Background: Myopia is a condition in which the visual images come to focus front of retina eye. This disease major cause disability, presents 108 million persons globally. Purpose: study aims determine relationship between degree myopia, axial length, and choroidal thickness (CT). Methods: an observational analytical that made use cross-sectional design. A total 59 participants with refractive errors underwent treatment at Hasanuddin University Hospital 116 eyes were measured analyzed. The...

Abstract. Savitri AP, Massi MN, Hatta M, Santoso A, Fachri Djaharuddin I, Wahyuni S, Ilyas Iskandar H, Pattelongi Handayani IW, Hidayah N, Angria Halik H. 2025. Analysis of miR-21-5p and miR-144-5p expression as biomarkers in active lung tuberculosis home contacts. Biodiversitas 26: 831-836. Considering the central role microRNAs (miRNAs) development disease, researchers have proposed that specific circulating miRNAs affect outcome (TB) infection blood miRNA levels might reflect course...

Host response to polytrauma occasionally has unpredictable outcomes. Immune is a major factor influencing patient's outcome. This study evaluated the interaction of two main cytokines in immune after trauma, specifically interleukin-6 (IL-6) and interleukin-10 (IL-10). Plasma level these determined by mRNA expression genes which may decide outcome patients.This prospective multicenter trial held at four trauma centers enrolled 54 patients [Injury Severity Score (ISS) ≥ 16]. levels IL-6 IL-10...

Introduction: Benign prostatic hyperplasia (BPH) is a histopathological diagnosis characterized by the increase in stromal cells and epithelial of prostate gland transitional zone surrounding urethra.Obesity risk factor BPH.The most frequent cause obesity high-fat diet (HFD).Obesity HFD lead to pro-inflammatory conditions.One pathomechanisms for occurrence BPH low-degree inflammatory factor, one which level monocyte chemoattractant protein-1/MCP-1.This study aims determine influence on...

BackgroundNew cases of hepatitis B virus (HBV) infection continue to occur worldwide. Most these are due mother-to-child transmission (MTCT), with maternal viraemia as the most important contributing factor. The surface antigen (HBsAg) level, which correlates positively viral load, has been used for treatment monitoring in chronic B. This study evaluated usefulness quantitative HBsAg load prediction HBsAg-positive pregnant women.MethodsA total 943 women Makassar, Indonesia, were screened...

Around 70% of breast cancers (BCs) are estrogen receptor-α (ERα)-positive. Adjuvant endocrine therapy is used to reduce levels and inhibit signal transduction through the ER. The anti-estrogen drugs that most commonly in belong selective ER modulator (SERM) class include tamoxifen. Although it has been for three decades cases early-stage ERα-positive BC, resistance tamoxifen a common problem. microRNAs (miRNAs) have potential role demonstrating BC therapy. Hence, there need investigate...

The formation of a scar after Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccination influences the effectiveness protection against tuberculosis (MTB) infection. innate immunity plays critical role both in pathophysiology (TB) and BCG mechanism. Parts immunity: macrophages, dendritic cells, neutrophils, have microbial recognition surface receptors called Toll-like (TLR) 2 4. objective this study is to compare serum levels TLR2 TLR4 BCG-vaccinated pediatric patients with pulmonary...

Objective: Glioma is one of the most frequent and disabling primary brain tumour. Patients are not only dealing with survival, but also quality life, which remains another major concern. Karnofsky Performance Scale (KPS) commonly used scale to assess patients' life. A recent scale, known as Neurological Assessment Neuro-Oncology Scale, has surfaced examine neurological disability caused by Previous study showed this be superior KPS in predicting survival. However, these scales have never...

The ability of Mycobacterium tuberculosis to survive intracellularly, provides a cellular adaptive immune response played by specific T cells defend against tuberculosis. Bacillus Calmette and Guerin (BCG) immunization is responded B cells, Follicular helper, regulatory, restriction CD1, CD8+, CD4+, Th1, Th2, Th17. BCG can cause tuberculin test reaction being positive. method for diagnosing TB infection screening individuals latent assessing the rate in given population.a nested case-control...

Tuberculosis infection causes a complex immunological response, where interactions between the pathogen and host are unique, making it difficult to treat control this disease. According WHO, an estimated 1 million children became ill with TB, 233,000 died of TB in 2017. Bacillus Calmette-Guérin (BCG) vaccines continue be only prevent (TB). Studies suggesting association BCG scar decreased childhood mortality developing countries have rekindled interest scar. However, direct effect remains...

