A5100332883- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Invertebrate Immune Response Mechanisms
- Immune Response and Inflammation
- Iron Metabolism and Disorders
- Aquaculture Nutrition and Growth
- interferon and immune responses
- Toxoplasma gondii Research Studies
- Immune Cell Function and Interaction
- Neurological Disorders and Treatments
- Animal Virus Infections Studies
- Trace Elements in Health
- Immune cells in cancer
- Child Nutrition and Water Access
- T-cell and B-cell Immunology
- Stroke Rehabilitation and Recovery
- Marine Sponges and Natural Products
- Hemostasis and retained surgical items
- HIV Research and Treatment
- Glaucoma and retinal disorders
- Surgical Sutures and Adhesives
- Cancer Mechanisms and Therapy
- Veterinary Orthopedics and Neurology
- Phytochemical compounds biological activities
- Fish biology, ecology, and behavior
Sichuan University
2025
Chengdu University
2025
Feed Research Institute
2022-2025
Chinese Academy of Agricultural Sciences
2018-2025
Lishui University
2018-2025
Ministry of Agriculture and Rural Affairs
2022-2024
Florida State University
2024
Soochow University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking University
2024
The N-lobe of human serum transferrin (hTF/2N) has been expressed in baby hamster kidney cells and crystallized both orthorhombic (P212121) tetragonal (P41212) space groups. Both crystal forms diffract to high resolution (1.6 1.8 A, respectively) have solved by molecular replacement. Subsequent refinement resulted final models for the structure hTF/2N that had crystallographic R-factors 18.1 19.7% two forms, respectively; these represent highest-resolution structures determined date....
Probiotics as green inputs have been reported to regulate metabolism and immunity of fish. However, the mechanisms by which probiotics improve growth health fish are unclear. Therefore, aim this study was investigate effect Bacillus subtilis HGCC-1, an indigenous probiotic isolated from fish, on performance, host lipid metabolism, liver inflammation gut microbiota golden pompano. 160,000 pompanos with initial body weight 93.6 ± 5.0 g randomly assigned two dietary groups: Control HGCC-1...
Background & AimsThe liver is an organ with paradoxic immunologic properties and known for its tolerant microenvironment, which holds important implications hepatic diseases. The molecular basis this local immune suppression, however, poorly understood. In study, we aimed to determine the role of sinusoidal endothelial cell lectin (LSECtin), a recently identified member dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) family, in regulation T-cell response.MethodsThe effector...
Abstract Background The liver-expressed antimicrobial peptide 2 (LEAP2) is essential in host immunity against harmful pathogens and only known to act as an extracellular modulator regulate embryonic development amphibians. However, there a dearth of information on the function amphibian LEAP2. Hence, LEAP2 homologue from Leptobrachium liui was identified, characterized, chemically synthesized, its antibacterial activities mechanisms were determined. Results In this study, gene ( Ll-LEAP2 )...
Staphylococcus aureus is one of the most common pathogens that colonizes human skin/mucous membranes, where it causes local infection can progress to invasive infection, resulting in high morbidity and mortality worldwide. This study aimed investigate antibiotic susceptibility molecular characteristics S. children women Southwest China from 2018 2023 provide novel insights helpful preventing treating infections. The demographic clinical patients with were collected analyzed. Next-generation...
Abstract Background The liver-expressed antimicrobial peptide 2 (LEAP2) family is an important group of peptides (AMPs) involved in vertebrate defence against bacterial infections. However, research on LEAP2 amphibians still its infancy. Results This study aimed to explore the role Chinese spiny frog ( Quasipaa spinosa ). cDNA gene QsLEAP2 ) was cloned from a frog. protein comprises signal peptide, prodomain, and mature peptide. Sequence analysis indicated that member amphibian cluster...
Several hemostatic strategies rely on the use of blood components such as fibrinogen and thrombin, which suffer from high cost short shelf‐life. Here, a cost‐effective synthetic biomaterial is developed for rapid local hemostasis. Instead using thrombin‐receptor‐agonist‐peptide‐6 (TRAP6) covalently engineered in polyvinyl alcohol (PVA) hydrogels. Soluble PVA‐TRAP6 first prepared by covalent attachment cysteine‐containing TRAP6 onto backbone PVA‐norbornenes (PVA‐NB) through photoconjugation....
To seek evidence of a primitive adaptive immune system (AIS) before vertebrate, we examined whether lymphocytes or lymphocyte-like cells and the related molecules participating in lymphocyte function existed amphioxus. Anatomical analysis by electron microscopy revealed presence gills, these underwent morphological changes response to microbial pathogens that are reminiscent those mammalian executing challenge. In addition, systematic comparative our cDNA database amphioxus identified large...
Abstract Background The liver-expressed antimicrobial peptide 2 (LEAP2) plays a pivotal role in the host’s immune response against pathogenic microorganisms. Numerous such peptides have recently been shown to mitigate infection risk fish, and studying those harboured by economically important fish Acrossocheilus fasciatus is imperative for enhancing its responses In this study, we cloned sequenced LEAP2 cDNA from A. examine expression tissues investigate structure–activity relationships of...
Liver-expressed antimicrobial peptide 2 (LEAP-2) is a cationic that plays an important role in host’s innate immune system. We previously demonstrated mudskipper (<i>Boleophthalmus pectinirostris</i>) LEAP-2 (BpLEAP-2) induces chemotaxis and activation of monocytes/ macrophages (MO/MФ). However, the molecular mechanism by which BpLEAP-2 regulates MO/MΦ remains unclear. In this study, we used yeast two-hybrid cDNA library screening to identify protein(s) interacted with BpLEAP-2,...
This study investigated the effects of Lactobacillus rhamnosus fermentation products added to feed on common carp (Cyprinus carpio) growth, gut and liver health, microbiota. Common with an average weight 1.95±0.4 g were fed five experimental diets: normal diet (normal) supplemented (abbreviation: 0.2% GCC-3, 0.3% 0.4% GCC-3 0.5% respectively) for 8 weeks. The results showed that product did not affect growth phenotype carp. significantly reduced serum alanine aminotransferase (ALT) aspartate...
Abstract Background Esculentin-1, initially discovered in the skin secretions of pool frogs ( Pelophylax lessonae ), has demonstrated broad-spectrum antimicrobial activity; however, its immunomodulatory properties have received little attention. Results In present study, esculentin-1 cDNA was identified by analysing transcriptome dark-spotted frog nigromaculatus ). Esculentin-1 from this species (esculentin-1PN) encompasses a signal peptide, an acidic spacer and mature peptide. Sequence...
and