A5100628227- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Respiratory viral infections research
- CAR-T cell therapy research
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Galectins and Cancer Biology
- Sepsis Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- Plant Virus Research Studies
- Macrophage Migration Inhibitory Factor
- Abdominal vascular conditions and treatments
- Neonatal and fetal brain pathology
- RNA and protein synthesis mechanisms
- Neurological Disease Mechanisms and Treatments
- Research in Cotton Cultivation
- Amoebic Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatitis C virus research
- Immune cells in cancer
Zhongkai University of Agriculture and Engineering
2024
Zhejiang University
2011-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Sir Run Run Shaw Hospital
2019-2023
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2011-2021
Zhejiang Academy of Medical Sciences
2018
First Affiliated Hospital Zhejiang University
2017
Peking Union Medical College Hospital
2014
Chinese Academy of Medical Sciences & Peking Union Medical College
2014
Abstract Background Although gut microbiota dysbiosis has been reported in HIV infected individuals recently, the relationship between and immune activation patients with different responses to highly active antiretroviral therapy (HAART) is still not well understood. Gut were studied 36 non-HIV-infected subjects (healthy controls) 58 HIV-infected individuals, including 28 immunological responders (IR) 30 non-responders (INR) (≥500 < 200 CD4+ T-cell counts/μl after 2 years of HIV-1 viral...
The widespread threat of severe acute respiratory syndrome (SARS) to human life has spawned challenges develop fast and accurate analytical methods for its early diagnosis create a safe antiviral vaccine preventive use. Consequently, we thoroughly investigated the immunoreactivities with patient sera series synthesized peptides from SARS-coronavirus structural proteins.We 41 ranging in size 16 25 amino acid residues relatively high hydrophilicity. SARS were determined by ELISA.Four epitopic...
Plant disease resistance genes are a key component of defending plants from range pathogens. The majority these belong to the super-family that harbors Nucleotide-binding site (NBS). A number studies have focused on NBS-encoding in resistant breeding programs for diverse plants. However, little information has been reported with an emphasis systematic analysis and comparison cotton. To fill this gap knowledge, study, we identified investigated cotton using whole genome sequence Gossypium...
Abstract Herpes zoster (HZ) is an infectious dermatosis with high incidence worldwide. Age a key risk factor for HZ, and postherpetic neuralgia (PHN) the main sequelae. Until now, no index has been available to predict pathogenesis of PHN, rare reports have focused on immune response during aging PHN. In this study, we selected immunoglobulin complement proteins as markers humoral immunity, while T lymphocyte subsets natural killer (NK) cells were cell systematically study characteristics...
We aim to investigate the effects of Tim-3 and programmed cell death-1 (PD-1) on monocytes T lymphocytes in septic patients. Expression PD-1 CD3, CD4, CD8 was determined using flow cytometry. CBA technique utilized determine expression cytokines lymphocyte supernatant addition IL-10 TNF-α positivity presence and/or receptor blockade. Compared with normal control, significant elevation observed CD3 (P = 0.004), monocytes. Blockade signaling pathway contributed patients, while blockade only...
The disease neonatal sepsis (NS) poses a serious threat to life, and its pathogenesis remains unclear. Using the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) were identified functional enrichment analyses conducted. Three machine learning algorithms containing least absolute shrinkage selection operator (LASSO), support vector recursive feature elimination (SVM-RFE), random forest (RF) applied identify optimal (OFGs). This study conducted CIBERSORT present...
Abstract Background T cell receptor (TCR) reflects the status and function of cells. We previously developed a gene melting spectral pattern (GMSP) assay, which rapidly detects clonal expansion β variable (TCRBV) in patients with HBV by using quantitative real-time reverse transcription PCR (qRT-PCR) DNA curve analysis. However, molecular profiles TCRBV peripheral blood mononuclear cells (PBMCs) CD8 + , - subsets from chronic severe hepatitis B (CSHB) have not been well described. Methods...
Objective: We aimed to analyse the alterations of subgroups in T cells during different phases post-ischaemic stroke (IS), explore possible mechanism stroke-induced immune depression (SIID). Methods: Sixty-four IS patients were divided into three groups: an acute phase group, a sub-acute and stable group. Fourteen healthy individuals selected as normal controls. The phenotype distribution peripheral blood was analysed. Programmed cell death-1 (PD-1) immunoglobulin mucin domain 3 (Tim-3)...
Abstract Background T cells are closely linked to the clinical manifestations of subjects with Mycobacterium tuberculosis (MTB) infection. cell receptor beta variable (TCRBV) is a signal and indicative molecule on membrane lymphocytes, reflecting composition specificity cells. The molecular profiles TCRBV in peripheral blood mononuclear (PBMCs) their subpopulations (CD4 + CD8 cells) from active (TB) or latent TB infection (LTBI) have not been well described. Methods In 42 LTBI, PMBCs subsets...
<title>Abstract</title> <bold>Background</bold>The extent to which sinks are contaminated by carbapenem-resistant<italic>Acinetobacter baumannii</italic>(CRAB) in intensive care units (ICUs) and the association between these hospital acquired CRAB infections during non-cluster period remains largely unknown .<bold>Methods</bold>A prospective multicenter study was performed 16 ICUs, including 9 general ICUs (GICUs) 7 neonatal (NICUs), at 11 tertiary hospitals Chengdu from March 2019 January...
<title>Abstract</title> Background: Human adenovirus (HAdV) is highly prevalent in children and associated with various diseases. Monitoring of the spread HAdV species crucial many aspects (e.g. genomic surveillance). Methods: A total 596 throat swabs were collected from pediatric patients diagnosed acute respiratory tract infection outpatient department July 2021 to January 2022. was detected using a real-time PCR method. hexon genes amplified by PCR, sequenced, then analyzed, compared...
<title>Abstract</title> Background: Human adenovirus (HAdV) is highly prevalent in children and associated with various diseases. Monitoring of the spread HAdV species crucial many aspects (e.g. genomic surveillance). Methods: A total 596 throat swabs were collected from pediatric patients diagnosed acute respiratory tract infection outpatient department July 2021 to January 2022. was detected using a real-time PCR method. hexon genes amplified by PCR, sequenced, then analyzed, compared...
Introduction The extent to which sinks are contaminated by carbapenem-resistant Acinetobacter baumannii (CRAB) in intensive care units (ICUs) and the association between these hospital-acquired CRAB infections during non-cluster period remains largely unknown. Here, we performed a prospective multicenter study 16 ICUs at 11 tertiary hospitals Chengdu, China. Methods We sampled sinks, collected clinical isolates, conducted whole-genome sequencing analysis. Results A total of 789 swabs were...