A5026394498- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Marine Bivalve and Aquaculture Studies
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Mosquito-borne diseases and control
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Environmental Toxicology and Ecotoxicology
- Insect symbiosis and bacterial influences
- Viral Infections and Vectors
- Marine Biology and Environmental Chemistry
- Insect and Pesticide Research
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Ocean Acidification Effects and Responses
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Microplastics and Plastic Pollution
- Genetic factors in colorectal cancer
- Lung Cancer Diagnosis and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Insect behavior and control techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
Istituto Superiore di Sanità
2022-2025
University of Padua
2020-2025
Istituto Ramazzini
2015-2025
University of Palermo
2025
Sapienza University of Rome
2020-2024
Ospedale di Mirano
2023
Boehringer Ingelheim (United States)
2022
ET International (United States)
2022
ORCID
2022
University of Siena
2018-2021
// Alessandro Passardi 1, * , Emanuela Scarpi 2, Luigi Cavanna 3 Monia Dall'Agata 2 Davide Tassinari 4 Silvana Leo 5 Ilaria Bernardini 6 Fabio Gelsomino 7 Stefano Tamberi 8 Alba A. Brandes 9 Elena Tenti 10 Roberto Vespignani 11 Giovanni L. Frassineti 1 Dino Amadori Ugo De Giorgi Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy Unit Biostatistics and Clinical Trials, IRST Oncology Unit, Guglielmo da Saliceto...
There is growing concern for the wide use ofperfluorooctanoic acid (PFOA) because of its toxic effects on environment and human health. A new compound - so called C6O4 (perfluoro ([5-methoxy-1,3-dioxolan-4-yl]oxy) acetic acid) was recently introduced as one alternative to traditional PFOA, however this done without any scientific evidence when dispersed into environment. Recently, Regional Agency Protection Environment Veneto (Italy) detected high levels in groundwater Po river, increasing...
Contaminants of emerging concern and ocean changes are key environmental stressors for marine species with possibly synergistic, but still unexplored, deleterious effects. In the present study influence a simulated acidification scenario (pH = 7.6) was investigated on metabolism sub-lethal effects carbamazepine, CBZ (1 µg/L), chosen as one most widely diffused pharmaceuticals in organisms. A multidisciplinary approach applied mussels, M. galloprovincialis, integrating measurement drug...
The frequency of locally transmitted dengue virus (DENV) infections has increased in Europe recent years, facilitated by the invasive mosquito species Aedes albopictus, which is well established a large area Europe. In Italy, first indigenous outbreak was reported August 2020 with 11 acquired cases Veneto region (northeast Italy), caused DENV-1 viral strain closely related to previously described circulating Singapore and China. this study, we evaluated vector competence two Italian...
Background Toscana virus (TOSV) is transmitted to humans through bites of infected sand flies. Neuroinvasive TOSV infections are leading causes meningitis/encephalitis in southern Europe and notifiable Italy since 2016. In 2022–23, experienced extreme climate anomalies a concomitant increase mosquito tick-borne disease transmission. Aim To identify the spatiotemporal distribution risk groups neuroinvasive 2022–23 vs 2016–21. Methods We retrospectively described all autochthonous,...
Ecotoxicological risk and the mode of action human drugs on non-target marine animals remain unclear, keeping a gap knowledge risks related to ecosystem disruption chemical contamination food chains. Understanding these impacts is critical developing proper waste management practices regulatory frameworks prevent long-term environmental health problems. This study investigates Gemfibrozil, Metformin, Ramipril, Venlafaxine, individually combined Mytilus galloprovincialis over 30 days assesses...
ABSTRACT Introduction Pancreatic cancer arising in the context of BRCA predisposition may benefit from poly(ADP‐ribose) polymerase inhibitors. We analyzed real‐world data on impact olaparib survival metastatic pancreatic patients harboring germline mutations Italy, where is not reimbursed for this indication. Methods Clinico/pathological with documented 1‐2 pathogenic variants who had received first‐line chemotherapy disease were collected 23 Italian oncology departments and exposure overall...
Background To investigate the impact of pre-treatment lactate dehydrogenase (LDH) levels on outcome patients with metastatic colorectal cancer treated first-line chemotherapy or without anti-VEGF monoclonal antibody, bevacizumab, in a phase III prospective multicentre randomized ITACa (Italian Trial Advanced Colorectal Cancer) trial. Methods Three hundred and seventy enrolled onto trial were considered for this study, 176 receiving (either FOLFIRI FOLFOX) plus bevacizumab 194 only....
Abstract Background The drosophilid Phortica variegata is known as vector of Thelazia callipaeda , the oriental eyeworm native to Asia that has become an emergent zoonotic agent in several European regions. Unlike almost all other arthropod vectors pathogens, only P. males feed lachrymal secretions animals, ingesting first-stage larvae (L1) worm living orbital cavities host, and allowing with same behaviour introduction infective L3. Despite increased detection T. many countries, information...
Abstract Shellfish are increasingly been looked at as sustainable food sources that provide additional ecosystem services. However, their role CO2 sinks or is still debated. To quantify it, shell accretion dynamics should be accounted for. the component usually calculated with allometric scaling, in most bivalve models. With this study, was added to a bioenergetic model of Manilla clam (Ruditapes philippinarum), and parameter linking assimilated energy towards growth (KSH) calibrated for...
Aim: The aim of this study was to investigate the role a new inflammatory index (Colon Inflammatory Index [CII]) as predictor prognosis and treatment efficacy in patients with metastatic colorectal cancer (mCRC) enrolled prospective multicenter randomized ITACa (Italian Trial Advanced Colorectal Cancer) trial receive first-line chemotherapy (CT)+ bevacizumab or CT alone. Patients methods: Between November 14, 2007 March 6, 2012, 276 diagnosed CRC were available for baseline...
•Nab-paclitaxel plus gemcitabine dose intensity and toxicity were as expected from the literature.•Toxicity with platinum-based triplets was unmodified to price of consistently reduced intensity.•Dose for quadruplets preserved greater hematological diarrhea.•RECIST CA19.9 responses higher in metastatic patients.•Longer progression-free overall survival observed three- four-drug regimens stage IV (AJCC/UICC TNM 8th Edition, 2017) patients. BackgroundGermline BRCA1-2 pathogenic variants...
The sharp decrease in the cost of RNA-sequencing and rapid improvement computational analysis eco-toxicogenomic data have brought new insights into adverse effects chemicals on aquatic organisms. Yet, transcriptomics is generally applied qualitatively environmental risk assessments, hampering more effective exploitation this evidence through multidisciplinary studies. In view limitation, a methodology here presented to quantitatively elaborate transcriptional support assessment. proposed...
Abstract Background Oncologists are often concerned that talking about death with patients may hinder their relationship. However, the views of held by have not been thoroughly investigated. This study aimed to describe perception among advanced cancer receiving early palliative care (EPC) and caregivers. Material Methods Qualitative quantitative analyses were performed on 2 databases: (a) transcripts open-ended questionnaires administered 130 EPC a mean age 68.4 years 115 primary caregivers...
Aquaculture productivity in coastal lagoons is endangered by a complex interplay of anthropogenic and environmental factors, amplified the effects climate change these sensitive areas. To reach more comprehensive assessment farming sites quality, quantitative Weight Evidence approach (QWoE) applied for first time to data collected at four Manila clam (R. philippinarum) Venice lagoon (Italy). This included sediment chemical bioaccumulation, biological responses. Results revealed greater...