A5058551149- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Electrospun Nanofibers in Biomedical Applications
- Pulmonary Hypertension Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cardiovascular Issues in Pregnancy
- Vascular anomalies and interventions
- Cardiac and Coronary Surgery Techniques
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Infectious Aortic and Vascular Conditions
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Aortic aneurysm repair treatments
- Pharmaceutical studies and practices
- Surgical Sutures and Adhesives
- Collagen: Extraction and Characterization
- Orthopaedic implants and arthroplasty
General University Hospital in Prague
2013-2024
Charles University
2013-2023
Centrum kardiovaskulární a transplantační chirurgie
2003-2022
University of Bristol
2022
Budd-Chiari syndrome (BCS) is a rare disease with an incidence of 0.1 to 10 per million inhabitants year caused by impaired venous outflow from the liver mostly at level hepatic veins and inferior vena cava. Etiological factors include hypercoagulable conditions, myeloprolipherative diseases, anatomical variability cava, environmental conditions. Survival rates in treated patients range 42 100% depending on etiology presence risk including parameters Child-Pugh score, sodium creatinine...
The aim of the study was to develop an orthopedic implant coating in form vancomycin-loaded collagen/hydroxyapatite layers (COLHA+V) that combine ability prevent bone infection with promote enhanced osseointegration. investigated employing a rat model simulated clinically relevant implant-related introduction bacterial contamination during surgical procedure using clinical isolate Staphylococcus epidermidis. enhance osseointegration minipig terminated growth. Six weeks following...
Adrenaline-producing tumors are mostly characterized by a sudden release of catecholamines with episodic symptoms. Noradrenergic ones usually less symptomatic and continuous overproduction that released into the bloodstream. Their effects on cardiovascular system can thus be different. The aim this study was to determine prevalence complications catecholamine phenotype.
Extracorporeal membrane oxygenation (ECMO) is an established tool for respiratory and circulatory support. In computed tomography, altered hemodynamics in ECMO patients requires special considerations handling contrast injection its timing. this article, we demonstrate changes captured on contrast-enhanced CT examinations pitfalls strategies relation to the flow, cardiac function placement of cannulas. Contrast-enhanced with prior knowledge cannulas, central venous lines, induced by low...
Our study presents a novel collagen wound dressing prepared from freshwater fish skin ( Cyprinus Carpio) type I. Half of the sponges were cross-linked with carbodiimide. The and non-cross-linked subsequently impregnated gentamicin lyophilized thus allowing for attainment appropriate content without removal thereof during cross-linking stage. structure was evaluated via micro-CT infrared spectrometry structural stability release properties in phosphate buffer solution. further tested rat...
Lymphatic transport of drugs after oral administration is an important mechanism for absorption highly lipophilic compounds. Direct measurement in lymph duct cannulated animals the gold standard method, but non-invasive cycloheximide chylomicron flow blocking method has gained popularity recently. However, concerns about its reliability have been raised. The aim this work was to investigate validity evaluation lymphatic using model compounds with high very lipophilicity, that is, abiraterone...
Aim . To assess the systemic and local immunological response to subcutaneous implants of a vascular graft covered with collagen extracted from European carp (freshwater fish) or bovine origin. Methods Pieces by pure (Bos taurus, BOV, n=14) (Cyprinus carpio, CYP, 5 mm in size were implanted subcutaneously dorsum Balb/cOla mice. A sham operation group 12 animals served as control. At 7 14 days after operation, one-half each was terminated blood for serum, spleen, implant surrounding tissue...
Aim . The aim of this study was to evaluate short-term patency the new prosthetic graft and its structural changes after explantation. Methods team developed a three-layer conduit composed scaffold made from polyester coated with collagen inner outer side an internal diameter 6 mm. implanted as bilateral bypass carotid artery in 7 sheep stenosis created selected animals. After period 161 days, explants were evaluated gross microscopic specimens. Results initial flow rate (median ± IQR)...
The study presents a novel vancomycin-releasing collagen wound dressing derived from Cyprinus carpio type I cross-linked with carbodiimide which retarded the degradation rate and increased stability of sponge. Following lyophilization, dressings were subjected to gamma sterilization. structure was evaluated via scanning electron microscopy images, micro-computed tomography, infrared spectrometry. structural vancomycin release properties in phosphate buffered saline. Microbiological testing...
The geometric shape of the distal anastomosis in an infrainguinal bypass has influence on its durability. In this article, we compared three different angles with regard to hemodynamics. Three experimental models 25°, 45°, and 60° respectively were constructed according similarity theory assess flow anastomoses using particle image velocimetry computational fluid dynamics. toe, heel, floor that correspond locations worst affected by intimal hyperplasia, adverse blood wall shear stress...
Abstract Background Cerebral perfusion may change depending on arterial cannulation site and affect the incidence of neurologic adverse events in post-cardiotomy extracorporeal life support (ECLS). The current study compares patients' outcomes with three commonly used strategies (aortic vs. subclavian/axillary femoral artery) to evaluate if each ECLS configuration is associated different rates complications. Methods This retrospective, multicenter (34 centers), observational included adults...
Aim: To highlight an optimal collaborative strategy of three different levels specialized care cardiac centres. Background: Refractory cardiogenic shock is a life-threatening condition. A myocardial recovery not achieved in many cases despite all efforts and subsequently the heart transplantation remains ultimate option. Thereby, use extracorporeal membrane oxygenation (ECMO) followed by ventricular assist device staged bridging provides attractive approach. Case report: We report on...
Hemodynamics in the distal end-to-side anastomosis is related to early development of intimal hyperplasia and bypass failure. In this study we investigated effect diameter ratios between target artery at three different angles connection. The pulsatile flow field was visualized using particle image velocimetry transparent models with connection (25°, 45°, 60°) ratio 4.6 mm : 6 mm, 7.5 mm. Six parameters including location oscillation stagnation point, local energy dissipation, wall shear...
Chronic thromboembolic pulmonary hypertension (CTEPH) in indicated cases can be successfully cured by endartectomy of arteries (PEA). Symptomatic nontreated CTEPH has a very poor prognosis; the five-year survival rate patients with medium pressure over 50 mmHg main artery is as low 10 %. This kind operation was previously not available Czech Republic. In 2004, PEA programme launched at Cardiocentre General Teaching Hospital Prague co-operation institution well known specialist this field...
Severe pulmonary hemorrhage in the newborn is an infrequent, but life-threatening, event. A with persistent hypertension and a large ductus arteriosus open foramen ovale presented hypoxemia progressive right heart failure shortly after birth, requiring veno-arterial extracorporeal membrane oxygenation (ECMO) support. Twenty minutes initiation of ECMO, patient developed severe refractory to conventional treatment. As last resort, endotracheal tube was clamped. After transport ECMO center,...
Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed explore pharmacokinetics adult patients and propose an easy applicable nomogram for initial treatment.Vancomycin was calculated a two-compartmental model based on therapeutic drug monitoring data. A linear regression used relationship between elimination half-life glomerular filtration rate estimated according Chronic Kidney Disease Epidemiology...
Surgical wounds resulting from biofilm-producing microorganisms represent a major healthcare problem that requires new and innovative treatment methods. Rifampin is one of small number antibiotics able to penetrate such biofilms, its local administration has the potential serve as an ideal surgical site infection protection and/or agent. This paper presents two types (homogeneous sandwich structured) rifampin-releasing carbodiimide-cross-linked fresh water fish collagen wound dressings.The...