Tuberculosis (TB) remains a major global health problem, in the top 10 causes of death. As regulator immune response, T-helper (Th) cells activate other lymphocytes from system, such as B cells, to destroy TB pathogen by releasing CD4 and CD8 Th cells. Diabetes mellitus (DM) is known cause developing active pulmonary TB. Few studies have examined biomolecular expression affecting Mycobacterium tuberculosis (MTB) multidrug-resistant (MDR) MTB, which are associated with low immunity...

Background: Miana (Coleus scutellariodes (L) Benth) are a herbal medicine with potential anti-inflammatory properties in patients infected vulvovaginal candidiasis. The objective of this work was to the analyze IL-37 expression following administration miana leaf extract (MLE) an animal model Material and Methods: Adult Balb/c mice, aged 8–12 weeks weighing 30–40 g, were divided into five groups. Four groups administered Candida albicans via intravaginal inoculation diluted dose 10-2/ ml...

BACKGROUND: Visceral Obesity is related with chronic low grade inflammation, and the main component of metabolic syndrome (MetS). MetS associated increased cardiovascular disease (CVD). Furthermore, superoxide dismutase (SOD) correlated insulin resistance. Several studies have reported a strong correlation between Renin Angiotensin Aldosterone System (RAAS) CVD, but association Aldosterone, Plasma Activity (PRA) SOD resistance not been fully elucidated. The aim this study was to investigate...

Hydroquinone, which is considered the gold standard skin depigmenting agent, has been associated with multiple side effects. Lately, deoxyarbutin suggested to be an alternative of hydroquinone better safety profile.To compare effect 2% and 4% sera.This double-blind randomized controlled study was done on right left arms healthy participants. Subjects were instructed apply either or serum each arm, randomly labeled as group A B, every day for 12 weeks. Chromameter mexameter analysis 2 weeks...

The immune system can produce various inflammatory mediators to protect the body from stress and surgical trauma. However, this excessive response will interfere with body's system, causing systemic syndrome multi-organ failure if allowed continue. Lidocaine as an anti-inflammatory is used treat pain arising disease process ventricular arrhythmias. This study aims prove efficacy of lidocaine injection drug in BALB/c mice sterile musculoskeletal injuries.

The high mortality rate in breast cancer (BC) patients is generally due to metastases resistant systemic therapy. Two causes of therapy resistance BC are circulating miRNAs-221 and miR-222, leading improved cell proliferation, survival, reduced apoptosis. This study investigated the miRNA expression changes associated with tamoxifen expected be clinically meaningful before providing endocrine luminal-type who express them.

Surgical site infection (SSI) is a devastating complication in orthopedic surgery. Methicillin-resistant Staphylococcus aureus (MRSA) notorious organism SSI, especially patients. We aimed to understand the association between MRSA carriers and rate of SSI caused by

Tuberculosis (TB) is still a major global health problem. The increasing prevalence of antibiotic resistance has posed threat towards the mission TB eradication. Traditional medication been staple alternative and adjuvant to conventional treatment for Indonesians. Miana leaves (Coleus scutellariodes) one such traditional medicine that potential role as immunoregulator, antiinflammation, antimicrobial agent. Several studies have shown extract can regulate TLR 4, number CD4 T cells, IFN-γ...

Objective To provide a detailed description of characteristics at hospital admission and clinical outcomes 30-day 6-month follow-up in patients hospitalised with coronary artery disease (CAD) poor South-East Asian setting. Design Prospective observational cohort study. Setting From February 2013 to December 2014, Makassar Cardiac Center, Indonesia. Participants 477 CAD (acute syndrome stable CAD). Outcome measures All-cause mortality major adverse cardiovascular events (MACE). Results Out...

Researches on the effects of High Fat Diet (HFD) decreased renal function with cystatin C (cysC) serum levels biomarker are few and show different findings. Renin Angiotensin System (RAS) plays a key role in controlling one integral components RAS is Converting Enzyme 2 (ACE2). Research relationship between plasma ACE2 cysC animals induced by HFD has not been done. We hypothesize that administration can cause decline early stage through ACE2. 30 male wistar rats aged 10-12 weeks (body weight...

Cycling is a physical exercise that widely performed to improve fitness. Regular will lead adaptations exercise. This adaptation useful in suppressing the production of reactive oxygen stress (ROS) generated response cellular metabolism uses oxygen. Transforming growth factor beta-1 (TGF-β1) plays role increasing ROS, thus, when concentration low, it would an improvement study aims compare levels TGF-β1 between recreational cyclists and sedentary groups. In addition, this research also...