A5081679824- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Evolutionary Psychology and Human Behavior
- Medical Imaging and Analysis
- Social and Intergroup Psychology
- Cell Image Analysis Techniques
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Psychology of Moral and Emotional Judgment
- Single-cell and spatial transcriptomics
- Cardiac Imaging and Diagnostics
- Dementia and Cognitive Impairment Research
- Electroconvulsive Therapy Studies
- Advanced Fluorescence Microscopy Techniques
- Treatment of Major Depression
German Center for Neurodegenerative Diseases
2024-2025
University of Bonn
2024
University Hospital Bonn
2021-2023
Structural MRI often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly early stages. To improve its utility, we aimed to identify optimal readouts for different use cases. We included 363 older adults; healthy controls (HC) who were negative or positive amyloid-beta (Aβ) Aβ-positive patients with subjective cognitive decline (SCD), mild impairment, dementia of the Alzheimer type. neuropsychological assessments administered annually up three years....
Possible interactions of the neuropeptide oxytocin and sex hormone estradiol may contribute to previously observed sex-specific effects on resting-state functional connectivity (rsFC) amygdala hippocampus. Therefore, we used a placebo-controlled, randomized, parallel-group magnetic resonance imaging study design measured hippocampus rsFC in healthy men (n = 116) free-cycling women 111), who received gel (2 mg) or placebo before intranasal administration (24 IU) placebo. Our results reveal...
Considerable evidence supports sex differences in episodic memory. The hormones estradiol and oxytocin both affect memory may contribute to these differences, but possible underlying hormonal interactions have not been tested a sample involving sexes. To this end, we conducted randomized, placebo-controlled, parallel-group functional magnetic resonance imaging (fMRI) study including healthy free-cycling women (n = 111) men 115). fMRI session was under four experimental conditions: 1....
Abstract Alzheimer’s disease (AD) is a major cause of dementia and cognitive decline. Here we assessed how episodic memory circuit dysfunction, hallmark AD, related to the longitudinal cascade AD biomarkers, neurodegeneration cognition using data from DZNE Longitudinal Cognitive Impairment Dementia study. This set unique by including over 1000 functional magnetic resonance imaging (fMRI) measurements during encoding. We leveraged progression model (DPM) obtain scores. Voxel-wise analyses...
Abstract This study introduces the Structural MRI-based Alzheimer’s Disease Score (SMAS), a novel index intended to quantify (AD)-related morphometric patterns using deep learning Bayesian-supervised Variational Autoencoder (Bayesian-SVAE). SMAS was constructed baseline structural MRI data from DELCODE and evaluated longitudinally in two independent cohorts: DEL-CODE (n=415) ADNI (n=190). Our findings indicate that has strong associations with cognitive performance (DELCODE: r=-0.83; ADNI:...
Abstract High-dimensional cytometry (HDC) is a powerful technology for studying single-cell phenotypes in complex biological systems. Although technological developments and affordability have made HDC broadly available recent years, advances were not coupled with an adequate development of analytical methods that can take full advantage the data generated. While several platforms bioinformatics tools become analysis data, these are either web-hosted limited scalability or designed expert...
Considerable evidence supports sex differences in episodic memory, which may translate to heightened vulnerability stress- and trauma-related disorders women. The hormones estradiol oxytocin both affect but possible underlying hormonal interactions have not been systemically tested humans. To this end, healthy women (n = 111) men 115) received gel (2 mg) or placebo before the administration of intranasal (24 IU) a randomized, placebo-controlled, parallel-group functional magnetic resonance...