A5089370410- Innovative Human-Technology Interaction
- Interactive and Immersive Displays
- Marine Bivalve and Aquaculture Studies
- Multimedia Communication and Technology
- Cancer Cells and Metastasis
- Digital Games and Media
- Cancer survivorship and care
- Family Support in Illness
- CAR-T cell therapy research
- Smoking Behavior and Cessation
- Cancer Immunotherapy and Biomarkers
- Bioinformatics and Genomic Networks
- Aquaculture Nutrition and Growth
- Childhood Cancer Survivors' Quality of Life
- Technology Use by Older Adults
- Personal Information Management and User Behavior
- Mental Health Research Topics
- Palliative Care and End-of-Life Issues
- Data Visualization and Analytics
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Usability and User Interface Design
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Aquaculture disease management and microbiota
Roslin Institute
2016-2024
University of Edinburgh
2016-2024
Microsoft Research (United Kingdom)
2010-2020
University of Newcastle Australia
2012-2019
Hunter New England Local Health District
2016-2019
Community Food Bank
2019
Hunter Medical Research Institute
2015-2018
Lakeland Regional Medical Center
2014-2016
Regional Health
2016
Microsoft (United States)
2005-2015
BackgroundPeripheral inflammation is often associated with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus investigation.MethodsWe used microarray data on whole blood from two independent case-control studies MDD: the GlaxoSmithKline–High-Throughput Disease-specific target Identification Program [GSK-HiTDiP] study (113 patients 57 healthy control subjects) Janssen–Brain Resource Company (94 100 subjects). Genome-wide differential gene expression...
Abstract The immune composition of the tumor microenvironment regulates processes including angiogenesis, metastasis, and response to drugs or immunotherapy. To facilitate characterization component tumors from transcriptomics data, a number cell transcriptome signatures have been reported that are made up lists marker genes indicative presence given population. majority these gene defined through analysis isolated blood cells. However, cells do not reflect differentiation activation state...
We describe the design, implementation and deployment of Photobox, a domestic technology that prints four or five randomly selected photos from owner's Flickr collection at random intervals each month. deployed Photobox in three homes for fourteen months, to explore how slow pace which it operates could support experiences anticipation re-visitation past. Findings reveal changes attitude toward device, frustration eventual acceptance. Participants drew on reflect past life events reactions...
We present findings from a year-long engagement with street and its community. The work explores how the production use of data is bound up place, both in terms physical social geography. detail three strands project. First, we consider residents have sought to curate existing about form an archive digital components. Second, report endeavours capture street's environment, especially vehicle traffic. Third, draw on possibilities afforded by technologies for polling opinion. reflect these...
We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r macrophage differentiation, there was a loss peripheral blood monocytes, microglia brain, epidermal Langerhans cells, splenic marginal zone macrophages, bone-associated macrophages and osteoclasts, peritoneal macrophages. Macrophages red pulp, liver, lung, gut were less affected. The pleiotropic impacts on development multiple organ systems distinct from those reported...
<h3>Importance</h3> The mechanisms by which engagement with internet-delivered psychological interventions are associated depression and anxiety symptoms unclear. <h3>Objective</h3> To identify behavior types based on how people engage an internet-based cognitive behavioral therapy (iCBT) intervention for of anxiety. <h3>Design, Setting, Participants</h3> Deidentified data 54 604 adult patients assigned to the Space From Depression Anxiety treatment program from January 31, 2015, March 2019,...
This is a protocol for Cochrane Review (Intervention). The objectives are as follows: To assess the effects of interventions medical students that aim to improve interpersonal communication in consultations.
Listeria monocytogenes is a Gram-positive bacterium that can cause septicemia and meningitis. TLRs are central receptors of the innate immune system drive inflammatory responses to invading microbes such as L. monocytogenes. Although intestinal epithelial cells (IECs) represent initial point entry used by for infection, response in these has been poorly characterized date. The aim this study was determine which involved mediating IECs. We performed an RNA interference screen 1-10 HT-29 IEC...
We present Project Zanzibar: a flexible mat that can locate, uniquely identify and communicate with tangible objects placed on its surface, as well sense user's touch hover hand gestures. describe the underlying technical contributions: efficient localised Near Field Communication (NFC) over large surface area; object tracking combining NFC signal strength capacitive footprint detection, manufacturing techniques for rollable device form-factor enables portability, while providing sizable...
Graphia is an open-source platform created for the graph-based analysis of huge amounts quantitative and qualitative data currently being generated from study genomes, genes, proteins metabolites cells. Core to Graphia’s functionality support calculation correlation matrices any tabular matrix continuous or discrete values, whereupon software designed rapidly visualise often very large graphs that result in 2D 3D space. Following graph construction, extensive range measurement algorithms,...
Abstract Introduction and Aims. Understanding how tobacco, alcohol mental health are related is important for developing population‐level policies individual‐level treatments that target comorbidities. The current study aimed to examine sociodemographic characteristics comorbidities associated with the odds of using tobacco harmful levels concurrently. Design Methods. Data were drawn from 45 U p S tudy, a large cohort 267 153 adults aged years over in N ew outh W ales, A ustralia....
Abstract The set of proteins required for mitotic division remains poorly characterized. Here, an extensive series correlation analyses human and mouse transcriptomics data were performed to identify genes strongly reproducibly associated with cells undergoing S/G2-M phases the cell cycle. In so doing, 701 cycle-associated defined while it was shown that many are only expressed during these phases, expression others is also driven by alternative promoters. Of this list, 496 have known cycle...
We describe the design and implementation of Photobox, a device intended to be used over many years, which occasionally prints randomly selected photo from owner's Flickr collection inside wooden chest. reflect on how engaging in this slow technology [5] led some unexpected challenges provoked us re-think approaches making technologies that are long time scales might act infrequently. also living with during phase insights. conclude implications for research practice space.
The European honey bee (Apis mellifera) plays a major role in pollination and food production. Honey health is complex product of the environment, host genetics associated microbes (commensal, opportunistic pathogenic). Improved understanding these factors will help manage modern challenges to health. Here we used DNA sequencing characterise genomes metagenomes 19 colonies from across Britain. Low heterozygosity was observed many Scottish which had high similarity native dark bee. Colonies...
Genome editing is transforming bioscience research, but its application to non-model organisms, such as farmed animal species, requires optimisation. Salmonids are the most important aquaculture species by value, and improving genetic resistance infectious disease a major goal. However, use of genome evaluate putative genes in cell lines, genome-wide CRISPR screens currently limited lack available tools techniques.
Abstract While the UK is fourth largest aquaculture producer in Europe by volume, it second value with an annual first sale of around £1 billion. Over 90% this from Atlantic salmon farmed Scotland, but other finfish and shellfish species are important to several regions. In review, we describe state art breeding stock supply, how innovation genetics technologies can help achieve Scottish Government’s ambitious target doubling its industry 2030. Particular attention given four most species:...