A5101492946- Spinal Fractures and Fixation Techniques
- Sarcoma Diagnosis and Treatment
- Multimodal Machine Learning Applications
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Glaucoma and retinal disorders
- Bone Tumor Diagnosis and Treatments
- Retinal Diseases and Treatments
- Tumors and Oncological Cases
- Pelvic and Acetabular Injuries
- Endoplasmic Reticulum Stress and Disease
- Bone fractures and treatments
- Speech and dialogue systems
- Metalloenzymes and iron-sulfur proteins
- Robotics and Sensor-Based Localization
- Corneal surgery and disorders
- Musculoskeletal synovial abnormalities and treatments
- Advanced Image and Video Retrieval Techniques
- Hemoglobinopathies and Related Disorders
- Robot Manipulation and Learning
- Domain Adaptation and Few-Shot Learning
- Vascular Tumors and Angiosarcomas
- Monoclonal and Polyclonal Antibodies Research
Southeast University
2024
China Medical University
2011-2024
China Medical University Hospital
2011-2024
South China Agricultural University
2024
KK Women's and Children's Hospital
2018-2023
Center for Systems Biology
2023
Shanghai Jiao Tong University
2022-2023
Rutgers, The State University of New Jersey
2023
Guangdong Medical College
2019-2021
Shantou University Medical College
2021
Modulating the behaviors of reactive astrocytes is a potential therapeutic strategy for neurodegenerative diseases. We found that upregulation and activation epidermal growth factor receptor (EGFR) occur in after different injuries optic nerves vivo . Activation EGFR regulates genes cellular processes representing most major markers related with glaucomatous neuropathy other neural disorders. These results suggest common, regulatory pathway triggers quiescent into response to nerve, perhaps...
BackgroundAlthough the statement that age is greatest risk factor for Age-related macular degeneration (AMD) widely accepted, cellular and molecular explanations clinical are not generally known. A major focus of AMD research retinal pigment epithelium (RPE)/choroid. The purpose this study was to characterize changes in RPE/choroid with may provide a background development AMD.Methodology/Principal FindingsWe compared transcriptional profiles, key protein levels histology from young old...
Iron accumulation with age in the retinal pigment epithelium (RPE) may be one important source of oxidative stress that contributes to age-related macular degeneration (AMD). Young and old rodent RPE/choroid were compared assess iron homeostasis during normal aging effects increased on functions epithelial cells.The level, mRNA expression, protein level iron-regulatory molecules quantitatively between young animals. To test intracellular cells, vitro ARPE-19 cells treated high levels...
Patients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies bind DNA the GluN2A GluN2B subunits of N-methyl-d-aspartate receptor (NMDAR), termed DNRAbs, displayed a selective impairment spatial recall. Neural recordings mouse model SLE, which circulating DNRAbs penetrate hippocampus, revealed CA1 place cells exhibited significant expansion...
PurposeTo compare the effectiveness and safety of MicroShunt (Santen Inc., Emeryville, CA, USA) versus trabeculectomy in patients with primary open-angle glaucoma (POAG).DesignProspective, randomized, multicenter trial conducted United States Europe.ParticipantsAdult (aged 40-85 years) mild to severe POAG inadequately controlled on maximum tolerated medical therapy intraocular pressure (IOP) ≥15 mmHg ≤40 mmHg.MethodsPatients were randomized 3:1 standalone implantation (n=395) or (n=132),...
Abstract Sirtuin 2 (SIRT2) is an NAD+ dependent deacetylase that the most abundant sirtuin protein in brain. Accumulating evidence revealed role of SIRT2 a wide range biological processes and age‐related diseases. However, pivotal mechanism played Alzheimer's disease (AD) remains unknown. Here, we report pharmacological inactivation has beneficial effect AD. The inhibitor rescued cognitive impairment amyloid precursor protein/presenilin 1 transgenic mouse ( APP / PS1 mouse), BACE1 cleavage...
