A5016994282- Thyroid Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Pancreatic and Hepatic Oncology Research
- Ion channel regulation and function
- Pediatric Hepatobiliary Diseases and Treatments
- Epilepsy research and treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Thyroid and Parathyroid Surgery
- Lung Cancer Research Studies
- Gallbladder and Bile Duct Disorders
- Vascular Tumors and Angiosarcomas
- Pituitary Gland Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Neuroblastoma Research and Treatments
- Cancer-related Molecular Pathways
- Colorectal Cancer Screening and Detection
- Head and Neck Anomalies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Lesions and Carcinomas
- Protein Degradation and Inhibitors
- Meta-analysis and systematic reviews
- Phenothiazines and Benzothiazines Synthesis and Activities
Memorial Sloan Kettering Cancer Center
2021-2025
Georgetown University
2020-2024
MedStar Georgetown University Hospital
2020-2024
Kettering University
2022
MedStar Washington Hospital Center
2020-2021
University of Virginia Health System
2010-2019
University of Virginia
2010
Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor (NET) arising from the calcitonin-producing C cells. Unlike other NETs, there no widely accepted pathologic grading scheme. In 2020, two groups separately developed slightly different schemes (the Memorial Sloan Kettering Cancer Center and Sydney grade) on basis of proliferative activity (mitotic index and/or Ki67 index) necrosis. Building this work, we sought to unify validate internationally scheme for MTC.Tumor tissue...
During epileptogenesis a series of molecular and cellular events occur, culminating in an increase neuronal excitability, leading to seizure initiation. The entorhinal cortex has been implicated the generation epileptic seizures both humans animal models temporal lobe epilepsy. This hyperexcitability is due, part, proexcitatory changes ion channel activity. Sodium channels play important role controlling alterations their activity could facilitate We sought investigate whether medial (mEC)...
Purpose: The prognostic importance of RET and RAS mutations their relationship to clinicopathologic parameters outcomes in medullary thyroid carcinoma (MTC) need be clarified.
Aims Recently, there have been attempts to improve prognostication and therefore better guide treatment for patients with medullary thyroid carcinoma (MTC). In 2022, the International MTC Grading System (IMTCGS) was developed validated using a multi‐institutional cohort of 327 patients. The aim current study build upon findings IMTCGS develop validate prognostic nomogram predict recurrence‐free survival (RFS) in MTC. Methods Results Data from 300 five centres across USA, Europe, Australia...
Background: Tumor grade is a new validated prognostic factor for medullary thyroid cancer (MTC). Calcitonin doubling time can predict MTC recurrence. We aimed to describe the association of tumor with calcitonin and its effect on disease-specific outcomes times after resection. Methods: A retrospective analysis patients who underwent resection at single tertiary-care center between 1986 2017 were evaluated. Tumors designated as high-grade if two head neck pathologists identified mitotic...
Jejunal diverticula are a rare subtype of false found in the gastrointestinal tract. When present, they usually multiple, proximal jejunum and asymptomatic. Rarely, can cause acute complications that develop into an abdomen requiring surgical intervention. We present manifestation single jejunal diverticulum causing midgut volvulus bowel ischemia. Early intervention with small derotation allowed complete recovery. Data regarding case, operative intervention, patient follow-up was...