A5035710786- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Dementia and Cognitive Impairment Research
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Geriatric Care and Nursing Homes
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Radiation Therapy and Dosimetry
- Lung Cancer Treatments and Mutations
- Retinal Imaging and Analysis
- Cancer survivorship and care
- Intergenerational Family Dynamics and Caregiving
- Cancer-related cognitive impairment studies
- Medication Adherence and Compliance
- Cancer Diagnosis and Treatment
- Family Support in Illness
- Gestational Trophoblastic Disease Studies
- Education, Healthcare and Sociology Research
University Health Network
2022-2025
Princess Margaret Cancer Centre
2022-2025
Baycrest Hospital
2019-2025
Sylvester Comprehensive Cancer Center
2024
University of Toronto
2017-2024
University of Miami
2024
Public Health Ontario
2017-2018
ObjectivesThe onset of the COVID-19 pandemic significantly challenged capacity long-term care (LTC) homes in Canada, resulting new, pressing priorities for leaders and health providers (HCPs) safety LTC residents. This study aimed to determine whether Project ECHO (Extension Community Healthcare Outcomes) Care Elderly Long-Term (COE-LTC): COVID-19, a virtual education program, was effective at delivering just-in-time learning best practices support teams residents during pandemic.DesignMixed...
To evaluate 18F-DCFPyL-PET/MRI whole-gland-derived radiomics for detecting clinically significant (cs) prostate cancer (PCa) and predicting metastasis. Therapy-naïve PCa patients who underwent 18F-DCFPyL PET/MRI were included. Whole-prostate-segmentation was performed. Feature extraction from each modality done. The selection of potential variables made through regularized binomial logistic regression. oversampled training data used to train regression outcome. estimates the models...
PurposeThe capacity for machine learning (ML) to facilitate radiotherapy (RT) planning primary brain tumors has not been described. We evaluated ML-assisted RT with regards clinical acceptability, dosimetric outcomes and efficiency adults children tumours.Methods MaterialsIn this prospective study, receiving 54 Gy fractionated a tumor were enrolled. For each patient, one plan was created compared or two plans using standard ("manual") procedures. Plans by the treating oncologist, who blinded...
This study assessed agreement between an automated spectral-domain optical coherence tomography (SD-OCT) retinal segmentation software and manually corrected to validate its use in a prospective clinical of neurodegenerative diseases (NDD).The sample comprised 30 subjects with NDD, including vascular cognitive impairment, frontotemporal dementia, Parkinson's disease, Alzheimer's disease. Macular SD-OCT scans were acquired segmented using Heidelberg Spectralis. For the central foveal B scan...
Abstract Background Grade Group 1 (GG1) prostate cancer should be managed with active surveillance (AS). Global uptake of AS remains disappointingly slow and heterogeneous. Removal labels has been proposed to reduce GG1 overtreatment. We sought determine the impact disease terminology on individual’s perceptions decision making. Methods Discrete choice experiments were conducted 3 cohorts: healthy men, canonical partners (partners), patients (patients). Participants reported preferences in a...
BackgroundPolypharmacy is prevalent in long-term care homes (LTCH) and increases the risk of adverse drug events. Feasible effective deprescribing interventions applicable LTCH environment are needed. MethodsWe performed a mixed methods study to evaluate feasi-bility, applicability, effectiveness an electronic depre-scribing tool, MedSafer, facilitate quarterly medication reviews (QMRs) on two pilot units academic home (LTCH). Chart collected resident health data. The prevalence at standard...
Integrated magnetic resonance linear accelerator (MR-Linac) systems offer potential for biologically based adaptive radiation therapy using apparent diffusion coefficient (ADC). Accurate tracking of longitudinal ADC changes is key to establishing ADC-driven dose adaptation. Here, we report repeatability and reproducibility intraprostatic deformable image registration (DIR) correct inter-fraction prostate changes.
For young adults (YAs) with cancer, connecting peer cancer survivors can provide a unique sense of community and may enhance post-traumatic growth (PTG). This study examined the relationship between connectedness to YA PTG among YAs, independent overall social support.
