. Methods We randomized 20 pediatric patients undergoing to receive or not (no-GD) oral vancomycin-polymyxin B from day -5 through...