A5008810310- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Advanced Proteomics Techniques and Applications
- RNA and protein synthesis mechanisms
- Neuroendocrine regulation and behavior
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Genomics and Chromatin Dynamics
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
Seoul National University Hospital
2013-2023
George Washington University
2020
Seoul National University
2008-2019
Despite the explosion in numbers of cancer genomic studies, metastasis is still major cause mortality. In breast cancer, approximately one-fifth metastatic patients survive 5 years. Therefore, detecting at a high risk developing distant first diagnosis critical for effective treatment strategy. We hereby present novel systems biology approach to identify driver mutations escalating based on both exome and RNA sequencing our collected 78 normal-paired cancers. Unlike occurring commonly...
Prediction of the responses to neoadjuvant chemotherapy (NACT) can improve treatment patients with advanced breast cancer. Genes and proteins predictive chemoresistance have been extensively studied in cancer tissues. However, noninvasive serum biomarkers capable such prediction rarely exploited. Here, we performed profiling N-glycosylated from fifteen (ten sensitive five resistant NACT) discover using a label-free liquid chromatography-tandem MS method. By performing series statistical...
This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone function in a model heart failure. Intranasal administration patients mimics short-term changes seen animals by increasing parasympathetic—and decreasing sympathetic—cardiac activity. provides essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) neuron...
// Kyung-Min Lee 1, 2 , Minju Jiwoo Sung Wuk Kim 4 Hyeong-Gon Moon 2, 3 Dong-Young Noh Wonshik Han 1 Biomedical Research Institute, Seoul National University Hospital, 110-744, Republic of Korea Cancer College Medicine, Department Surgery, Hanall Biopharma Co., Ltd., 138-922, Correspondence to: Han, e-mail: hanw@snu.ac.kr Keywords: metformin analog, breast cancer, stem cell population, G2/M arrest, anti-cancer drug Received: September 06, 2015 Accepted: May 05,...
Background Cancer stem cells (CSCs) are highly tumorigenic and responsible for tumor progression chemoresistance. Noninvasive imaging methods the visualization of CSC populations within tumors in vivo will have a considerable impact on development new CSC-targeting therapeutics. Methodology/Principal Findings In this study, human breast cancer (BCSCs) transduced with dual reporter genes (human ferritin heavy chain [FTH] enhanced green fluorescence protein [EGFP]) were transplanted into...
Abstract Background Chemotherapy is the standard treatment for breast cancer; however, response to chemotherapy disappointingly low. Here, we investigated alternative therapeutic efficacy of novel combination with necroptosis-inducing small molecules overcome chemotherapeutic resistance in tyrosine aminoacyl-tRNA synthetase (YARS)-positive cancer. Methods Pre-chemotherapeutic needle biopsy 143 invasive ductal carcinomas undergoing same regimen was subjected proteomic analysis. Four different...
Krukovine (KV) is an alkaloid isolated from the bark of Abuta grandifolia (Mart.) Sandw. (Menispermaceae) with anticancer potential in some cancers KRAS mutations. In this study, we explored efficacy and mechanism KV oxaliplatin-resistant pancreatic cancer cells patient-derived organoids (PDPCOs) mutation. After treatment KV, mRNA protein levels were determined by RNA-seq Western blotting, respectively. Cell proliferation, migration, invasion measured MTT, scratch wound healing assay,...
The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact human cell line MCF-7.MCF-7 and MDA-MB-231 were treated with anti-rabbit polyclonal IgG or anti-human rabbit antibodies to induce cross-linking, then growth was studied. Changes in characteristics such as cycle modulation, death, survival three-dimensional cultures, adhesion, migration ability assayed after MCF-7.Expression analyzed by flow cytometry MCF-7 where...
CD44 is a transmembrane glycoprotein that can regulate the oncogenic process. This known to be marker of claudin-low subtype breast cancer, as well cancer stem cell marker. However, its functional regulatory roles are poorly understood in cancer. To gain comprehensive insight into function CD44, we performed an in-depth tandem mass tag-based proteomic analysis two lines (MDA-MB-231 and Hs 578T) transfected with siRNA. As result, observed 2736 proteins were upregulated 2172 downregulated...
Jee-Hyung Lee, Jin Ho Choi, Kyung-Min Min Woo Ja-Lok Ku, Dong-Chan Oh, Yern-Hyerk Shin, Dae Hyun Kim, In Rae Cho, Paik, Ji Kon Ryu, Yong-Tae Sang Hyub Lee and Kook Lee. Biomolecules & Therapeutics 2024;32:123-35. https://doi.org/10.4062/biomolther.2023.109
A relatively low response to chemotherapy has been reported for hormone receptor (HR)-positive breast cancer. In this study, we investigated the role of tryptophanyl-transfer RNA synthetase (WARS) in chemotherapeutic HR-positive cancer.Pre-chemotherapeutic needle biopsy samples 45 cancer patients undergoing same regimen were subjected immunohistochemistry. To investigate biological functions WARS cancer, conducted cell viability assay, flow cytometry analysis, caspase activity Quantitative...
We investigated the expression of N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue estimated its clinicopathologic significance as a prognostic factor. The levels NMI were also analyzed according to molecular subgroup breast cancers.