Our purpose was to prospectively assess the distribution of NETPET scores in well-differentiated (WD) grade 2 and 3 gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) determine impact score on clinical management.
Hearing loss is the largest potentially modifiable risk factor for dementia and highly prevalent among older adults, yet it goes largely unreported, unidentified, untreated, at great cost to health quality of life. screening a proven cost-effective solution overcome delays in its identification management not typically recommended by physicians adults.To demonstrate feasibility value hearing adults order enhance physicians' awareness improve access timely care.Patients referred two academic...
Targeted screening programs for patients at high risk anal squamous-cell carcinoma have been proposed; however, the evidence in support of remains unclear.This study aimed to determine whether high-risk (predominantly those living with HIV) detected an earlier stage compared routine practice not screening.This is a cohort study.This was conducted quaternary care center Canada.Included were least 18 years old pathologic diagnosis invasive between 2002 and 2022.Patients diagnosed through...
Background Prostate-specific membrane antigen (PSMA) PET is useful in the early detection of oligorecurrent prostate cancer (PCa), but whether PSMA parameters can be used to identify patients who would benefit from metastasis-directed therapy (MDT) with radiation or surgery remains uncertain. Purpose To assess association outcomes PCa after MDT. Materials and Methods In this retrospective analysis a single-center phase II trial that enrolled biochemical recurrence maximal local no evidence...
Older adults are entering long-term care (LTC) homes with more complex needs than in previous decades, resulting demands on point-of-care staff to provide additional and specialty services. This study evaluated whether Project ECHO® (Extension for Community Healthcare Outcomes) Care of the Elderly Long-Term (COE-LTC)-a case-based online education program-is an effective capacity-building program among interprofessional health-care teams caring LTC residents.A mixed-method, pre-and-post...
Background: Therapeutic lying is an intervention used by health care professionals (HCPs) when a person with dementia disoriented and distressed all other interventions have not succeeded in deescalating the symptoms of dementia. Method: The goal this study was to evaluate workshop on therapeutic for HCPs specializing persons living Seventeen HPCs, including nurses personal support workers (PSWs), participated evaluation survey. Results: did affect attitudes toward dementia, their sense...
The presence of ectoparasites in animals creates a multitude health risks to both the host and humans who come contact with these animals. This study aims conduct an ectoparasite survey among those quarantined wildlife rescue center determine distribution their hosts. Acetate strip technique manual extraction methods were employed collect from brought center. About 53% positive for ectoparasitic infestation. A total 344 recovered 51 birds 6 mammals Of ectoparasites, 23 are lice 321 mites....
A model of a virtual psychotherapeutic support group was developed for young-onset dementia (YOD; people with under the age 65) caregivers; one adult children and spouses. This pilot study evaluated impact groups on YOD caregivers’ psychosocial well-being, coping abilities, knowledge. At post, measures revealed an increase in number strategies rated as helpful among 13 spousal 14 caregivers who completed study. Adult were observed to have reduction both negative caregiving depression scores....
521 Background: Macrovascular invasion (MVI) in hepatocellular carcinoma (HCC) patients is a poor prognostic factor. Current guidelines endorse systemic therapy for MVI. Local therapies present potential obliteration of MVI and improved survival. Surgery has been the standard local at our institution, stereotactic body radiotherapy (SBRT) emerged as an alternative this patient population. Methods: In retrospective study, one-to-one optimal pair propensity score matching was used to compare...
<title>Abstract</title> <underline><bold>Background</bold></underline> Breast cancer (BC) is the second most common etiology of brain metastases (BrM). We aimed to examine incidence BrM among all BC patients presenting a large tertiary centre over one decade. <underline><bold>Methods</bold></underline> included consecutively between 2009 and 2019 cross referenced that cohort radiotherapy database, identifying treated for at any time following their initial presentation. Cumulative incidences...
Project Extension for Community Healthcare Outcomes (ECHO) enables healthcare providers to share knowledge and best practices via telementoring. The ECHO model builds provider capacity improves care patients with a variety of health conditions. This study describes Canada-wide National pilot project in the area geriatric mental reports on program's impact providers' practices. A mixed-methods approach was used analyze surveys completed by participating providers. Program evaluation measured...