Purpose: The purpose of this study was to determine the efficacy suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi), in prevention excessive wound healing and scar formation rabbit model glaucoma filtration surgery (GFS). Methods: A GFS used. Rabbits that underwent received balanced salt solution, or SAHA (50 μM), mitomycin C (0.02%). Clinical scores IOP, bleb vascularity, slit-lamp examination were performed. On postoperative day 14, rabbits killed tissues...
It is a rather practical but difficult task to find specified target object via autonomous exploration based on natural language descriptions in an unstructured environment. Since the human-annotated data expensive gather for goal-oriented vision-language navigation (GVLN) task, size of standard dataset inadequate, which has significantly limited accuracy previous techniques. In this work, we aim improve robustness and generalization navigator by dynamically providing high-quality...
Retractor placement is a leading cause of intraoperative nerve injury during total hip replacement (THR) surgery. The sciatic nerve, femoral and superior gluteal are most commonly affected. This study aimed to identify the distances from bony landmarks in adjacent nerves on magnetic resonance imaging (MRI) associations between anatomical factors these that would guide retractors THR surgery, order minimize risk injury. We reviewed MRIs 263 adults recorded (1) anterior acetabular rim nerve;...
Aims Congenital mesoblastic nephroma (CMN) is histologically classified into classic, cellular and mixed subtypes. The aims of this study were to characterise the clinical, pathological molecular features a series CMNs, determine utility pan‐Trk epidermal growth factor receptor (EGFR) immunohistochemistry as surrogate markers for NTRK gene fusions EGFR internal tandem duplications (ITDs). Methods results Twenty‐two archival CMN cases (12 five cellular, mixed) tested ETV6 – NTRK3 fusion ITD...
Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly correct geometry enzyme. Here, we examined folding mechanism PAD4 and Ca2+ ions pathway. Multiple mutations were introduced into calcium-binding sites, these mutants termed Ca1_site, Ca2_site, Ca3_site, Ca4_site Ca5_site mutants. data indicate during unfolding process, dimer first dissociates monomers, monomers then undergo three-state...
The sulfur assimilation pathway is a key metabolic system in prokaryotes that required for production of cysteine and cofactors such as coenzyme A. In the first step pathway, APS reductase catalyzes reduction adenosine 5'-phosphosulfate (APS) to 5'-phosphate (AMP) sulfite with reducing equivalents from protein cofactor, thioredoxin. primary sequence distinguished by conserved iron−sulfur cluster motif, -CC-X∼80-CXXC-. Of motifs are associated 4Fe-4S centers, dyad atypical has generated...
Increasing evidence has indicated that single nucleotide polymorphisms (SNPs) are related to the susceptibility of sepsis and might provide potential for mechanisms sepsis. Our recent preliminary study showed ADAM10 genetic polymorphism was clinically associated with development sepsis, little is known about underlying mechanism. The aim this confirm association between promoter rs653765 G→A progression discover Clinical data positively correlated as evidenced by a multiple-center...
6D object pose estimation is a longstanding computer vision problem. Existing deep learning-based methods have achieved inspiring results in this task. However, large-scale training data with annotations extremely needed to guarantee these methods' performance, and acquiring real fairly labor-intensive time-consuming. To overcome drawback, we propose semi-supervised method using labeled synthetic unlabeled data. For data, form self-supervised pipeline by minimizing the distance between input...
Abstract Background Xp10 and OP1 are phages of Xanthomonas oryzae pv. (Xoo), the causative agent bacterial leaf blight in rice plants, which were isolated 1967 Taiwan 1954 Japan, respectively. We recently Xoo phage Xop411. Results The linear Xop411 genome (44,520 bp, 58 ORFs) sequenced here is 147 bp longer than that (60 735 (59 ORFs). G+C contents (51%) (52% each) less host (65%). 9-bp 3'-overhangs (5'-GGACAGTCT-3') absent from OP1. More deduced proteins share higher degrees identity with...