A5100780646- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- RNA modifications and cancer
- Plant-based Medicinal Research
- Antiplatelet Therapy and Cardiovascular Diseases
- ATP Synthase and ATPases Research
- Angiogenesis and VEGF in Cancer
- Cardiovascular Function and Risk Factors
- Kruppel-like factors research
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Meningioma and schwannoma management
- Viral Infections and Immunology Research
- Plant Toxicity and Pharmacological Properties
- Circular RNAs in diseases
- Phytochemical Studies and Bioactivities
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Connective Tissue Growth Factor Research
- Renin-Angiotensin System Studies
- Coenzyme Q10 studies and effects
First Affiliated Hospital of Henan University
2018-2023
First Affiliated Hospital of Zhengzhou University
2022
Shanghai Ninth People's Hospital
2017-2021
Weatherford College
2021
Shanghai Jiao Tong University
2017-2020
Henan University of Traditional Chinese Medicine
2012-2020
Shanxi University
2019
Anyang Hospital of Traditional Chinese Medicine
2011
Henan Provincial People's Hospital
2011
Zhengzhou City Hospital
2010
Clivorine is a representative naturally occurring hepatotoxic otonecine-type pyrrolizidine alkaloid. Our previous study has demonstrated that clivorine induces liver damage via metabolic activation to form the reactive pyrrolic ester followed by covalent binding tissue constituents. The present investigated species differences in vitro of male rat and guinea pig both sexes. In rat, was found as only pathway. Moreover, toxic tissue-bound pyrroles four isolatable metabolites identified, namely...
Background: Fibronectin 1 (FN1) is involved in cell adhesion and migration processes such as metastasis, wound healing, embryogenesis, blood coagulation, host defense. However, the role of FN1 diagnosis prognosis head neck squamous carcinoma (HNSCC) far from understood. Methods: expression profiles clinical parameters multiple HNSCC datasets were applied to evaluate association between survival. We also identified mRNA protein levels 20 pairs samples by quantitative polymerase chain reaction...
Radioresistance remains a major problem in the treatment of patients with hypopharyngeal squamous cell carcinoma (HSCC). Long noncoding RNAs (lncRNAs) have important roles development, invasion, and metastasis various tumors, including HSCC, but little is known about role lncRNAs cancer radioresistance. The aim this study was to identify radioresistance-related mRNAs radioresistant (RS) subclone RS-FaDu cells. In study, we performed microarray analysis find differences time-course lncRNA...
Flavonoids are important secondary metabolites synthesized by the tea plant. However, inconsistencies in variations gene annotation methods across numerous studies, have hindered comparisons of results from previous studies. In this work, we offer 'GFAnno', an open-source software package annotates genes and families based on sequence features, along with annotated parameters for 18 key related to flavonoid biosynthesis pathway. The takes a protein file as input, performs identity coverage...
To observe the effects of Xuesetong Soft Capsules (, Notoginseng total saponin) on angiogenesis and vascular endothelial growth factor (VEGF) mRNA expression in ischemic myocardium rats with myocardial infarction. The left coronary artery was ligated to establish animal model acute Rats were randomly divided into Capsule, Shexiangbaoxin Pill (positive control), (negative control) sham operation groups. After 6 weeks, microvessel count (MVC), density (MVD) VEGF evaluated. MVC MVD infarct...
Radioresistance is a vital obstacle for the prognosis of human nasopharyngeal carcinoma (NPC), but underlying mechanism still unknown. Here, we explored role NRF2/KEAP1 pathway in radioresistance NPC cell lines.We selected lines CNE-1 and CNE-2, treated them with ionization, subsequently determined levels NRF2, KEAP1, antioxidant enzymes, ROS. We then evaluated effect NRF2 or KEAP1 inhibition on proliferation, colony formation, radiosensitivity CNE2 cells.We discovered that signaling can be...
DNA methylation and miRNA-target genes play an important part in the early development of various tumors have been studied as tumor biomarkers. Although previous studies reported a cluster molecular events (such aberrant alterations genomics epigenetics), little is known potential biomarkers for diagnosis prognostic evaluation head neck squamous cell carcinoma (HNSCC).Multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database clinical samples were applied to evaluate...
The Yiqi-Huoxue granule (YQHX) is a traditional Chinese medication widely used in the therapy of medicine diagnosis “Qi deficiency” or “blood stasis” China. Both these symptoms are related to inflammation, but mechanisms YQHX against inflammation largely unknown. Thus, our present study investigated effects on regulating inflammatory responses induced by lipopolysaccharides (LPS) HUVECs. Our data found that remarkably inhibits production prothrombotic factors, plasminogen activator...
YiqiHuoxue decoction (YHD) is frequently prescribed to prevent and treat cardiovascular diseases. YHD inhibits platelet aggregation, however the underlying mechanisms are unclear.The in vitro vivo anti-platelet antithrombotic effects of ethanol-precipitated (EYHD) were investigated. Forty-six Sprague-Dawley (SD) rats 36 male Kunming mice examined. Ten SD used assess cytotoxicity EYHD by releasing lactate dehydrogenase from treated platelets. The remaining divided into six groups (six per...
Atherosclerosis (AS) is one of the main causes cardiovascular disease. AS plaques often occur in blood vessels with oscillatory flow and their formation can be regulated by microRNAs (miRNAs). The aim this study to identify key miRNAs molecular pathways involved pathological process.In study, gene chip data obtained from GEO database was analyzed using LIMMA package find differentially expressed (DE miRNAs) carotid arteries ApoE-/- mice exposed different rates. Predicted targets DE were...
To observe the effects of Lüfukang Capsules on arrhythmia induced by ligation coronary artery in dogs.Thirty dogs were randomly divided into 5 groups, model group administrated with equal volume distilled water, positive control Wenxin Granules, and small, medium large dosage LFKC 6 each group. Thirty minutes after medication, electrocardiogram was conducted time occurrence, times ventricular premature beat (VP), incidence rates tachycardia (VT) fibrillation (VF) recorded artery.Compared...